彩色多普勒超声联合X线钼靶对乳腺癌的诊断分析

摘要/Abstract

摘要： 目的研究彩色多普勒超声联合X线钼靶对乳腺癌的诊断价值。方法选择2020年1月—2023年3月赤峰市医院收治的82例疑似乳腺癌患者作为研究对象,所有患者均进行彩超与X线钼靶检查,观察比较彩色多普勒超声、X线钼靶单独及联合应用的诊断效能。结果病理检查显示：乳腺癌45例（54.88%）,乳腺良性病变37例（45.12%）。以病理检查为金标准,则彩超检查的准确率、灵敏度、特异度、阳性预测值、阴性预测值分别为71.95%、66.67%、78.38%、78.95%、65.91%,X线钼靶检查的准确率、灵敏度、特异度、阳性预测值、阴性预测值分别为80.49%、80.00%、81.08%、83.72%、76.92%,联合检查的准确率、灵敏度、特异度、阳性预测值、阴性预测值分别为95.12%、93.33%、97.30%、97.67%、92.31%,彩超联合X线钼靶检查诊断乳腺癌的准确率、灵敏度、特异度、阳性预测值及阴性预测值均高于单一检查,差异有统计学意义（P<0.05）。结论彩超联合X线钼靶检查可有效提高乳腺癌诊断效能,具有较高的应用价值。

关键词: 乳腺癌, 彩色多普勒超声, X线钼靶

Abstract: Objective To study the diagnostic value of color Doppler ultrasound combined with X-ray molybdenum target in breast cancer. Methods The study subjects were 82 suspected breast cancer patients admitted to our hospital from January 2020 to March 2023. All patients were examined by color Doppler ultrasound and X-ray molybdenum target. The diagnostic efficacy of color Doppler ultrasound and X-ray molybdenum target alone and in combination was observed and compared. Results Pathological examination showed that there were 45 cases of breast cancer (54.88%) and 37 cases of benign breast lesions (45.12%). Using pathological examination as the gold standard, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of color Doppler ultrasound examination are 71.95%, 66.67%, 78.38%, 78.95%, and 65.91%, respectively. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of X-ray molybdenum target examination are 80.49%, 80.00%, 81.08%, 83.72%, and 76.92%, respectively. The accuracy, sensitivity, specificity, positive predictive value and negative predictive values of combined examination are 95.12%, 93.33%, 97.30%, 97.67% and 92.31% respectively. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of color ultrasound combined with X-ray molybdenum target examination in the diagnosis of breast cancer were higher than those of single examination, statistically significant difference (P<0.05). Conclusion Color Doppler ultrasound combined with X-ray molybdenum target examination can effectively improve the diagnostic efficiency of breast cancer, and has high application value.

Key words: breast cancer, color Doppler ultrasound, X-ray molybdenum target

中图分类号:

R445

刘立强, 张伟. 彩色多普勒超声联合X线钼靶对乳腺癌的诊断分析[J]. 中华养生保健, 2024, 42(1): 43-46.

LIU Li-qiang, ZHANG Wei. Diagnosis of Breast Cancer by Color Doppler Ultrasound Combined with X-ray Molybdenum Target[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(1): 43-46.

参考文献

[1] 王英颖,刘景哲,火忠,等.乳腺叶状肿瘤的乳腺钼靶X线摄影、彩色多普勒超声表现与病理对照研究[J].实用放射学杂志,2020,36(5):745-747,771.
[2] ATTARI F, HAZIM H, ZANDI A, et al.Circumventing paclitaxel resistance in breast cancer cells using a nanoemulsion system and determining its efficacy via an impedance biosensor[J]. Analyst,2021,146(10):3225-3233.
[3] 刘隽悦,彭东,田艺,等.彩色多普勒超声联合乳腺钼靶X线诊断乳腺癌患者的临床应用及其诊断效能分析[J].中国数字医学,2020,15(4):111-113.
[4] 乐坚,刘雅静,高毅,等.常规超声假阴性与钼靶X线假阴性乳腺癌的临床病理特征比较[J].中国超声医学杂志,2020,36(9):792-794.
[5] AHMAD S, HE Q, WILLIAMS K P, et al.Identification of a Triple Drug Combination That Is Synergistically Cytotoxic for Triple-Negative Breast Cancer Cells Using a Novel Combination Discovery Approach[J]. SLAS Discov,2020,25(8):923-938.
[6] 乌兰,陈宁,朱晓龙.X线钼靶、CT检测及超声检测致密型腺体乳腺癌早期诊断中的应用价值对比[J].中国CT和MRI杂志,2021,19(10):87-90.
[7] 车凌祥,黄晴.彩色多普勒超声超声弹性成像及X线钼靶检查在健康体检妇女乳腺癌筛查中的方案优化[J].中国妇幼保健,2021,36(14):3385-3388.
[8] 梁兴明,黄世海,汪轶亭,等.钼靶X射线与彩色多普勒超声对乳腺癌的影像学特征及诊断价值比较分析[J].现代生物医学进展,2022,22(17):3319-3323.
[9] 田建,陈高松,程好堂,等.彩色多普勒超声与乳腺X线摄影联合MRI在乳腺癌诊断中的临床应用[J].医学影像学杂志,2022,32(8):1418-1421.
[10] 陈丽芬,赵璐,陈佳琦,等.血清糖类抗原153、糖类抗原125、细胞角蛋白19片段联合彩色多普勒高频超声检查在早期乳腺癌诊断中的价值[J].中国卫生检验杂志,2020,30(2):215-218.
[11] MOORMAN S E H, PUJARA A C, SAKALA M D, et al. Annual Screening Mammography Associated With Lower Stage Breast Cancer Compared With Biennial Screening[J].AJR Am J Roentgenol,2021,217(1):40-47.
[12] 汪瑞,周军.糖类抗原153、人附睾分泌蛋白4联合高频超声及钼靶在乳腺癌早期诊断中的应用研究[J].广西医科大学学报,2020,37(8):1531-1536.
[13] 王妍,郭丹,陈小璐,等.动态增强MRI联合钼靶X线对乳腺癌保乳术术前评估的价值研究[J].中国肿瘤临床与康复,2021,28(7):831-834.
[14] 张睿,周泉,陶莉.钼靶X线联合超声在乳腺导管癌中的诊断价值与ER、PR及Her-2关系分析[J].中国临床医学影像杂志,2021,32(4):288-290.
[15] 冯华梅,刘颖,宋倩.早期乳腺导管内癌钼靶X线超声造影表现及与免疫组化HER-2nm-23表达的关系[J].河北医学,2021,27(1):141-146.
[16] 王俊芳,余小琴,陈金华.彩色多普勒超声、钼靶X线摄影与磁共振成像(MRI)在触诊阴性乳腺癌诊断中的应用价值对比分析[J].现代医用影像学,2020,29(7):1310-1312.