维生素C联合西咪替丁对儿童过敏性紫癜的预后相关指标及对过敏原与肾脏损害的影响

摘要/Abstract

摘要： 目的探讨维生素C联合西咪替丁对儿童过敏性紫癜的预后相关指标及对过敏原与肾脏损害的影响。方法选取2020年1月—2022年12月沭阳医院收治的80例过敏性紫癜患儿进行研究分析,应用抽签法将其分为观察组与对照组,每组40例。对照组采取常规对症治疗。观察组在对照组基础上,增加维生素C联合西咪替丁治疗。比较两组患儿白细胞介素-18（IL-18）、D-二聚体（D-D）、纤维蛋白原（FIB）相关预后指标水平变化,并分别检测两组患儿治疗前后过敏原特异性IgE抗体检测阳性率,比较两组患者治疗前后尿常规相关肾脏损害指标的表达水平。结果治疗前,两组患儿IL-18、D-D、FIB相关预后指标水平比较,差异无统计学意义（P>0.05）,治疗后,两组患儿IL-18、D-D、FIB水平降低,观察组低于对照组,差异有统计学意义（P<0.05）。治疗前,两组患儿IgE抗体阳性率比较,差异无统计学意义（P>0.05）;治疗后,观察组过敏原特异性IgE抗体检测阳性率低于对照组,差异有统计学意义（P<0.05）。治疗前,两组患儿尿白细胞、尿红细胞水平和尿蛋白阳性率比较,差异无统计学意义（P>0.05）;治疗后,两组患者尿白细胞、尿红细胞水平和尿蛋白阳性率均降低,且观察组低于对照组,差异有统计学意义（P<0.05）。结论维生素C联合西咪替丁对儿童过敏性紫癜的预后指标具有显著改善作用,且可降低过敏原特异性IgE抗体检测阳性率,减轻肾脏损害程度。

关键词: 维生素C, 西咪替丁, 儿童, 过敏性紫癜, 过敏原

Abstract: Objective To investigate the effect of vitamin C combined with cimetidine on the prognosis of children with Henoch Schonlein purpura and the impact on allergens and kidney damage. Methods A total of 80 cases of children with Henoch Schonlein purpura in Shuyang hospital from January 2020 to December 2022 were selected and analyzed. They were divided into observation group and control group by lottery, with 40 cases in each group. The control group received conventional symptomatic treatment. The observation group was treated with vitamin C combined with cimetidine on the basis of the control group. The levels of interleukin-18 (IL-18), D-Dimer (D-D) and fibrinogen (FIB) related prognostic indicators in the two groups were compared, and the positive rates of allergen specific IgE antibodies in the two groups were detected before and after treatment, and the expression levels of urine routine related renal damage indicators in the two groups were compared before and after treatment. Results There was no significant difference in the levels of IL-18, D-D and FIB related prognostic indicators between the two groups before treatment (P>0.05). After treatment, the levels of IL-18, D-D and Fib in the two groups decreased, and the observation group was lower than the control group (P<0.05); There was no significant difference in the positive rate of IgE antibody between the two groups(P>0.05). After treatment, the positive rate of allergen specific IgE antibody in the observation group was lower than that in the control group(P<0.05); There was no significant difference in the levels of urinary white blood cells, urinary red blood cells and positive rate of urinary protein between the two groups before treatment (P>0.05). After treatment, the levels of urinary white blood cells, urinary red blood cells and positive rate of urinary protein in the two groups were reduced, and the observation group was lower than the control group (P<0.05). Conclusion Vitamin C combined with cimetidine can significantly improve the prognosis of children with Henoch Schonlein purpura, reduce the positive rate of allergen specific IgE antibody detection, and reduce the degree of renal damage.

Key words: Vitamin C, cimetidine, children, allergic purpura, allergens

中图分类号:

R725.5

刘芳, 张敏, 吴红波, 颜婷婷. 维生素C联合西咪替丁对儿童过敏性紫癜的预后相关指标及对过敏原与肾脏损害的影响[J]. 中华养生保健, 2024, 42(10): 39-43.

LIU Fang, ZHANG Min, WU Hong-bo, YAN Ting-ting. Effect of Vitamin C Combined with Cimetidine on Prognosis Related Indicators and Allergen and Kidney Damage in Children with Henoch Schonlein Purpura[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(10): 39-43.

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