银杏达莫注射液联合甲磺酸倍他司汀片治疗后循环缺血性眩晕的效果及对血流变指标影响

摘要/Abstract

摘要： 目的探究银杏达莫注射液联合甲磺酸倍他司汀片治疗后循环缺血性眩晕对椎基底动脉供血和血液流变学指标的影响。方法随机选取东昌府人民医院2018年9月—2020年9月收治的80例后循环缺血性眩晕患者进行研究,利用随机数表法分为对照组和试验组,每组40例。对照组采用甲磺酸倍他司汀片治疗,试验组采用银杏达莫注射液联合甲磺酸倍他司汀片治疗,比较两组治疗效果,对比两侧椎体及椎基底血流速度、血液流变学指标、不良反应发生率以及眩晕残障程度。结果试验组治疗总有效率高于对照组（P<0.05）;治疗后,两组左侧椎动脉血流速度、右侧椎动脉血流速度及基底动脉血流速度均大于治疗前（P<0.05）,试验组大于对照组（P<0.05）。治疗后,两组全血高切黏度、全血低切黏度以及血浆黏度和纤维蛋白原均低于治疗前（P<0.05）,试验组低于对照组（P<0.05）。试验组皮疹、恶心呕吐以及头痛头胀等不良反应总发生率与对照组比较,差异无统计学意义（P>0.05）。治疗后,两组眩晕残障评定量表（DHI）躯体性、情绪性以及功能性三个方面评分均低于治疗前（P<0.05）,试验组低于对照组（P<0.05）。结论在后循环缺血性眩晕患者治疗中,银杏达莫注射液联合甲磺酸倍他司汀片治疗效果突出,不良反应少,可有效改善患者椎基底动脉血流速度、血液流变学指标以及眩晕残障程度,值得临床应用。

关键词: 后循环, 缺血, 眩晕, 甲磺酸倍他司汀片, 银杏达莫注射液

Abstract: Objective To explore the effect of Ginkgo Damo Injection combined with Betahistine Mesylate Tablets on vertebrobasilar artery blood supply and blood flow indexes after the treatment of circulating ischemic vertigo. Methods 80 patients with posterior circulation ischemic vertigo who were admitted to Dongchangfu People's Hospital from September 2018 to September 2020 were randomly selected for research, and divided into control group and experimental group by random number table method, with 40 cases in each group. The control group was treated with Betahistine Mesylate Tablets, the experimental group was treated with Ginkgo Damo Injection combined with Betahistine Mesylate Tablets, the therapeutic effect was compared, and the blood flow velocity, hemorheology index, adverse reactions on both sides of the vertebral body and vertebral base rate and degree of vertigo disability were compared. Results The total effective rate of experimental group was higher than that of control group(P<0.05); after treatment, the blood flow velocity of left vertebral artery, right vertebral artery and basilar artery in the two groups were higher than before (P<0.05), and the experimental group was higher than the control group (P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and fibrinogen in two groups were lower than before (P<0.05), and the experimental group was lower than the control group (P<0.05). The total incidence of adverse reactions such as rash, nausea and vomiting, headache and head distension in experimental group had no difference with that in control group (P>0.05). After treatment, somatic, emotionality and functional scores of DHI scale in 2 groups were lower than before (P<0.05), and inter-group comparison of experimental group was lower than control group (P<0.05). Conclusion In the treatment of patients with posterior circulation ischemic vertigo, Ginkgo Damole Injection combined with Betahistine Mesylate Tablets has outstanding therapeutic effect and few adverse reactions, and can effectively improve the vertebrobasilar artery blood flow velocity, hemorheology and vertigo disability degree, it is worth learning.

Key words: posterior circulation, ischemia, dizziness, Betahistine Mesylate Tablets, Ginkgo Damo Injection

中图分类号:

R741

王海涛, 孔艳妮. 银杏达莫注射液联合甲磺酸倍他司汀片治疗后循环缺血性眩晕的效果及对血流变指标影响[J]. 中华养生保健, 2023, 41(3): 48-51.

WANG Hai-tao, KONG Yan-ni. Effect of Circulatory Ischemic Vertigo on Blood Supply and Hemorheology Indexes of Vertebrobasilar Artery after Treatment with Ginkgo Damo Injection and Betahistine Mesylate Tablets for Injection[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(3): 48-51.

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