“筋骨并治”理论下膝痹汤联合中药熏洗治疗肝肾亏虚型膝骨性关节炎的临床疗效及对疾病严重程度影响

摘要/Abstract

摘要： 目的探讨“筋骨并治”理论下膝痹汤联合中药熏洗治疗肝肾亏虚型膝骨性关节炎的临床疗效及对疾病严重程度的影响。方法选取扬州市中医院2022年7月—2023年6月收治的80例肝肾亏虚型膝骨性关节炎患者作为研究对象,按照随机数表法将患者分为对照组、观察组,每组40例。对照组口服塞来昔布胶囊（1次/d,0.2 g/次）治疗,观察组采用“筋骨并治”理论下膝痹汤联合中药熏洗治疗（膝痹汤1剂/d,早晚分服;中药熏洗膝关节,2次/d,0.5 h/次）。对比两组患者临床治疗效果、WOMAC指数及ISOA指数,并对比两组患者治疗前后血清超氧化物歧化酶（SOD）、一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）水平以及疼痛消失时间和关节功能改善时间。结果观察组治疗总有效率高于对照组,差异有统计学意义（P<0.05）;治疗后两组患者OMAC指数及ISOA指数均降低,且观察组低于对照组,差异有统计学意义（P<0.05）;治疗后两组患者SOD水平均升高,NO、TNF-α水平均降低,且观察组SOD水平高于对照组,观察组NO、TNF-α水平低于对照组,差异有统计学意义（P<0.05）;观察组患者疼痛消失时间及关节功能改善时间明显短于对照组,差异有统计学意义（P<0.05）。结论 “筋骨并治”理论下膝痹汤联合中药熏洗可改善肝肾亏虚型膝骨性关节炎的临床疗效,减轻其病情严重程度,提升膝关节功能,改善氧化因子及炎症因子水平,缩短患者临床症状持续时间。

关键词: 筋骨并治, 膝痹汤, 中药熏洗, 肝肾亏虚型, 膝骨性关节炎

Abstract: Objective To explore the clinical efficacy and impact on the severity of knee osteoarthritis caused by liver and kidney deficiency treated with knee bi decoction combined with traditional Chinese medicine fumigation and washing under the theory of "treating both muscles and bones". Methods A total of 80 patients with knee osteoarthritis of liver and kidney deficiency type admitted to our hospital from July 2022 to June 2023 were selected as the research subjects. The random number table method was used as the guiding basis to group the patients, and the specific groups were control group, observation group, with 40 cases in each group. The control group was treated with oral Celecoxib capsules (0.2 g once daily), while the observation group was treated with XiBi Tang combined with Chinese herbal fumigation (one dose of XiBi Tang daily, divided into morning and evening; Chinese herbal fumigation of the knee joint twice daily, half an hour each time) under the theory of "tendon and bone treatment". The clinical treatment effects, WOMAC index and ISOA indexof the two groups of patients were compared. The serum superoxide dismutase (SOD), nitric oxide (NO) and tumor necrosis factor (TNF) were compared between the two groups before and after treatment-α (TNF-α) Expression level and time for pain relief and joint function improvement. Results In terms of total effective rate of treatment, the observation group was higher than the control group (P<0.05). After treatment, the OMAC index and ISOA index of both groups of patients decreased, and the observation group was lower than the control group (P<0.05). After treatment, the SOD levels of both groups of patients increased, and the observation group was higher than the control group, including NO and TNF- α, the levels all decreased, and the observation group was lower than the control group (P<0.05). The time for pain relief and joint function improvement in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Under the theory of "treating both muscles and bones", the combination of knee bi decoction and traditional Chinese medicine fumigation can improve the clinical efficacy of knee osteoarthritis with liver and kidney deficiency, reduce the severity of the condition, enhance knee joint function, improve levels of oxidative and inflammatory factors, and shorten the duration of clinical symptoms in patients.

Key words: combined treatment of muscles and bones, xibi tang, traditional chinese medicine fumigation and washing, liver and kidney deficiency type, knee osteoarthritis

中图分类号:

R274.9

王韶光, 田涛, 傅强, 朱健奎, 殷韶健, 仇宋明. “筋骨并治”理论下膝痹汤联合中药熏洗治疗肝肾亏虚型膝骨性关节炎的临床疗效及对疾病严重程度影响[J]. 中华养生保健, 2024, 42(1): 8-11.

WANG Shao-guang, TIAN Tao, FU Qiang, ZHU Jian-kui, YIN Shao-jian, QIU Song-ming. Clinical Efficacy and Impact on Disease Severity of Knee Osteoarthritis with Liver and Kidney Deficiency Treated with Knee Bi Decoction Combined with Traditional Chinese Medicine Fumigation and Washing under the Theory of "Combined Treatment of Muscles and Bones"[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(1): 8-11.

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