化瘀清散汤内外结合对非增殖期糖尿病视网膜病变的应用

摘要/Abstract

摘要： 目的探讨化瘀清散汤内外结合疗法对非增殖期2型糖尿病视网膜病变的应用效果。方法选取2023年1月—2023年7月佛山市中医院三水医院收治的80例非增殖期2型糖尿病视网膜病变患者作为研究对象,应用抽签法将所有患者分为观察组与对照组,每组40例。对照组采取单纯基础性治疗,观察组在对照组基础上采取化瘀清散汤内外结合疗法治疗,对比两组患者治疗前后中医证候积分变化,眼底检查相关指标变化以及视网膜中央动脉血流参数变化。结果治疗后观察组中医证候积分低于对照组,差异有统计学意义（P<0.05）;治疗后,观察组视网膜毛细血管无灌注区（CNP）面积、视网膜平均循环时间（MCT）、视网膜血管渗漏（VT）面积、黄斑中心凹视网膜厚度（CMT）低于对照组,差异有统计学意义（P<0.05）;治疗后观察组患者阻力指数（RI）低于对照组,舒张末期血流速度（EDV）和收缩期峰值（PSV）高于对照组,差异有统计学意义（P<0.05）。结论化瘀清散汤内外结合疗法对非增殖期2型糖尿病视网膜病变的应用效果显著,可改善患者临床症状,改善眼底病变程度与视网膜血流动力学。

关键词: 化瘀清散汤, 内外结合疗法, 非增殖期2型糖尿病视网膜病变, 临床疗效

Abstract: Objective To explore the effect of Huayu Qingsan Decoction in combination with internal and external therapy on non proliferative type 2 Diabetic retinopathy. Methods A total of 80 patients with nonproliferative type 2 Diabetic retinopathy admitted to our hospital from January 2023 to July 2023 were selected as the study subjects. All patients were divided into an observation group and a control group by lot drawing, with 40 cases in each group. The control group was treated with simple basic Sex therapy, and the observation group was treated with Huayu Qingsan Decoction combined with internal and external treatment on the basis of the control group. The changes of TCM syndrome integral, fundus examination related indicators and central retinal artery blood flow parameters before and after treatment were compared between the two groups. Results There was no significant differencein the scores of traditional Chinese medicine syndromes related to visual acuity, thirst, irritability, sleep, appetite, defecation, urination, tongue condition, and pulse condition between the two groups of patients before treatment (P>0.05) . After treatment, the scores of traditional Chinese medicine syndromes related to visual acuity, thirst, irritability, sleep, appetite, defecation, urination, tongue condition, and pulse condition decreased in both groups of patients, with the observation group being lower than the control group (P<0.05). There was no significant difference in retinal CNP area, retinal MCT, retinal VT area, number of microvascular tumors, and CMT between the two groups before treatment (P>0.05). After treatment, the retinal CNP area, retinal MCT, retinal VT area, number of microvascular tumors, and CMT of the two groups of patients decreased, and the observation group was lower than the control group (P<0.05). There was no significant difference in the blood flow parameters of the central retinal artery between the two groups of patients before treatment (P>0.05). After treatment, the RI of the two groups of patients decreased, and the observation group was lower than the control group, while the EDV and PSV increased. The observation group was higher than the control group (P<0.05). Conclusion Huayu Qingsan Decoction is effective in the treatment of non proliferative type 2 Diabetic retinopathy, which can improve the clinical symptoms, the degree of fundus disease and retinal hemodynamics.

Key words: Huayu Qingsan Decoction, internal and external combination therapy, non proliferative type 2 diabetic retinopathy, clinical efficacy

中图分类号:

R276.7

李小艳, 陈婉芬, 欧少嫦. 化瘀清散汤内外结合对非增殖期糖尿病视网膜病变的应用[J]. 中华养生保健, 2024, 42(11): 16-19.

LI Xiao-yan, CHEN Wan-fen, OU Shao-chang. Effect of Huayu Qingsan Decoction Combined Internal and External Therapy on Non proliferative Type 2 Diabetic retinopathy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(11): 16-19.

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