帕金森病黑质高回声与临床特征的关系

摘要/Abstract

摘要： 目的探讨帕金森病（PD）患者经颅超声（TCS）下的黑质高回声面积与其临床特征的关系。方法收集2020年12月—2022年12月烟台业达医院诊断为PD的100例患者的基本资料,统一帕金森病评分量表（UPDRS）第Ⅲ部分（UPDRS-Ⅲ）得分,血尿酸水平及黑质高回声面积等资料,采用单因素和相关性分析比较黑质高回声面积与上述资料的相关性,并采用多元逐步线性回归分析的方法,分析黑质高回声面积与临床特征的关系。结果共纳入符合条件的78例PD患者,男性52例,女性26例,黑质高回声面积（0.67±0.52）cm²。通过单因素分析,发现患者性别、睡眠障碍、嗅觉减退、便秘等临床症状与黑质高回声面积之间无相关性;通过Spearman相关性分析,发现平均UPDRS-Ⅲ评分、尿酸水平及震颤与黑质高回声面积呈正相关（P<0.05）,而患者年龄、病程、强直等症状与黑质高回声面积无相关性（P>0.05）。最后采用多元逐步线性回归分析显示,平均UPDRS-Ⅲ评分、尿酸水平是PD患者的黑质高回声面积的独立预测因素。结论平均UPDRS-Ⅲ评分、尿酸水平可能是PD患者的黑质高回声面积的影响因素。

中图分类号:

高迪, 胡婠婧, 刘青霞, 栾海辉. 帕金森病黑质高回声与临床特征的关系[J]. 中华养生保健, 2024, 42(11): 53-57.

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