参芪降糖胶囊联合甲钴胺治疗糖尿病周围神经病变的效果观察

摘要/Abstract

摘要： 目的研究参芪降糖胶囊联合甲钴胺对糖尿病周围神经病变的治疗效果。方法选择2020年1月—2022年12月青岛市即墨区第二人民医院收治的136例糖尿病周围神经病变患者作为研究对象,采用抽签法随机分为对照组和观察组,每组68例。对照组采用甲钴胺治疗,观察组采用参芪降糖胶囊联合甲钴胺治疗。两组均治疗2个月,评估两组的临床疗效和症状评分,检测两组的血清C肽（C-P）、胰岛素样生长因子-1（IGF-1）、内皮素-1（ET-1）和胱抑素（Cys-C）水平。结果观察组治疗有效率明显高于对照组,差异有统计学意义（P<0.05）。治疗后,两组的肌肉萎缩、四肢疼痛、肢体麻木、感觉减退和四肢发凉症状评分均明显降低,且观察组明显低于对照组,差异有统计学意义（P<0.05）。治疗后,两组的血清C-P、IGF-1水平均明显升高,血清ET-1和Cys-C水平均明显降低,且观察组的血清C-P、IGF-1水平明显高于对照组,血清ET-1和Cys-C水平明显低于对照组,差异有统计学意义（P<0.05）。结论参芪降糖胶囊联合甲钴胺对糖尿病周围神经病变有显著的效果,能明显减轻症状,其作用机制可能与血清神经营养因子水平的升高和ET-1、Cys-C水平的降低有关。

关键词: 参芪降糖胶囊, 甲钴胺, 糖尿病周围神经病变

Abstract: Objective To investigate the effect of Shenqi Jiangtang Capsule and Mecobalamin on diabetes Peripheral Neuropathy. Methods Selected 136 cases of patients with diabetes Peripheral Neuropathy who were treated in our hospital from January 2020 to December 2022, divided into two groups randomly. The control group was treated with mecobalamin, while the observation group was treated with Shenqi Jiangtang capsule combined with mecobalamin. Both groups were treated for 2 months.The scores of were evaluated, and the levels of serum C-peptide (C-P), insulin-like growth factor-1 (IGF-1), endothelin-1 (ET-1) and cystatin (Cys-C) were measured. Results The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the scores of muscle atrophy, limb pain, limb numbness, hypoesthesia and limb cooling symptoms in the two groups were significantly lower (P<0.05), and the scores of muscle atrophy, limb pain, limb numbness, hypoesthesia and limb cooling symptoms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of serum C-P, IGF-1 were significantly increased (P<0.05), and the levels of serum ET-1 and Cys-C were significantly decreased (P<0.05). The levels of serum C-P, IGF-1 in the observation group were significantly higher than those in the control group (P<0.05), and the levels of serum ET-1 and Cys-C were significantly lower than those in the control group (P<0.05). Conclusion shenqi Jiangtang Capsule combined with mecobalamin has a significant effect on diabetes peripheral neuropathy and can significantly alleviate symptoms. Its mechanism may be related to the increase of serum neurotrophic factor levels and the decrease of ET-1 and Cys-C levels.

Key words: Shenqi Jiangtang Capsule, methylcobalamin, diabetes peripheral neuropathy

中图分类号:

R945

刘元超, 王秀娟, 刘建新. 参芪降糖胶囊联合甲钴胺治疗糖尿病周围神经病变的效果观察[J]. 中华养生保健, 2024, 42(1): 26-29.

LIU Yuan-chao, WANG Xiu-juan, LIU Jian-xin. Effect of Shenqi Jiangtang Capsule and Mecobalamin on diabetes Peripheral Neuropathy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(1): 26-29.

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