芩连愈疡汤联合NSAIDs对十二指肠溃疡的治疗效果分析

摘要/Abstract

摘要： 目的探讨芩连愈疡汤联合非甾体类抗炎药物（NSAIDs）对十二指肠溃疡的治疗效果及对胃蛋白酶Ⅰ（PGⅠ）、人β₂防御素2（HBD-2）的影响。方法选取2020年8月—2023年5月甘肃省白银市中心医院收治的80例十二指肠溃疡患者作为研究对象,应用随机数表法将其分为观察组与对照组,每组40例。对照组采取常规四联疗法进行治疗,并应用布洛芬进行镇痛治疗,观察组在对照组基础上增加芩连愈疡汤治疗。比较两组患者临床疗效、治疗前后中医证候积分变化,并比较PGⅠ、HBD-2表达水平。结果观察组治疗总有效率明显高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者腕腹疼痛或痞满、恶心、纳呆、小便短黄、口干不欲饮、口苦相关中医证候积分比较,差异无统计学意义（P>0.05）;治疗后;两组患者腕腹疼痛或痞满、恶心、纳呆、小便短黄、口干不欲饮、口苦相关中医证候积分均降低,且观察组低于对照组,差异具有统计学意义（P<0.05）。治疗前,两组患者PGⅠ、HBD-2水平比较,差异无统计学意义（P>0.05）;治疗后,两组患者PGⅠ、HBD-2水平均降低,且观察组低于对照组,差异有统计学意义（P<0.05）。结论芩连愈疡汤联合NSAIDs对十二指肠溃疡治疗效果显著,可减轻患者临床症状,降低炎症反应,改善肠胃功能。

关键词: 芩连愈疡汤, 非甾体类抗炎药物, 十二指肠溃疡, 胃蛋白酶Ⅰ, 人β₂防御素2

Abstract: Objective To investigate the therapeutic effect of Qinlian Yuyang decoction combined with non steroidal anti-inflammatory drugs (NSAIDs) on duodenal ulcer and its effect on pepsin Ⅰ (PG Ⅰ) and human β₂ defensin 2 (HBD-2). Methods Selected 80 duodenal ulcer patients admitted to Gansu Baiyin Central Hospital from August 2020 to May 2023, and randomly divided into observation group and control group, 40 cases in each group. The control group was treated with conventional quadruple therapy and ibuprofen for analgesia, while the observation group was treated with Qinlian Yuyang Decoction on the basis of the control group. The clinical efficacy of the two groups were compared, the changes of TCM syndrome score before and after treatment were compared, and the expression levels of PG Ⅰ and HBD-2 were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in the TCM syndrome scores related to wrist abdominal pain or fullness, nausea, stupidity, short yellow urine, dry mouth, and bitter mouth between the two groups (P>0.05). After treatment, the TCM syndrome scores related to wrist abdominal pain or fullness, nausea, stupidity, short yellow urine, dry mouth, and bitter mouth in the two groups decreased, and the observation group was lower than the control group (P<0.05). There was no significant difference in the levels of PG Ⅰ and HBD-2 between the two groups before treatment (P>0.05). After treatment, PGI and HBD-2 levels were reduced in both groups, and the observation group was lower than the control group (P<0.05). Conclusion Qinlian Yuyang decoction combined with NSAIDs has a significant therapeutic effect on duodenal ulcer, which can reduce the clinical symptoms, reduce inflammatory reaction and improve gastrointestinal function.

Key words: Qinlian Yuyang Decoction, Non steroidal anti-inflammatory drugs, Duodenal ulcer, Pepsin Ⅰ, people β Defensin 2

中图分类号:

R573.1

李彦肃. 芩连愈疡汤联合NSAIDs对十二指肠溃疡的治疗效果分析[J]. 中华养生保健, 2024, 42(10): 9-13.

LI Yan-su. Therapeutic Effect of Qinlian Yuyang Decoction Combined with NSAIDs on Duodenal Ulcer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(10): 9-13.

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