环硅酸锆钠散联合传统降钾方案用于慢性肾衰竭患者的临床效果研究

摘要/Abstract

摘要： 目的探究和分析环硅酸锆钠散联合传统降钾方案用于慢性肾衰竭患者的高钾血症降钾治疗临床效果。方法选择2021年1月—2023年8月黔西市人民医院收治的70例慢性肾衰竭合并高钾血症患者作为研究对象,采用随机数表法将其分为对照组和观察组,每组35例,对照组采用传统降钾方案治疗,观察组采用环硅酸锆钠散联合传统降钾方案治疗。比较两组患者治疗前、治疗24 h、48 h时的血钾水平、血清肌酐、尿素氮等肾功能指标水平、治疗期间的不良反应发生率及治疗总有效率。结果治疗前,两组血钾水平比较,差异无统计学意义（P>0.05）;治疗24 h、48 h时,观察组血钾水平均低于对照组,差异有统计学意义（P<0.05）。治疗前,两组血清肌酐、尿素氮等肾功能指标水平比较,差异无统计学意义（P>0.05）,治疗24 h、48 h时,观察组血清肌酐、尿素氮等肾功能指标水平均低于对照组,差异有统计学意义（P<0.05）。观察组治疗期间的不良反应发生率低于对照组,差异有统计学意义（P<0.05）。观察组治疗总有效率高于对照组,差异有统计学意义（P<0.05）。结论环硅酸锆钠散联合传统降钾方案用于慢性肾衰竭患者的高钾血症降钾治疗临床效果显著,不仅能有效降低患者机体血钾和肾功能指标水平,还能改善其机体不适症状,且安全性较高,值得临床应用。

关键词: 环硅酸锆钠散, 慢性肾衰竭, 高钾血症, 降钾, 效果

Abstract: Objective To explore and analyze the clinical efficacy of sodium zirconate cyclosilicate powder combined with traditional potassium lowering therapy in the treatment of hyperkalemia in patients with chronic renal failure. Methods 70 patients of chronic renal failure with hyperkalemia admitted to Qianxi People's Hospital from January 2021 to August 2023 were selected as the study subjects, and divided into control group and observation group by random number table method, with 35 cases in each group.The control group was treated with traditional potassium lowering regimen, while the observation group was treated with sodium zirconium silicate powder combined with traditional potassium lowering regimen. The two groups of patients were compared before treatment and after 24 hours of treatment The blood potassium level, serum creatinine, urea nitrogen and other renal function indicators at 48 hours, the incidence of adverse reactions during treatment, and the total effective rate of treatment. Results There was no statistically significant difference in blood potassium levels between the two groups before treatment(P>0.05). At 24 and 48 hours of treatment, the observation group was lower than the control group(P<0.05); There was no statistically significant difference in the levels of serum creatinine, urea nitrogen and other renal function indicators between the two groups before treatment(P>0.05). At 24 and 48 hours of treatment, the observation group was lower than the control group(P<0.05);The incidence of adverse reactions during treatment was lower in the observation group than in the control group(P<0.05);The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). Conclusion The combination of sodium zirconate cyclosilicate powder and traditional potassium lowering therapy has a significant clinical effect on the treatment of hyperkalemia in patients with chronic renal failure. It can not only effectively reduce the levels of blood potassium and renal function in the patient's body, but also improve their discomfort symptoms, with high safety, and is worthy of clinical application and promotion.

Key words: sodium zirconium cyclosilicate, chronic renal failure, hyperkalemia, potassium reduction, effect

中图分类号:

R692

邱念. 环硅酸锆钠散联合传统降钾方案用于慢性肾衰竭患者的临床效果研究[J]. 中华养生保健, 2024, 42(13): 168-171.

QIU Nian. Sodium Zirconium Silicate Combined with Conventional Potassium Reduction Regimen for Chronic Renal Failure Clinical Effect Study of the Patients[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(13): 168-171.

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