CEA、CA125、CA153在肺癌诊断方面的临床应用价值

摘要/Abstract

摘要： 目的研究血清癌胚抗原（CEA）、糖类抗原125（CA125）、糖类抗原153（CA153）在肺癌诊断方面的临床应用价值。方法选择2018年3月—2023年3月在江阴市第五人民医院就诊的98例高度疑似肺腺癌的患者作为研究对象,所有患者于入院时测定血清CEA、CA125、CA153水平,以病理学检查结果作为金标准,分析CEA、CA125、CA153单独及联合检测对肺腺癌的诊断结果与金标准的一致性,计算CEA、CA125、CA153单独及联合检测对肺癌诊断的灵敏度、特异度、准确度、阳性预测值及阴性预测值,使用受试者工作曲线（ROC）分析其对肺腺癌的诊断效能。结果 98例高度疑似肺腺癌患者中,阳性患者80例,阴性患者18例。联合检测诊断肺腺癌与金标准的一致性较高,高于CEA、CA125、CA153单独检测。联合检测对肺腺癌诊断的灵敏度、准确度及阴性预测值均明显高于CEA、CA125、CA153单独检测,差异有统计学意义（P<0.05）;联合检测特异度、阳性预测值与CEA、CA125、CA153单独检测比较,差异无统计学意义（P>0.05）。ROC曲线显示,联合检测对肺腺癌具有较高的准确性,优于CEA、CA125、CA153单独检测。结论 CEA、CA125、CA153对肺腺癌均具有较好的诊断价值,联合使用能够有效提升诊断效能,应用价值较高。

关键词: CEA, CA125, CA153, 联合检测, 肺腺癌

Abstract: Objective To study the clinical value of serum carcinoembryonic antigen (CEA), carbohydrate antigen 125(CA125) and carbohydrate antigen 153(CA153) in the diagnosis of lung cancer. Methods From March 2018 to March 2023, 96 patients with highly suspected lung cancer in Jiangyin Fifth People's Hospital were taken as the research object. Serum CEA, CA125 and CA153 levels of all patients were measured at the time of admission,and the consistency between the diagnosis results of CEA, CA125 and CA153 for lung cancer and the gold standard was analyzed with pathological results as the gold standard. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CEA, CA125 and CA153 in the diagnosis of lung cancer were calculated, and the diagnostic efficacy of CEA,CA125 and CA153 in the diagnosis of lung cancer was analyzed by using the receiver's working curve (ROC). Results Among 98 highly suspected lung adenocarcinoma patients, 80 were positive and 18 were negative. The consistency between the combined detection of lung adenocarcinoma and the gold standard is higher than that of CEA, CA125, and CA153 alone. The sensitivity,accuracy and negative predictive value of combined detection in the diagnosis of lung cancer were significantly higher than those of CEA, CA125 and CA153 alone (P<0.05), while the specificity and positive predictive value were not significantly different from those of CEA, CA125 and CA153 alone (P>0.05). ROC curve shows that the combined detection has higher accuracy for lung cancer than CEA, CA125 and CA153 alone. Conclusion CEA, CA125 and CA153 have good diagnostic value for lung cancer, and their combined use can effectively improve the diagnostic efficiency and have high application value.

Key words: CEA, CA125, CA153, joint detection, lung cancer

中图分类号:

周梦姣. CEA、CA125、CA153在肺癌诊断方面的临床应用价值[J]. 中华养生保健, 2024, 42(15): 172-175.

ZHOU Meng-jiao. Clinical Application Value of CEA, CA125 and CA153 in Diagnosis of Lung Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(15): 172-175.

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