瓜蒌皮注射液联合瑞舒伐他汀钙片对冠心病心绞痛患者心肌缺血总负荷、QT离散度的影响

摘要/Abstract

摘要： 目的探讨瓜蒌皮注射液联合瑞舒伐他汀钙片对冠心病心绞痛患者心肌缺血总负荷、QT离散度（QTd）的影响。方法选取2021年1月—2022年12月泰州市中医院收治的140例冠心病心绞痛患者作为研究对象,应用随机数表法进行分组,分为观察组（70例）与对照组（70例）。对照组患者在常规治疗基础上增加瑞舒伐他汀钙片治疗,观察组患者在常规治疗基础上增加瓜蒌皮注射液联合瑞舒伐他汀钙片治疗。对比两组患者治疗后的心绞痛疼痛程度、发作频率、每次持续时间、每日硝酸甘油用量。对比两组患者治疗前后心肌缺血总负荷、QT离散度、QTc离散度（QTcd）以及心功能变化情况。结果观察组心绞痛疼痛评分、发作频率、每次持续时间、每日硝酸甘油用量均明显低于对照组（P<0.05）;治疗后,两组患者心肌缺血总负荷、QTd、QTcd均降低,且观察组低于对照组（P<0.05）;治疗后,两组患者6 min步行距离、左室射血分数（LVEF）均升高,B型利钠肽（BNP）水平均降低,观察组6 min步行距离、LVEF高于对照组,BNP水平低于对照组（P<0.05）。结论瓜蒌皮注射液联合瑞舒伐他汀钙片对冠心病心绞痛患者疗效显著,能够减少患者心绞痛发作次数和频率,减轻疼痛情况,改善患者心肌缺血总负荷和QT离散度,提升心功能,值得临床应用。

关键词: 瓜蒌皮注射液, 瑞舒伐他汀钙片, 冠心病, 心绞痛, 心肌缺血总负荷, QT离散度

Abstract: Objective To investigate the effects of Gualoupi Injection combined with rosuvastatin calcium tablets on total myocardial ischemic load and QT dispersion in patients with coronary heart disease and angina pectoris. Methods A total of 140 patients with coronary heart disease and angina pectoris admitted to our hospital from January 2021 to December 2022 were selected as research subjects. All patients were divided into observation group and control group using random number table method, with 70 patients in each group. Patients in the control group were treated with rosuvastatin calcium tablets on the basis of conventional treatment, while patients in the observation group were treated with Gualoupi Injection and rosuvastatin calcium tablets on the basis of conventional treatment. The degree of angina pain, daily attack frequency, duration of each session, and daily nitroglycerin consumption of patients in the two groups were compared after treatment. The total myocardial ischemic load, QT dispersion, and changes in cardiac function were compared between the two groups before and after treatment. Results The pain score, daily attack frequency, duration of each episode, and daily nitroglycerin dosage in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the total myocardial ischemic load, QTd, and QTcd in both groups decreased, and the observation group was lower than the control group (P<0.05). After treatment, the 6-minute walking distance and LVEF of patients in both groups increased, and the BNP level in the observation group was significantly higher than that in the control group, while the BNP level in the observation group was lower than that in the control group (P<0.05). Conclusion Gualoupi Injection combined with rosuvastatin calcium tablets has a significant therapeutic effect on patients with coronary heart disease and angina pectoris, which can improve the number and frequency of angina pectoris attacks, alleviate pain, improve the total myocardial ischemia load and QT dispersion in patients, and enhance cardiac function. It is worthy of clinical application and promotion.

Key words: Gualoupi injection, rosuvastatin calcium tablets, coronary heart disease, angina pectoris, total load of myocardial ischemia, QTd

中图分类号:

R541.4

夏阳. 瓜蒌皮注射液联合瑞舒伐他汀钙片对冠心病心绞痛患者心肌缺血总负荷、QT离散度的影响[J]. 中华养生保健, 2023, 41(22): 34-37.

XIA Yang. Effects of Gualoupi Injection and Rosuvastatin Calcium Tablets on Total Ischemia Load and QT Dispersion in Patients with Coronary Heart Disease and Angina Pectoris[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(22): 34-37.

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