人参五味子汤加减联合调肺运脾小儿推拿法对儿童咳嗽肺脾气虚证的应用效果

摘要/Abstract

摘要： 目的探讨人参五味子汤加减联合调肺运脾小儿推拿法对儿童咳嗽肺脾气虚证的应用效果。方法选取2021年6月—2023年6月毕节市中医医院收治的80例肺脾气虚证咳嗽患儿作为研究对象,应用抽签法将所有患儿分为观察组与对照组,每组40例。对照组采取常规西医治疗,观察组患儿在常规西医治疗基础上增加人参五味子汤加减联合调肺运脾小儿推拿法治疗。对比两组患儿临床疗效,治疗前后中医证候积分及炎症因子水平变化,并对比两组患儿治疗过程中出现的不良反应情况。结果观察组治疗总有效率明显高于对照组（P<0.05）。治疗前两组患儿主症、次症中医证候积分对比,差异无统计学意义（P>0.05）;治疗后两组患儿主症、次症中医证候积分水平均降低,且观察组低于对照组（P<0.05）。治疗前两组患儿TNF-α、CRP、IL-6水平对比,差异无统计学意义（P>0.05）;治疗后两组患儿TNF-α、CRP、IL-6水平均降低,且观察组低于对照组（P<0.05）。两组患儿均无明显不良反应发生,且不良反应对比,差异无统计学意义（P>0.05）。结论人参五味子汤加减联合调肺运脾小儿推拿法可提升肺脾气虚证咳嗽患儿的临床疗效,减轻临床症状,降低机体炎症反应水平,安全性较高。

关键词: 人参五味子汤, 调肺运脾小儿推拿法, 慢性咳嗽, 脾气虚证, 临床疗效, 炎症因子

Abstract: Objective To explore the application effect of Ginseng Schisandra Chinensis Decoction plus lung and spleen regulating infantile massage on children with cough, lung and spleen deficiency syndrome. Methods A total of 80 cases of patients with lung temper deficiency and cough admitted from June 2021 to June 2023 were selected as research subjects, and all children were divided into observation group and control group by lottery method, with 40 cases in each group. Control group to take conventional western medicine treatment, observation group of children on the basis of conventional western medicine treatment increase of ginseng joint lung spleen massage treatment, compare two groups of children with clinical curative effect, before and after treatment of TCM syndrome integral and inflammation factor level change, and compare the two groups of children in the process of treatment of adverse reactions. Results The total response rate of the observation group was significantly higher than that of the control group (P<0.05); There was no significant difference in the comparison of the two groups before treatment (P>0.05), After treatment, the score level of TCM syndrome in both groups was decreased, And the observation group was lower than the control group (P <0.05); TNF-α, CRP and IL-6 between the two groups before treatment (P>0.05), After treatment, TNF-α, CRP-and IL-6, And the observation group was lower than the control group (P<0.05); Neither group had significant adverse effects, There was no significant difference in the comparison of adverse effects(P>0.05). Conclusion The addition and subtraction of Ginseng Schisandra Chinensis Decoction combined with lung and spleen regulating infantile massage can improve the clinical efficacy of children with cough of lung spleen deficiency syndrome, alleviate clinical symptoms, reduce the level of inflammatory reaction of the body, and has high safety.

Key words: Ginseng Schisandra Chinensis Decoction, regulating lung transport spleen massage method for children, chronic cough, Qi deficiency syndrome, clinical effect, inflammatory factor

中图分类号:

R272.6

舒秀锦, 许庆龄, 江宙蔚, 姬婷, 瓦杨, 徐婷, 赵维, 程耀, 李凤耀. 人参五味子汤加减联合调肺运脾小儿推拿法对儿童咳嗽肺脾气虚证的应用效果[J]. 中华养生保健, 2024, 42(15): 26-29.

SHU Xiu-jin, XU Qing-ling, JIANG Zhou-wei, JI Ting, WA Yang, XU Ting, ZHAO Wei, CHENG Yao, LI Feng-yao. Application Effect of Modified Ginseng Schisandra Decoction Combined with Infantile Massage Method of Regulating Lung and Activating Spleen on Children's Cough with Lung and Spleen Qi Deficiency Syndrome[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(15): 26-29.

参考文献

[1] 李亚珍,酆孟洁,李晨辉,等.2020年欧洲呼吸学会成人及儿童慢性咳嗽诊断与治疗指南亮点解读[J].国际呼吸杂志,2021,41(10):721-728.
[2] 张梦思,吴文华,李文.调肺运脾推拿法治疗肺炎支原体感染后慢性咳嗽(肺脾气虚证)的临床研究[J].上海中医药杂志,2021,55(9):64-67.
[3] 周立,陈琦琦,李慧.人参五味子汤对支气管哮喘患儿外周血白细胞介素-8、白细胞介素-17、瘦素水平和肺功能的影响[J].儿科药学杂志,2021,27(2):9-11.
[4] 刘颖. 中医定向透药联合调肺运脾推拿法治疗儿童大叶性肺炎的效果分析[J].医学理论与实践,2022,35(6):1014-1016.
[5] 中华医学会儿科学分会临床药理学组,国家儿童健康与疾病临床医学研究中心,中华医学会儿科学分会呼吸学组,等.中国儿童咳嗽诊断与治疗临床实践指南(2021版)[J].中华儿科杂志,2021,59(9):720-729.
[6] 朱金凤,洪玲玲,侯海慧,等.慢性咳嗽的中医诊治策略分析[J].中国中医基础医学杂志,2021,27(8):1301-1303,1324.
[7] 郑筱萸. 中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:2-8.
[8] 范钰晗,史利卿,马建岭,等.慢性咳嗽寒咳证中医病因病机及物质基础探讨[J].现代中医临床,2021,28(5):65-68.
[9] 刘智霖,史利卿,马建岭,等.难治性慢性咳嗽的”多维度病机”认识与证治浅探[J].北京中医药大学学报,2022,45(5):507-512.
[10] 张宁宁,吴力群.吴力群治疗小儿胸闷变异性哮喘经验[J].中医药导报,2020,26(4):113-114,118.
[11] 罗建峰,陈梅兰.调肺运脾小儿推拿法联合二陈汤加减治疗痰湿蕴肺型小儿慢性咳嗽临床研究[J].新中医,2022,54(14):176-179.
[12] 孙安兵,杨殿福,户晓艳.物理康复联合小青龙汤治疗儿童哮喘缓解期肺脾气虚证的效果[J].西安交通大学学报:医学版,2023,44(1):142-146.
[13] 李文,吴文华,姜之炎,等.调肺运脾小儿推拿法治疗痰湿蕴肺型儿童肺炎支原体感染后慢性咳嗽的疗效观察[J].中国中医基础医学杂志,2019,25(5):645-647,709.
[14] 吴宏华,郑建波,郑雪辉,等.清宁散加减治疗儿童咳嗽痰热郁肺证的疗效以及对血清IL-8和TNF-α水平的影响[J].中华中医药学刊,2022,40(6):210-212.
[15] 李予鄂,李明.吸入性糖皮质激素治疗小儿支气管哮喘的临床疗效及对血清炎性因子的影响[J].微循环学杂志,2023,33(1):48-51.
[16] 符秀宁,张华,吴慧莲.小儿热速清颗粒对急性上呼吸道感染症状缓解及血清炎性指标的影响[J].中华中医药学刊,2023,41(2):218-221.
[17] 何燕珊,王秋红.白术及其复方治疗糖尿病的药理研究及临床应用研究进展[J].广东药科大学学报,2020,36(1):155-158,封3.