千金苇茎汤加减方治疗小儿肺炎支原体肺炎（痰热闭肺证）的疗效及对血清因子的影响

摘要/Abstract

摘要： 目的探究与分析千金苇茎汤加减方治疗小儿肺炎支原体肺炎（痰热闭肺证）的疗效及对血清因子的影响。方法选择2018年12月—2020年12月山东大学附属儿童医院收治的126例小儿肺炎支原体肺炎患者作为研究对象,采取随机数表法分为对照组和观察组,每组63例。两组均采取基础治疗,观察组加用千金苇茎汤加减方治疗,比较两组临床效果。结果观察组临床总有效率高于对照组,差异有统计学意义（P<0.05）。治疗后,两组咯痰、气喘、发热及唇绀评分均较治疗前降低,且观察组治疗后咯痰、气喘、发热及唇绀评分较对照组低,差异有统计学意义（P<0.05）。观察组胸片阴影消失时间、肺部湿啰音消失时间、咳嗽消失时间以及退热时间均较对照组早,差异有统计学意义（P<0.05）。治疗后,两组白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、D-二聚体、单核细胞趋化蛋白-4（MCP-4）、可溶性白细胞介素2受体（sIL-2R）水平均较治疗前降低,且观察组治疗后IL-2、IL-4、D-二聚体、MCP-4、sIL-2R水平均较对照组低,差异有统计学意义（P<0.05）。两组患儿在用药期间均未出现明显的消化道反应或肝肾功能障碍。结论千金苇茎汤加减方治疗小儿肺炎支原体肺炎（痰热闭肺证）临床效果较好,明显缩短了主要症状恢复时间,调节了血清因子水平,且用药期间无明显不良反应,安全性可获得保障。

关键词: 千金苇茎汤, 痰热闭肺证, 小儿肺炎支原体肺炎, 疗效, 血清因子, 安全性

Abstract: Objective To explore and analyze the curative effect of Qianjin Weijing Decoction in the treatment of children with mycoplasma pneumoniae pneumonia (phlegm-heat closing lung syndrome) and its effect on serum factors. Methods A total of 126 cases of pediatric mycoplasma pneumoniae pneumonia admitted to Shandong University Affiliated Children's Hospital from December 2018 to December 2020 were divided into groups by random number table method, with 63 cases in each group. Both groups received basic treatment, and the observation group was treated with Qianjin Weijin decoction plus Jiawei prescription, and the clinical effects of the two groups were compared. Results Compared with the control group,the observation group had higher total clinical efficiency, and the disappearance time of major symptoms was shortened, and the difference was statistically significant (P<0.05). Compared with the control group, the TCM syndrome score and serum factor value were lower in the observation group (P<0.05). There was no obvious gastrointestinal reaction or liver and kidney dysfunction in the two groups, and the difference was not significant (P>0.05). Conclusion Qianjin Weijing Decoction has a good clinical effect in the treatment of children with mycoplasma pneumoniae pneumonia (phlegm-heat closed lung syndrome), significantly shortens the recovery time of main symptoms, regulates serum factor levels, and has no obvious adverse reactions during the medication period, and its safety is acceptable. Get guaranteed.

Key words: Qianjin Weijing Decoction, phlegm-heat closing lung syndrome, mycoplasma pneumoniae pneumonia in children, efficacy, serum factors, safety

中图分类号:

R272

曲晓红. 千金苇茎汤加减方治疗小儿肺炎支原体肺炎（痰热闭肺证）的疗效及对血清因子的影响[J]. 中华养生保健, 2024, 42(1): 30-33.

QU Xiao-hong. Curative Effect of Qianjin Weijing Decoction in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia (Phlegm-Heat Closing Lung Syndrome) and Its Effect on Serum Factors[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(1): 30-33.

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