酚妥拉明局部封闭联合活血消肿膏治疗多巴胺外渗组织损伤的临床研究

中华养生保健 ›› 2023, Vol. 41 ›› Issue (8): 13-16.

酚妥拉明局部封闭联合活血消肿膏治疗多巴胺外渗组织损伤的临床研究

王亚喜¹, 王晓杰¹, 郭文静¹, 庞旭峰^2,*

1.青岛大学护理学院,山东青岛,266021;
2.青岛大学附属医院护理院感部,山东青岛,266000

出版日期:2023-04-16 发布日期:2023-04-11
通讯作者: ^*庞旭峰,E-mail：18661808973@163.com。
作者简介:王亚喜（1996—）,女,汉族,籍贯：河北省衡水市,硕士研究生在读,研究方向：重症护理。

Clinical Study of Phentolamine Partial Occlusion Combined with Huoxuexiaozhong Ointment in the Treatment of Dopamine Extravasation Tissue Damage

WANG Ya-xi¹, WANG Xiao-jie¹, GUO Wen-jing¹, PANG Xu-feng^2,*

1. School of Nursing,Qingdao University, Qingdao Shandong, 266021, China;
2. Department of Hospital-acquired Infection Control, The Affiliated Hospital of Qingdao University, Qingdao Shandong, 266000, China

Online:2023-04-16 Published:2023-04-11

摘要/Abstract

摘要： 目的探究酚妥拉明早期局部封闭联合活血消肿膏治疗因多巴胺外渗所导致的局部组织损伤的治疗作用及效果。方法收集青岛市3所三级甲等医院重症监护室2020年7月—2022年7月经外周静脉泵入多巴胺发生外渗引起组织损伤的患者80例,应用随机数表法将患者分为干预组（活血消肿膏组）和对照组（50%硫酸镁组）,每组40例。两组患者采用相同的局部封闭方法,干预组应用活血消肿膏外敷,对照组采用50%硫酸镁外敷,每4小时更换敷料1次,每8小时观察两组治疗效果,患者出院或死亡时对其组织损伤程度再次进行评估,比较两组患者治疗后的美国食品和药品管理局（FDA）皮肤损伤评分,并进行多元线性回归分析。结果干预组多巴胺外渗治疗后的FDA皮肤损伤评分显著低于对照组,差异有统计学意义（P<0.05）,多元线性回归分析的结果显示活血消肿膏降低FDA皮肤损伤评分的效果是50%硫酸镁的2.85倍,临床效果显著。结论酚妥拉明早期局部封闭联合活血消肿膏治疗多巴胺外渗组织损伤,可显著降低外渗皮肤出现炎症及坏死的发生率。

关键词: 多巴胺, 酚妥拉明, 活血消肿膏

Abstract: Objective To explore the therapeutic effect of phentolamine early local closure combined with Huoxuexiaozhong ointment in the treatment of local tissue damage caused by dopamine extravasation. Methods A total of 80 patients with tissue damage caused by extravasation of dopamine through peripheral intravenous pumping were collected from July 2020 to July 2022 in the intensive care units of 3 hospitals in Qingdao. These patients were randomly divided into an intervention group (Huoxuexiaozhong ointment group, 40) and a control group ( 50% magnesium sulfate group, 40). The two groups of patients were treated with the same partial sealing method. The intervention group was applied with external application of Huoxuexiaozhong ointment. The control group was use to external application 50% magnesium sulfate. Change the dressing every 4 h/time. We observed the therapeutic effect of the two groups every 8 hours. The degree of tissue damage was reassessed until they are discharged or died, and the US Food and Drug Administration (FDA) skin damage scores were compared between the two groups after treatment, and carry out multiple linear regression analysis. Results The FDA score of the intervention group was significantly lower than that of the control group (P<0.05). The results of multiple linear regression analysis showed that the ability of Huoxuexiaozhong ointment can reduce the FDA skin damage score was 2.85 times that of 50% magnesium sulfate, and the clinical effect was significant. Conclusion Early partial closure of phentolamine combined with Huoxuexiaozhong ointment in the treatment of dopamine extravasation tissue damage can significantly reduce the incidence of inflammation and necrosis of extravasated skin.

Key words: dopamine, phentolamine, Huoxuexiaozhong ointment

中图分类号:

R472

王亚喜, 王晓杰, 郭文静, 庞旭峰. 酚妥拉明局部封闭联合活血消肿膏治疗多巴胺外渗组织损伤的临床研究[J]. 中华养生保健, 2023, 41(8): 13-16.

参考文献

[1] STRATTON L, BERLIN D A, ARBO J E.Vasopressors and inotropes in Sepsis[J]. Emerg Med Clin North Am,2017,35(1):75-91.
[2] HEIDEMANN L, NATHANI N, SAGANA R, et al.A Contemporary Assessment of Mechanical Complication Rates and Trainee Perceptions of Central Venous Catheter Insertion[J]. Journal of Hospital Medicine,2017,12(8):646-651.
[3] 李艳宏,郭波,宋晓丹.赛肤润联合硫酸镁治疗多巴胺外渗致静脉炎的护理体会[J].中国实用医药,2018,13(33):102-103.
[4] 倪乐凤,龚卫娟,刘林,等.非化疗药物外渗的原因分析及对策[J].实用临床医药杂志,2022,26(6):145-148.
[5] 梁娟. 50％硫酸镁湿敷护理预防输注盐酸多巴胺致静脉炎的体会[J].首都食品与医药,2019(7):183.
[6] 曾武雄,徐海锦,黄秉纲,等.活血消肿膏治疗四肢外伤性软组织肿胀疗效观察[J].中国现代医生,2013,51(31):107-108.
[7] 杨海燕. 活血消肿膏不同剂量外敷治疗急性软组织损伤的临床疗效对比研究[J].中西医结合心血管病电子杂志,2020,8(11):151-152,156.
[8] YANG J C, CHANG A E, BAKER A R, et al.Randomized Prospective Study of the Benefit of Adjuvant Radiation Therapy in the Treatment of Soft Tissue Sarcomas of the Extremity[J]. Journal of Clinical Oncology,1998,16(1):197-203.
[9] 李小寒,尚少梅.基础护理学(第6版)[M].北京:人民卫生出版社,2017:417-418.
[10] LEWIS T, MERCHAN C, ALTSHULER D, et al.Safety of the peripheral administration of vasopressor agents[J]. Journal of Intensive Care Medicine,2019,34(1): 26-33.
[11] 刘晓霞,侯文雅,郭晓迪,等.基于木瓜蛋白酶的多巴胺比色检测法研究[J].分子科学学报,2022,38(5):441-447.
[12] 柴士花,王莉娟,邱明月.95%酒精联合黄连膏湿敷治疗多巴胺外渗护理观察[J].中医临床研究,2017,9(17):124-126.
[13] BOYAR V, COLLEEN G.Reducing Peripheral Intravenous Catheter Extravasation in Neonates: A Quality Improvement Project[J]. J Wound Ostomy Continence Nurs,2021,48(1): 31-38.
[14] 杨宝峰,苏定冯,周宏灏,等.药理学(第9版)[M].北京:人民卫生出版社,2018:91-92.
[15] 黄湘琳,曹芳,邹星乐.多磺酸黏多糖乳膏用于预防静脉炎及高危药物外渗的护理效果[J].中西医结合护理(中英文),2021,7(8):82-84.
[16] 王振,张晓刚,宋敏,等.外用中药制剂治疗急性软组织损伤的动物实验研究现状及进展[J].中国中医急症,2016,25(11):2104-2107.