太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎的临床效果

摘要/Abstract

摘要： 目的探讨与分析太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎的临床效果。方法选取2022年9月—2023年6月在毕节市中医医院接受治疗的80例鼻窦炎患儿作为研究对象,根据1:1随机信封抽签法将80例患儿分为太子参组与对照组,各40例。两组患儿均接受鼻内镜手术治疗,对照组给予盐酸羟甲唑啉喷雾剂治疗,太子参组在对照组治疗的基础上给予太子参配方颗粒,均治疗观察4周,判定两组患儿的治疗效果。结果治疗4周后太子参组的总有效率高于对照组,差异有统计学意义（P<0.05）。治疗4周后太子参组与对照组的疼痛视觉模拟法（visual analog scale,VAS）量表评分都明显低于治疗前,且太子参组治疗4周后的疼痛VAS量表评分也低于对照组,差异有统计学意义（P<0.05）。治疗4周后太子参组与对照组的血清白细胞介素-2（interleukin-2,IL-2）、白细胞介素-6（interleukin-2,IL-6）含量明显均低于治疗前,且太子参组治疗4周后的IL-2、IL-6含量也明显低于对照组,差异有统计学意义（P<0.05）。太子参组治疗4周期间的鼻出血、鼻腔干燥、睡眠障碍、头晕等不良反应发生率低于对照组,差异有统计学意义（P<0.05）。结论太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎能缓解临床症状,提高患儿的总体治疗效果,能抑制IL-2、IL-6的表达,能降低不良反应发生率。

关键词: 太子参配方颗粒, 盐酸羟甲唑啉喷雾剂, 儿童, 鼻窦炎, 白细胞介素-2, 不良反应

Abstract: Objective To explore and analysis the clinical effects of Radix Pseudostellariae Formula Granules+Hydroxymetazoline Hydrochloride Spray in the treatment of children's Sinusitis. Methods A total of 80 cases of children with Sinusitis who were treated in n Bijie Traditional Chinese Medicine Hospital from September 2022 to June 2023 were selected as the study subjects. Accorded to the principle of 1:1 random envelope drawing, 80 children were divided into the Pseudostellaria group of 40 cases and the control group of 40 cases. Both groups of children were received endoscopic surgery. The control group were treated with hydroxymethylazoline hydrochloride spray, and the Pseudostellaria group were treated with Pseudostellaria formula granules on the basis of the control group. Both groups were observed for 4 weeks, and were to determine the treatment effects of the two groups of children. Results After 4 weeks of treatment, the total effective rates of the Pseudostellaria group were 97.50%, while the control group were 85.00%. The Pseudostellaria group were significantly higher than the control group (P<0.05). After 4 weeks of treatment, the pain VAS scores of the Pseudostellaria group and the control group were significantly lower than before treatment (P<0.05), and the pain VAS scores of the Pseudostellaria group after 4 weeks of treatment were also lower than the control group (P<0.05). After 4 weeks of treatment, the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group and the control group were significantly lower than those before treatment (P<0.05), and the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group after 4 weeks of treatment were also significantly lower than those in the control group (P<0.05). The incidence of adverse reactions such as epistaxis, nasal dryness, Sleep disorder and dizziness during the 4-week treatment period in the Pseudostellaria group were 5.00%, while that in the control group were 22.50%. The incidence of adverse reactions in the Pseudostellaria group were significantly lower than that in the control group (P<0.05). Conclusion Pseudostellaria formula granule+hydroxymethylazoline hydrochloride spray can alleviate clinical symptoms, improve the overall therapeutic effect of children with Sinusitis, inhibit the expression of serum Interleukin 2 and Interleukin 6, and reduce the incidence of adverse reactions.

Key words: pseudostellaria formula granule, hydroxymetazoline hydrochloride spray, children, sinusitis, interleukin 2, adverse reactions

中图分类号:

R272.6

舒秀锦, 张坤, 李凤耀, 程耀, 许庆龄, 江宙蔚. 太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎的临床效果[J]. 中华养生保健, 2024, 42(14): 8-11.

SHU Xiu-jin, ZHANg Kun, LI Feng-yao, CHENG Yao, XU Qing-ling, JIANG Zhou-wei. Clinical Effect of Pseudostellaria Formula Granules+Hydroxymetazoline Hydrochloride Spray in the Treatment of Children's Sinusitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(14): 8-11.

参考文献

[1] 赵慧娜,李玉杰,杨长君,等.鼻渊通窍颗粒联合头孢地尼对鼻窦炎合并鼻息肉患者鼻阻力及HMGB1、IFN-γ和IL-5水平的影响[J].广东医学,2023,44(5):612-616.
[2] 袁艳红,尉瑞,陈璐璐,等.鼻康复鼻腔填塞治疗急性鼻窦炎的临床研究[J].南京中医药大学学报,2023,39(4):312-318.
[3] 谭畅,张利丹,支英杰,等.鼻渊通窍颗粒治疗慢性鼻窦炎有效性和安全性的系统评价与Meta分析[J].中国中药杂志,2022,47(16):4489-4504.
[4] 姜雪莲,张静月,卫旭东.基于Meta分析桥接网络药理学的鼻渊通窍颗粒治疗慢性鼻窦炎的疗效评价及潜在机制研究[J].山东大学耳鼻喉眼学报,2022,36(3):226-236.
[5] 李治金,张玲,杨佳凤,等.通鼻消涕颗粒对慢性鼻窦炎鼻黏膜功能的影响[J].云南中医学院学报,2022,45(2):1-4.
[6] 李杉杉,周恩,李湘胜.基于网络药理学与分子对接探究鼻渊通窍颗粒治疗慢性鼻窦炎的作用机制[J].现代药物与临床,2022,37(7):1452-1463.
[7] 崔栋,卢炎.经典名方与中成药治疗慢性鼻窦炎的临床应用研究进展[J].药物评价研究,2022,45(6):1206-1212.
[8] 高颖,王瑞,温树信,等.鼻炎宁颗粒对慢性鼻窦炎局部症状的缓解和免疫功能的影响[J].中国中药杂志,2022,47(17):4789-4798.
[9] 王成硕,张罗.嗜酸粒细胞型慢性鼻窦炎的诊断标准[J].中华耳鼻咽喉头颈外科杂志,2022,57(10):1173-1177.
[10] 国家中药管理局.中医病症诊断疗效标准[S].南京:南京大学出版社,1994:124.
[11] 林尚泽,龚正鹏,王贵发,等.对慢性鼻窦炎鼻息肉临床分型分期及内窥镜鼻窦手术疗效评定标准的建议[J].贵州医药,2002,26(2):190-192.
[12] 吴紫陆,李静波,蔡纪堂,等.鼻康复鼻腔透药治疗儿童慢性鼻窦炎疗效观察[J].南京中医药大学学报,2021,37(5):662-668.
[13] 江成琼,仇弋戈,郭忠琴.鼻渊通窍颗粒联合阿奇霉素肠溶片治疗肺炎支原体感染性慢性鼻-鼻窦炎临床研究[J].中国药业,2021,30(5):79-81.
[14] 吴琪,刘干.盐酸羟甲唑啉喷雾剂对双侧上颌窦炎的疗效[J].医学研究杂志,2020,49(1):158-162.
[15] 朱继平,朱潇月,鲍靖,等.欧龙马滴剂联合羟甲唑啉治疗慢性鼻窦炎急性发作的临床研究[J].现代药物与临床,2019,34(7):2019-2022.
[16] 孙建设,李晓华,王凯,等.香菊片联合盐酸羟甲唑啉喷雾剂治疗慢性鼻窦炎的临床研究[J].现代药物与临床,2019,34(5):1422-1425.
[17] 赵晨,赵娇,赵晓波,等.复方太子参止咳益气散治疗大鼠哮喘的机制探讨[J].中国实验动物学报,2019,27(4):532-539.
[18] 李俊娟,熊向菁,王青海,等.PAR-2、COX-2在嗜酸性慢性鼻-鼻窦炎鼻息肉患者组织中的表达及其临床意义[J].现代医学,2022,50(3):336-342.
[19] 杨娜,柳荫.香菊胶囊联合盐酸羟甲唑啉喷雾剂治疗小儿过敏性鼻炎的临床研究[J].中国煤炭工业医学杂志,2019,22(5):528-531.
[20] 高淑青,刘佳,王冬梅,等.丙酸氟替卡松鼻喷雾剂联合鼻腔冲洗或内镜下鼻窦手术治疗儿童变应性鼻炎致慢性鼻窦炎的疗效观察[J].药物评价研究,2023,46(3):641-647.