沉默信息调节因子1对软骨损伤修复机制的研究进展

中华养生保健 ›› 2023, Vol. 41 ›› Issue (3): 1-4.

• 论著 • 下一篇

沉默信息调节因子1对软骨损伤修复机制的研究进展

陈奕孝^1,2,3, 李国庆^2,3, 刘苏^2,3, 翁鉴^2,3, 朱元超^1,2,3, 于斐^2,3, 曾晖^1,2,3,*

1.遵义医科大学研究生院,贵州遵义,563000;
2.北京大学深圳医院骨关节科,广东深圳,518036;
3.骨科生物材料国家地方联合工程研究中心,广东深圳,518036

出版日期:2023-02-01 发布日期:2023-02-06
通讯作者: ^* 曾晖,E-mail：zenghui@pkuszh.com。
作者简介:陈奕孝（1997—）,男,汉族,籍贯：海南省定安县,硕士研究生在读,研究方向：骨关节疾病与骨愈合。
基金资助:
国家自然科学基金（No.82172432、No.82102568、No.82001319）; 骨科生物材料国家地方联合工程研究中心（No.XMHT20190204007）; 深圳市高水平医院建设专项经费资助：高水平“登峰学科建设”项目（No.SZXK023）; 深圳“医疗卫生三名工程”项目（No.SZSM201612092）; 深圳市科技研发资金项目（No.Z2021N054; No.JCYJ20210324110214040）; 广东省基础与应用基础研究基金（No.2021A1515012586）; 白求恩·石药骨质疏松科研基金项目（No.G-X-2020-1107-21）; 北京大学深圳医院科研启动金项目（No.KYQD2021099）

Research Progress on the Mechanism of Silencing Information Regulator 1 on Cartilage Injure Repair

CHEN Yi-xiao^1,2,3, LI Guo-qing^2,3, LIU Su^2,3, WENG Jian^2,3, ZHU Yuan-chao^1,2,3, YU Fei^2,3, ZENG Hui^1,2,3,*

1. Graduate School of Zunyi Medical University, Zunyi Guizhou, 563000, China;
2. Department of bone and joint surgery, Peking University Shenzhen Hospital, Shenzhen Guangdong, 518036, China;
3. National and Local Joint Engineering Research Center of Orthopedic Biomaterials, Shenzhen Guangdong, 518036, China

Online:2023-02-01 Published:2023-02-06

摘要/Abstract

摘要： 软骨容易受到内外界环境影响造成损伤,但因其缺乏神经、血管和淋巴等组织,所以自我修复能力有限,在这一过程中长寿基因沉默信息调节因子1（SIRT1）发挥重要作用。软骨受损后,软骨合成分解代谢紊乱,SIRT1基因可通过影响软骨细胞炎症反应、氧化应激等因素调控软骨损伤进程。在分子机制中,SIRT1基因具有调节软骨稳态的重要作用,其可通过Notch、BMP、Wnt/β-catenin等信号通路对软骨损伤修复进行调节。在本综述中,阐述了SIRT1基因在病理生理条件下对软骨的保护作用及可能的修复机制,为恢复软骨稳态、实现软骨代谢平衡相关研究提供理论支撑。

关键词: 沉默信息调节因子1, 软骨损伤, 信号通路, 发病机制

Abstract: Cartilage is vulnerable to be damaged by internal and external environmental, but its self-repair ability is limited due to the lack of nerves, blood vessels and lymphatic tissues. In this process, longevity gene silencing information regulator 1 (SIRT1) plays an important role. After cartilage damage, cartilage anabolism and catabolism are disordered. SIRT1 gene can regulate the process of cartilage damage by influencing chondrocyte inflammation, oxidative stress and other factors. In the molecular mechanism, SIRT1 gene plays an important role in regulating cartilage homeostasis, which can be mediated by Notch, BMP, Wnt/ β-Catenin and other signal pathways that play a regulatory role in cartilage damage repair. In this review, we illustrate the protective effects of SIRT1 on cartilage under pathophysiological conditions and its possible molecular biological mechanisms, providing theoretical support for research related to restoring cartilage homeostasis and achieving cartilage metabolic balance.

Key words: silencing information regulator 1, cartilage repair, signal pathway, pathogenesis

中图分类号:

R684

陈奕孝, 李国庆, 刘苏, 翁鉴, 朱元超, 于斐, 曾晖. 沉默信息调节因子1对软骨损伤修复机制的研究进展[J]. 中华养生保健, 2023, 41(3): 1-4.

CHEN Yi-xiao, LI Guo-qing, LIU Su, WENG Jian, ZHU Yuan-chao, YU Fei, ZENG Hui. Research Progress on the Mechanism of Silencing Information Regulator 1 on Cartilage Injure Repair[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(3): 1-4.

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沉默信息调节因子1对软骨损伤修复机制的研究进展

Research Progress on the Mechanism of Silencing Information Regulator 1 on Cartilage Injure Repair

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