超声波雾化生脉注射液联合rhEGF滴眼液治疗干眼疗效及对炎症因子影响

摘要/Abstract

摘要： 目的探究超声波雾化生脉注射液联合重组人表皮生长因子（recombinant human epidermal growth factor,rhEGF）滴眼液对确诊为干眼患者的干预价值,同时探究联合治疗在降低患者泪液炎症因子水平中的有效性。方法选取2020年8月—2023年1月于通用环球西航医院接受治疗的80例干眼患者作为研究对象,按照随机数表法将其区分为研究组（n=40,接受超声波雾化联合rhEGF治疗）与对照组（n=40,单纯接受rhEGF治疗）,比较两组患者治疗效果,治疗前后泪膜破裂时间（break-up time,BUT）、泪液分泌长度、角膜荧光素染色（fluorescein staining,FL）评分差异,比较两组患者治疗前后免疫学指标白细胞介素-6（interleukin-6,IL-6）、肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）水平差异,评估两组患者治疗前后自觉症状评分差异。结果研究组总干预有效率高于对照组,差异有统计学意义（P<0.05）;治疗后研究组的泪膜BUT水平和泪液分泌长度高于对照组,角膜FL评分低于对照组,差异有统计学意义（P<0.05）;治疗后研究组IL-6和TNF-α水平显著低于对照组,差异有统计学意义（P<0.05）;研究组治疗后自觉症状评分低于对照组,差异有统计学意义（P<0.05）。结论超声雾化生脉注射液联合rhEGF对干眼具有较好的治疗效果,能够促进泪膜稳定性和泪液分泌,缓解角膜损伤,还有助于改善患者炎症反应状态,提高其自我症状评分,值得临床应用。

关键词: 超声波雾化, 生脉注射液, 重组人表皮生长因子, 干眼, 临床效果, 炎症因子

Abstract: Objective Explore the intervention value of ultrasound nebulization combined with recombinant human epidermal growth factor (rhEGF) eye drops in patients diagnosed with dry eye syndrome, and explore the effectiveness of combined therapy in reducing tear inflammatory factor levels in patients. Methods 80 patients with dry eye who received treatment at General Western Airlines Hospital from August 2020 to January 2023 were selected as the study subjects. They were randomly divided into the study group (n=40, receiving ultrasound nebulization combined with rhEGF treatment) and the control group (n=40, receiving rhEGF treatment alone) using a random number table method. The treatment effects of the two groups were compared, including tear film break-up time (BUT), tear secretion length, and corneal fluorescence staining (FL) scores, immunological indicators of interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α) , and subjective symptom scores between the two groups of patients before and after treatment. Results The total effective rate of intervention in the study group was 97.50%, which was higher than 85.00% in the control group (P<0.05); After treatment, the BUT level of the study group patients was higher than that of the control group, and the tear secretion length and corneal FL score were lower than those of the control group (P<0.05); IL-6 and TNF- α levels of patients in study group was significantly lower than that of the control group after treatment (P<0.05); The self-conscious symptom score of the study group patients after treatment was lower than that of the control group (P<0.05). Conclusion Ultrasound atomization combined with rhEGF has a good therapeutic effect on dry eye syndrome, which can promote tear film stability, reduce tear secretion and corneal damage, and also help improve the patient's inflammatory state and improve their self symptom score. It has certain promotion and application value.

Key words: Ultrasonic atomization, recombinant human epidermal growth factor, dry eye, clinical effect, inflammatory factor

中图分类号:

R771

王红艳. 超声波雾化生脉注射液联合rhEGF滴眼液治疗干眼疗效及对炎症因子影响[J]. 中华养生保健, 2024, 42(10): 186-189.

WANG Hong-yan. Efficacy of Ultrasonic Atomization Combined with rhEGF Eye Drops and Its Effects on Inflammatory Factors[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(10): 186-189.

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