从三焦的形质与功能探讨恶性肿瘤淋巴道转移的病机

中华养生保健 ›› 2023, Vol. 41 ›› Issue (6): 22-25.

从三焦的形质与功能探讨恶性肿瘤淋巴道转移的病机

范国栋¹, 西梦婵¹, 焦安男², 陈杨^2,*

1.安徽中医药大学研究生院,安徽合肥,230038;
2.安徽医科大学第一附属医院中西医结合肿瘤科,安徽合肥,230022

出版日期:2023-03-16 发布日期:2023-03-15
通讯作者: *陈杨,E-mail：2250230244@qq.com。
作者简介:范国栋（1997—） ,男,汉族,籍贯：安徽省安庆市,硕士研究生在读,研究方向：中西医结合防治恶性肿瘤。
基金资助:
国家自然科学基金（82004314）; 安徽医科大学第一附属医院临床研究启动计划（LCYJ2021YB017）

Exploring the Pathogenesis of Lymphatic Tract Metastasis in Malignant Tumors from the Form and Function of Triple Energizer

FAN Guo-dong¹, XI Meng-chan¹, JIAO An-nan², CHEN Yang^2,*

1. Graduate School of Anhui University of Chinese Medicine,Hefei Anhui, 230038, China;
2. Department of Integrated Chinese and Western Medicine Oncology, The First Affiliated Hospital of Anhui Medical University,Hefei Anhui, 230022,China

Online:2023-03-16 Published:2023-03-15

摘要/Abstract

摘要： 恶性肿瘤淋巴转移是肿瘤患者病情进展的重要因素,严重威胁患者生命健康。中医学对三焦的形质与功能有着深入的认识,认为三焦在形质上为“膜”性四通管道,通达机体周身布散精微,外排污浊;在功能上总司全身气机气化,化生营卫,抵御外邪。近代发现三焦的形质和功能与肿瘤淋巴道转移关系密切,三焦的病理形态是肿瘤转移通道,其气化功能异常是肿瘤转移关键。结合三焦理论,认为三焦气机畅通、三焦水道通利则痰饮瘀毒不得蓄积,营卫之气畅达周身,而邪难留存,由此提出“调气机”“利水道”为防治恶性肿瘤淋巴道转移的关键。“三焦形质功能”的异常是肿瘤淋巴道转移的核心,依据三焦理论及其相关的治则治法可以指导肿瘤的治疗,期待对中医临床治疗肿瘤有所裨益。

关键词: 三焦, 恶性肿瘤, 淋巴转移, 病机, 气化

Abstract: Lymphatic metastasis of malignant tumor is an important factor in the progression of tumor patients. The existing treatment effect is limited and the prognosis is poor, which seriously threatens the life and health of patients. Traditional Chinese medicine has an in-depth understanding of the shape, quality and function of triple energizer, and holds that triple energizer is a “membrane” four-way pipeline in shape and quality, which can reach the body with subtle distribution and discharge of dirt; in function, the general manager of the whole body is gasified, chemically, and defends against external evils. Recently, it has been found that the shape, quality and function of triple energizer are closely related to tumor lymphatic metastasis. The pathological form of triple energizer is the pathway of tumor metastasis, and its abnormal gasification function is the key to tumor metastasis. Combined with the triple energizer theory, it is considered that if the triple energizer qi machine is unobstructed and the triple energizer waterway is clear, the phlegm and blood stasis cannot be accumulated, the qi of Ying and Wei reaches the whole body, but the evil is difficult to remain, so it is put forward that “air regulator” and “Liquan channel” are the key to the prevention and treatment of lymphatic metastasis of malignant tumor. The abnormality of trifocal function is the core of tumor lymphatic metastasis. According to the triple energizer theory and its related treatment principles, it can guide the treatment of tumors, which is expected to be beneficial to the clinical treatment of tumors in traditional Chinese medicine.

Key words: triple energizer, malignant tumor, lymphatic metastasis, pathogenesis, qi gasification

中图分类号:

范国栋, 西梦婵, 焦安男, 陈杨. 从三焦的形质与功能探讨恶性肿瘤淋巴道转移的病机[J]. 中华养生保健, 2023, 41(6): 22-25.

FAN Guo-dong, XI Meng-chan, JIAO An-nan, CHEN Yang. Exploring the Pathogenesis of Lymphatic Tract Metastasis in Malignant Tumors from the Form and Function of Triple Energizer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(6): 22-25.

参考文献 26

[1]	SUNG H, FERLAY J, SIEGEL R L, et al.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin,2021,71(3):209-249.
[2]	李鹏,申翼.肿瘤的淋巴管生成和淋巴血管重塑[J].医学研究生学报,2015,28(6):646-649.
[3]	王鹏飞. 扶正安中汤联合化疗治疗气阴两虚型转移性结直肠癌的回顾性研究[D].合肥:安徽中医药大学,2021.
[4]	姚荷生,姚梅龄,姚芷龄.三焦焦膜病辨治[J].江西中医学院学报,2007,19(4):1-5.
[5]	和靖,李炜弘,欧阳双,等.基于陈潮祖“膜腠三焦”学说再探三焦的形质与功能[J].中华中医药杂志,2021,36(4):1969-1971.
[6]	满君. 从三焦“膜性四通管道”论治肺结节病的理论及临床研究[D].北京:北京中医药大学,2021.
[7]	童武兰,张珑琼,欧云娜,等.论三焦的“三腔”解剖定位[J].光明中医,2015,30(2):361-362.
[8]	LAWRENCE L, TRETBAR, ChERYL L Morgan, et al. Lymphedema[M].Springer,London:2008-01-01.
[9]	STACKER S A, Williams S P, Karnezis T, et al.Lymphan-giogenesis and lymphatic vessel remodelling in cancer[J].Nat Rev Cancer,2014, 14(3):159-172.
[10]	CAO Y.Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis[J]. Nat Rev Cancer,2005,5(9):735-743.
[11]	朱潇雨,吴喆,高瑞柯,等.基于“三焦者,原气之别使”探究阳虚与恶性肿瘤腹膜转移关系[J].中医杂志,2021,62(2):182-184.
[12]	张晓梅,姜良铎,肖培新.三焦膜性管道论[J].环球中医药,2019, 12(7):1054-1056.
[13]	叶乃菁,刘宣,李琦.癌毒转移的中医理论探讨[J].中医杂志,2014, 55(3):185-188.
[14]	伊日贵,徐晓艳,李时荣.肿瘤侵袭转移机制研究进展[J].中华实用诊断与治疗杂志,2014,28(10):937-939.
[15]	徐培平,符林春,张奉学,等.试论中医营卫之气与慢性乙型肝炎免疫发病及治疗的关系[J].中西医结合肝病杂志,2011,21(5):287-288.
[16]	李具双. 三焦与营卫气生成关系浅谈[J].浙江中医药大学学报,2017,41(1):46-48.
[17]	姜天玥,王文萍,喻明.从卫气理论探讨表皮生长因子受体抑制剂不良反应的病机与治疗[J].环球中医药,2021,14(12):2179-2183.
[18]	MLECNIK B, BINDEA G, KIRILOVSKY A, et al. The tumor microenvironment and immunoscore are critical determinants of dissemination to distant metastasis[J]. Sci Transl Med,2016, 8(327): 327ra26.
[19]	DIEU-NOSJEAN M C, GIRALDO N A, KAPLON H, et al. Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers[J]. Immunol Rev,2016,271(1):260-75.
[20]	SAUTÈS-FRIDMAN C, VERNEAU J, SUN C M, et al. Tertiary lymphoid structures and B cells: Clinical impact and therapeutic modulation in cancer[J]. Semin Immunol,2020,48:101406.
[21]	何伟. 从三焦气化论肿瘤的中医病机[J].北京中医药大学学报, 2018,41(4):274-278.
[22]	顾恪波,王逊,何立丽,等.孙桂芝从三焦论治恶性肿瘤经验浅析[J].中国中医药信息杂志,2012,19(12):87-88.
[23]	杨亚平,胡守友.从三焦气化试论恶性肿瘤的防治[J].浙江中医药大学学报,2019,43(9):945-948.
[24]	赖宇鑫. 姜良铎教授从状态论治肺腺癌术后经验总结及其常用用药规律研究[D].北京:北京中医药大学,2021.
[25]	魏华民,朱瑞丽,刘瑞,等.升降三焦气机在肿瘤化湿治法中的应用[J].世界中医药,2019,14(2):495-499.
[26]	杨剑横,储真真.升降散治疗肿瘤临床运用举隅[J].世界中西医结合杂志,2016,11(9):1290-1292,1296.