直肠滴入中药对CoxA16、EV71肠道病毒感染手足口病的疗效

摘要/Abstract

摘要： 目的观察直肠滴入中药对CoxA16、EV71肠道病毒感染手足口病的疗效。方法选取2019年8月—2022年8月贵州水矿控股集团有限公司总医院CoxA16、EV71肠道病毒感染手足口病患儿85例,按照随机数表法分为观察组（42例）和对照组（43例）,其中对照组患儿给予利巴韦林治疗,观察组患儿给予直肠滴入中药治疗。对比两组患儿治疗前后口腔疱疹、发热、皮疹等症状的评分,治疗前后患儿炎症因子、免疫指标水平及两组患儿治疗后不良反应发生率。结果治疗前,两组患儿的口腔疱疹、发热、皮疹评分差异无统计学意义（P>0.05）,治疗后,两组患儿的口腔疱疹、发热、皮疹评分均降低,并且治疗后观察组患儿的以上症状评分低于对照组（P<0.05）;治疗后,两组患儿白细胞介素（IL）-6、IL-8、肿瘤坏死因子（TNF）-α均降低,并且治疗后观察组患儿的以上降低幅度大于对照组（P<0.05）;治疗后,两组患儿CD4⁺、CD3⁺、CD4⁺/CD8⁺水平均升高,CD8⁺水平降低,并且治疗后观察组患儿的变化幅度大于对照组（P<0.05）;观察组患儿不良反应发生率为4.76%,对照组患儿不良反应发生率为18.60%,观察组不良反应发生率低于对照组（P<0.05）。结论给予CoxA16、EV71肠道病毒感染手足口病患儿直肠滴入中药治疗,能减轻患儿临床症状及炎性反应,改善免疫功能,且不良反应少,值得借鉴。

关键词: 直肠滴入中药, CoxA16、EV71肠道病毒感染手足口病, 免疫水平

Abstract: Objective To observe the effect of rectal drip of traditional Chinese medicine on CoxA16 and EV71 enterovirus infection of hand-foot-mouth disease. Methods Selected 85 children with CoxA16, EV71 enterovirus infection in HFMD, Guizhou, General Hospital from August 2019 to August 2022, and divided into observation group (42 cases) and control group (43 cases) according to the method of digital table at any time. The patients in the control group were treated with ribavirin, and the patients in the observation group were treated with rectal drip of traditional Chinese medicine. The scores of oral herpes, fever, rash and other symptoms of the two groups before and after treatment were compared, as well as the inflammatory factors of patients before and after treatment. The level of immune indicators and the incidence of adverse reactions after treatment were compared in both groups and between the two groups. Results There was no statistically significant difference in the scores of oral herpes, fever and rash between the two groups before treatment (P>0.05); IL-6, IL-8, TNF in the two groups before treatment- α The level difference was not statistically significant (P>0.05). After treatment, IL-6, IL-8, TNF in the two groups- α Both of them were decreased, and the above reduction of patients in the observation group was greater than that in the control group after treatment(P<0.05); After treatment, the levels of CD4⁺, CD3⁺ and CD4⁺ / CD8⁺ increased in both groups, and the level of CD8+ decreased, and the change of children in the observation group was greater than that in the control group (P<0.05); The incidence of adverse reactions in the observation group was 4.76%, and that in the control group was 18.60%. The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05). Conclusion The treatment of rectal drip of traditional Chinese medicine in children with CoxA16 and EV71 enterovirus infection of hand-foot-mouth disease can reduce the clinical symptoms and inflammatory reactions of children, improve the immune function, and have fewer adverse reactions, which is worthy of reference.

Key words: rectal drip of traditional Chinese medicine, CoxA16 and EV71 enteroviruses infect, HFMD, immune level

中图分类号:

R254

毛梅, 陈波. 直肠滴入中药对CoxA16、EV71肠道病毒感染手足口病的疗效[J]. 中华养生保健, 2024, 42(14): 170-174.

MAO Mei, CHEN Bo. Effect of Rectal Drip of Traditional Chinese Medicine on CoxA16 and EV71 Enterovirus Infection of Hand, Foot and Mouth Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(14): 170-174.

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