退黄协定方熏洗联合光疗治疗新生儿黄疸疗效及对NSE、MBP水平的影响

摘要/Abstract

摘要： 目的研究和分析退黄协定方熏洗联合光疗治疗新生儿黄疸疗效及对神经元特异性烯醇化酶（neuron-specific enolase,NSE）和髓鞘碱性蛋白（myelin basic protein,MBP）水平的影响。方法选择2021年10月—2023年3月在沧州市妇幼保健院接受治疗的100例新生儿黄疸患儿作为研究对象,随机对患儿进行编号,奇数设为对照组,偶数设为观察组,每组50例。两组患儿在进行蓝光治疗的基础上,对照组服用茵栀黄口服液治疗,观察组采用退黄协定方熏洗治疗。对治疗前后两组经皮测定胆红素值、每日平均睡眠时间和哭闹次数、治疗前后NSE、MBP水平和治疗后患儿家属满意度进行比较。结果治疗前,两组患儿经皮测定胆红素值比较,差异无统计学意义（P>0.05）;治疗后24 h、48 h、72 h,两组患儿的经皮测定胆红素值均降低,并且治疗后观察组患儿以上指标降低幅度大于对照组,差异有统计学意义（P<0.05）。治疗后,观察组睡眠时间长于对照组,平均哭闹次数低于对照组,差异有统计学意义（P<0.05）。治疗前,两组NSE、MBP水平比较,差异无统计学意义（P>0.05）;治疗后,两组患儿的NSE、MBP水平均降低,并且治疗后观察组NSE、MBP水平明显低于对照组,差异有统计学意义（P<0.05）。治疗后观察组患儿家属的满意度显著高于对照组,差异有统计学意义（P<0.05）。结论退黄协定方熏洗联合光疗治疗新生儿黄疸疗效显著,可提高患儿的睡眠质量,减少哭闹行为,降低NSE、MBP水平。

关键词: 退黄协定方熏洗, 光疗, 新生儿黄疸, NSE, MBP

Abstract: Objective To study and analyze the efficacy of Fumigation and Washing combined with Phototherapy in the treatment of neonatal jaundice and its impact on NSE and MBP levels. Methods A total of 100 children with neonatal jaundice treated in Cangzhou Maternal and Child Health Hospital from October 2021 to March 2023 were selected as the research subjects. The children were randomly numbered, with the odd number set as the control group, and the even number set as the observation group, with 50 cases in each group.On the basis of blue light treatment, the control group took Yinzhihuang oral liquid for treatment, and the observation group received yellow withdrawal protocol for fumigation treatment. Observe and compare the bilirubin values, average daily sleep time and crying times, NSE and MBP levels before and after treatment, and family satisfaction of patients after treatment. Results There was no significant difference in percutaneous bilirubin values between the two groups before treatment (P>0.05), and the percutaneous bilirubin values decreased at 24 h, 48 h and 72 h after treatment, and the observation group decreased more than those in the control group, and the difference was statistically significant (P<0.05); After treatment, the sleep time in the observation group was higher than that in the control group, and the average crying frequency was lower than that in the control group, with a statistically significant difference (P<0.05); Before treatment, there was no statistically significant difference in the levels of NSE and MBP between the two groups (P>0.05). After treatment, the levels of NSE and MBP in both groups decreased, and after treatment, the levels of NSE and MBP in the observation group were significantly lower than those in the control group, with a statistically significant difference (P<0.05); After treatment, The satisfaction of the observation group was significantly higher than that of the control group,statistically significant (P<0.05). Conclusion Fumigation and washing combined with phototherapy have significant therapeutic effects on neonatal jaundice, improving children's sleep quality,reducing crying behavior,and reducing NSE and MBP levels.

Key words: return the yellow agreement party fumigation washing, phototherapy, jaundice of the newborn, NSE, MBP

中图分类号:

R722.17

张文茹. 退黄协定方熏洗联合光疗治疗新生儿黄疸疗效及对NSE、MBP水平的影响[J]. 中华养生保健, 2023, 41(24): 31-34.

ZHANG Wen-ru. Efficacy of Fumigation and Washing Combined with Phototherapy in Treating Neonatal Jaundice and Its Influence on NSE and MBP Levels[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(24): 31-34.

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