绝经后女性骨质疏松性脊柱骨折术后愈合与血清碱性磷酸酶表达的关系

摘要/Abstract

摘要： 目的探讨与分析绝经后女性骨质疏松性脊柱骨折术后愈合与血清碱性磷酸酶表达的关系。方法选择2018年1月—2022年1月西安市鄠邑区中医医院收治的76例绝经后女性骨质疏松性脊柱骨折患者作为研究对象,检测所有患者的血清碱性磷酸酶表达水平,随访患者的骨折术后愈合时间并进行相关性分析。结果所有患者都完成球囊扩张椎体后凸成形术治疗,围手术期未发生严重并发症。随访到2023年5月1日,76例患者骨折术后愈合时间45~114 d,平均（67.28±1.38）d,骨折延迟愈合16例,占比21.05%（延迟愈合组）。延迟愈合组的性别、身体质量指数、骨折主要部位、骨折到手术时间与正常愈合组比较,差异无统计学意义（P>0.05）。两组的骨密度、年龄、糖尿病占比等比较,差异有统计学意义（P<0.05）。两组的手术时间、术中出血量比较,差异无统计学意义（P>0.05）。延迟愈合组术后下床活动时间、术后住院时间与正常愈合组比较,差异有统计学意义（P<0.05）。延迟愈合组的血清碱性磷酸酶含量明显高于正常愈合组,差异有统计学意义（P<0.05）。在76例患者中,Pearson分析显示,血清碱性磷酸酶含量、糖尿病、术后住院时间、骨密度、年龄与骨折术后愈合时间存在相关性（P<0.05）。多元logistic回归分析显示,血清碱性磷酸酶含量、糖尿病、术后住院时间、骨密度、年龄等都为影响绝经后女性骨质疏松性脊柱骨折术后愈合时间的重要因素（P<0.05）。结论绝经后女性骨质疏松性脊柱骨折术后愈合的发生率比较高,与患者的血清碱性磷酸酶含量、糖尿病、年龄、骨密度、术后恢复情况存在相关性,血清碱性磷酸酶含量为影响骨折术后愈合时间的重要因素。

关键词: 绝经后女性, 骨质疏松, 脊柱骨折, 碱性磷酸酶, 骨折术后愈合时间

Abstract: Objective To explore and analysis the relationship between serum alkaline phosphatase expression and postoperative healing of osteoporotic spinal fractures in postmenopausal women. Methods The study period were from January 2018 to January 2022, and 76 cases of postmenopausal female patients with osteoporotic spinal fractures who were treated at a certain hospital were selected as the research subjects. The serum alkaline phosphatase expression levels of all patients were detected, and the fracture healing time of the patients were followed up for correlation analysis. Results All patients were completed balloon dilation and kyphoplasty of vertebral body,and there were no serious complications during the perioperative period. Followed up until May 1, 2023,the average fracture healing time of 76 patients were (67.28±1.38) days, with a minimum of 45 days and a maximum of 114 days. There were 16 cases of delayed fracture healing that accounted for 21.05%(delayed healing group). There were no significant difference in gender, body mass index, main site of fracture, and time from fracture to surgery compared between the delayed healing group and the normal healing group (P>0.05), but there were significant difference in bone density, age, diabetes compared between the two groups (P<0.05). There were no significant difference in surgical time and intraoperative bleeding compared between the two groups (P>0.05), while there were significant difference in diabetes and hospitalization time compared between the delayed healing group and the normal healing group (P<0.05). The serum alkaline phosphatase content in the delayed healing group were significantly higher than that in the normal healing group (P<0.05). In the 76 patients, Pearson analysis showed there were correlation between serum alkaline phosphatase content, diabetes, postoperative hospital stay, bone density, age, and fracture healing time (P<0.05). Multiple logistic regression analysis showed that serum alkaline phosphatase content, diabetes, postoperative hospitalization time, bone density,age,and other important factors affected the healing time of postmenopausal women with osteoporotic spinal fractures(P<0.05). Conclusion The incidence of osteoporotic spinal fracture healing in postmenopausal women is relatively high, which is correlated with the patient's serum alkaline phosphatase content,age, bone density,diabetes and postoperative recovery. Serum alkaline phosphatase content is an important factor affecting fracture healing time.

Key words: postmenopausal women, osteoporosis, spinal fractures, alkaline phosphatase, correlation, fracture healing time, delayed healing

中图分类号:

R683

张溪. 绝经后女性骨质疏松性脊柱骨折术后愈合与血清碱性磷酸酶表达的关系[J]. 中华养生保健, 2024, 42(11): 50-53.

ZHANG Xi. The Relationship between Serum Alkaline Phosphatase Expression and Postoperative Healing of Osteoporotic Spinal Fractures in Postmenopausal Women[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(11): 50-53.

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