系统性红斑狼疮焦虑抑郁严重程度彩色脑地形图特点与外周血白介素-6和5-羟色胺相关分析

摘要/Abstract

摘要： 目的探讨系统性红斑狼疮（SLE）伴焦虑抑郁严重程度与外周血白介素-6（IL-6）、5-羟色胺（5-HT）的相关性及彩色脑地形图特点,旨在为临床结合脑地形图和外周血特点判断患者的焦虑抑郁情绪提供依据。方法评估107例2019年8月—2020年4月在哈尔滨医科大学附属第二医院住院治疗的SLE患者的抑郁自评量表（SDS）、焦虑自评量表（SAS）;分析外周血的5-HT、IL-6滴度及彩色脑电地形图异常状态与SAS、SDS评分的相关性。结果 5-HT和IL-6滴度与SDS评分差异有统计学意义（P<0.05）,中、重度抑郁5-HT滴度明显小于轻度抑郁,中、重抑郁IL-6滴度大于无抑郁和轻度抑郁,其中47例彩色脑地形图中度异常伴抑郁倾向达95%。结论 SLE外周血中的5-HT、IL-6与抑郁情绪发生有关,IL-6滴度与其抑郁程度呈正相关,中度异常的彩色脑地形图可较准确判断SLE患者抑郁情绪。

关键词: 系统性红斑狼疮, 焦虑, 抑郁, IL-6, 5-HT

中图分类号:

冷淇, 王晓璐, 苏建玲, 秦勇. 系统性红斑狼疮焦虑抑郁严重程度彩色脑地形图特点与外周血白介素-6和5-羟色胺相关分析[J]. 中华养生保健, 2023, 41(5): 39-43.

参考文献

[1] MORENO-TORRES V, CASTEJÓN R, MARTÍNEZ-URBISTONDO M, et al. Serum cytokines to predict systemic lupus erythematosus clinical and serological activity[J]. Clin Transl Sci, 2022,15(7):1676-1686.
[2] LYNALL M.E.,TURNER L. BHATTI J. et al. Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression[J]. Biol Psychiatry, 2020,88(2):185-196.
[3] HIROHATA S, KIKUCHI H.Role of Serum IL-6 in Neuropsychiatric Systemic lupus Erythematosus. ACR Open Rheumatol[J].2021,3(1):42-49.
[4] CHO T, SATO H, WAKAMATSU A, et al.Mood Disorder in Systemic Lupus Erythematosus Induced by Antiribosomal P Protein Antibodies Associated with Decreased Serum and Brain Tryptophan[J]. The Journal of Immunology, 2021, 206(8):1729-1739.
[5] NAGAI T, ARINUMA Y, YANAGIDA T, et al.Anti-ribosomal P protein antibody in human systemic lupus erythematosus up-regulates the expression of proinflammatory cytokines by human peripheral blood monocytes[J]. Arthritis Rheum,2005,52(3):847-855.
[6] CHAE H S, KANG O H, CHOI J G, et al.5-hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in raw 264.7 cells[J]. Biol. Pharm. Bull,2009,32(4):553-557.
[7] MAFFEI M E.5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology[J]. Int J Mol Sci,2020,22(1):181.
[8] PASOTTI F, SERRANÒ S, AIELLO E N, et al.Assessing mood and cognitive functioning in acute stroke: clinical usability of a Visual Analogue Mood Scale (VAMS)[J]. Neurol Sci,2022,43(3):1741-1745.
[9] KELLER A S, LING R, WILLIAMS L M.Spatial attention impairments are characterized by specific electro-encephalographic correlates and partially mediate the association between early life stress and anxiety[J]. Cogn Affect Behav Neurosci,2022,22(2):414-428.
[10] KOLLER-SCHLAUD K, STRÖHLE A, BÄRWOLF E, et al. EEG Frontal Asymmetry and Theta Power in Unipolar and Bipolar Depression[J]. J Affect Disord 2020,1(276):501-510.
[11] ARINGER M, JOHNSON S R.Systemic Lupus Erythematosus Classification and Diagnosis[J]. Rheum Dis Clin North Am,2021,47(3):501-511.
[12] ZARTALOUDI A, KOUTELEKOS I, POLIKANDRIOTI M, et al.Anxiety and depression in primary care patients suffering of rheumatoid diseases[J]. Psychiatriki,2020,31(2):140-150.
[13] LINDBLOM J, MOHAN C, PARODIS I.Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Literature Review of the Last Decade[J].Brain Sci,2022,12(2):192.
[14] UGUZ F, KUCUK A, CICEK E, et al.Mood, anxiety and personality disorders in patients with systemic lupuserythematosus[J]. Comprehensive Psychiatry,2013,54(4):341-345.
[15] FERNÁNDEZ-PALLEIRO P, RIVERA-BALTANÁS T, RODRIGUES-AMORIM D, et al. Brainwaves Oscillations as a Potential Biomarker for Major Depression Disorder Risk[J]. Clin EEG Neurosci,2020,51(1):3-9.
[16] WIDGE A S, BILGE M T, MONTANA R, et al.Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis[J].Am J Psychiatry,2019,176(1):44-56.
[17] World Health Organization.Depression.2017[EB/OL].(2018-03-22)[2021-09-13]. https://www.who.int/en/news-room/fact-sheets/detail/depression.
[18] STRAC D S, PIVAC N, MUCK-SELER D.The serotonergic system and cognitive function[J].Transl Neurosci,2016,7(1):35-49.
[19] PAUL-SAVOIE E, POTVIN S, DAIGLE K, et al.A deficit in peripheral serotonin levels in major depressive disorder but not in chronic widespread pain[J]. Clin. J. Pain,2011,27:529-534.
[20] KIM Y K, NA K S, SHIN K H, et al.Cytokine imbalance in the pathophysiology of major depressive disorder[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry,2007,31(5):1044-1053.
[21] TING E Y, YANG A C,TSAI S J.Role of Interleukin-6 in Depressive Disorder[J]. Int J Mol Sci.,2020,21(6):2194.
[22] ZHANG J C, YAO W, DONG C, et al.Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut-microbiota-brain axis[J]. Transl Psychiatry,2017, 7(5):e1138.
[23] WANG S, ZHAO X, QIAO Z, et al.Paeoniflorin attenuates depressive behaviors in systemic lupus erythematosus mice[J]. Biomedicine & pharmacotherapy:Biomedecine & pharmacotherapie,2018,103:248-252.
[24] FANGTHAM M, KASTURI S, BANNURU R R, et al.Non-pharmacologic therapies for systemic lupus erythematosus[J]. Lupus,2019, 28(6):703-712.
[25] NAVARRETE-NAVARRETE N, PERALTA-RAMÍREZ M I, SABIO-SÁNCHEZ J M, et al. Efficacy of cognitive behavioural therapy for the treatment of chronic stress in patients with lupus erythematosus: a randomized controlled trial[J]. Psychotherapy & Psychosomatics,2010,79(2):107-115.
[26] BOGDANOVIC G, STOJANOVICH L, DJOKOVIC A, et al.Physical Activity Program Is Helpful for Improving Quality of Life in Patients with Systemic Lupus Erythematosus[J]. Tohoku Journal of Experimental Medicine,2015, 237(3):193.