多索茶碱在慢性支气管炎急性发作的应用对血嗜酸粒细胞数量的影响

摘要/Abstract

摘要： 目的探讨与分析多索茶碱在慢性支气管炎急性发作的应用对血嗜酸粒细胞数量的影响。方法选取2017年1月—2022年12月在苏州市吴江区第五人民医院诊治的慢性支气管炎急性发作患者82例作为研究对象,根据随机数表法将所有患者分为研究组与对照组,每组41例。研究组与对照组都给予常规的祛痰、抗感染等治疗,对照组给予复方异丙托溴铵治疗,研究组在对照组治疗的基础上给予多索茶碱治疗。在治疗7 d后,比较两组的总有效率、两组患者呼吸困难、咳嗽咳痰、肺部啰音等消失时间、在治疗前、治疗7 d后第1秒用力呼气量占用力肺活量的百分比（FEV₁/FVC）、FEV₁、外周血嗜酸粒细胞含量。结果治疗7 d后,研究组的总有效率高于对照组,差异有统计学意义（P<0.05）。研究组的呼吸困难、咳嗽咳痰、肺部啰音症状消失时间与对照组相比明显缩短,差异有统计学意义（P<0.05）。研究组与对照组治疗7 d后的FEV₁/ FVC、FEV₁都明显高于治疗前,且研究组治疗7 d后的FEV₁/FVC、FEV₁与对照组相比明显提高,差异有统计学意义（P<0.05）。研究组与对照组治疗7 d后的外周血嗜酸粒细胞含量均明显低于治疗前,且研究组治疗7 d后的外周血嗜酸粒细胞含量与对照组相比明显降低,差异有统计学意义（P<0.05）。结论多索茶碱在慢性支气管炎急性发作的应用能改善患者的临床症状,提高治疗效果,改善患者的肺功能,降低患者的外周血嗜酸粒细胞含量。

关键词: 多索茶碱, 慢性支气管炎, 急性发作, 肺功能, 外周血, 嗜酸粒细胞, 复方异丙托溴铵

Abstract: Objective To explore and analyze the effect of doxofylline on the number of eosinophils in blood during acute exacerbation of chronic bronchitis. Methods From January 2017 to December 2022,82 patients with acute attack of chronic bronchitis treated in the Fifth People's Hospital of Wujiang District, Suzhou were selected as the study subjects. According to a 1:1 random number table method, the patients were divided into the observation group of 41 cases and the control group of 41 cases. Both groups were treated with expectorant, anti infection. The control group were treated with compound Ipratropium bromide, while the observation group were treated with doxofylline on top of the control group. Both the doxophylline group and the control group were treated for 7 d to detect the total response rate of patients after 7 d of treatment, the duration of disappearance time of dyspnea, cough, sputum, lung rales, the count of FEV₁/ FVC, the level of FEV₁ and peripheral blood acidophilia granulocytic content were compared before and 7 d after treatment in each group and between the groups. Results After 7 days of treatment, the total effective rate of the study group was higher than that of the control group, The difference is statistically significant (P<0.05). The duration of disappearance of symptoms such as dyspnea, cough and phlegm, and lung rales in the observation group were significantly reduced compared to the control group (P<0.05). The percentage of forced expiratory volume (FEV) in the first second to forced vital capacity( FEV₁/ FVC) and FEV1 in both groups after 7 days of treatment were significantly higher than those before treatment (P<0.05). The FEV₁/ FVC and forced expiratory volume in the first second in the observation group after 7 days of treatment were significantly higher than those in the control group (P<0.05). The content of eosinophils in the peripheral blood of both groups after 7 days of treatment were significantly lower than before treatment (P<0.05), while the content of eosinophils in the peripheral blood of the observation group after 7 days of treatment were significantly lower than that of the control group (P<0.05). Conclusion The application of doxofylline in acute exacerbation of chronic bronchitis can promote the improvement of clinical symptoms, improve treatment effectiveness, improve lung function, and reduce the content of eosinophils in the patient's peripheral blood.

Key words: doxophylline, chronic bronchitis, acute attack, lung function, peripheral blood, eosinophils, compound Ipratropium bromide

中图分类号:

R562.2

钱文飞, 曹祖义. 多索茶碱在慢性支气管炎急性发作的应用对血嗜酸粒细胞数量的影响[J]. 中华养生保健, 2024, 42(13): 180-183.

QIAN Wen-fei, CAO Zu-yi. The Effect of Doxofylline on the Number of Eosinophils in Blood During Acute Exacerbation of Chronic Bronchitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(13): 180-183.

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