自贡地区健康体检中老年人群阿尔茨海默病患病调查及AD7C-NTP的相关性分析

摘要/Abstract

摘要： 目的探讨自贡地区健康体检中老年人群阿尔茨海默病患病调查及AD7C-NTP的相关性。方法选取2021年1月—2022年6月在自贡市第一人民医院进行健康体检的1 460人为研究对象,除进行常规体检外,同时进行阿尔茨海默病相关神经丝蛋白（AD7c-NTP) 检测。根据AD7c-NTP结果,最后筛选出尿AD7C-NTP异常升高的受试者,分为AD7C-NTP正常组（n=1 250）和AD7C-NTP升高组（n=210）,收集两组血液生化指标数据进行对比,同时对高AD7c-NTP人群通过简易智力状态检查（MMSE）以及MRI进行中阿尔茨海默病筛查,并根据临床痴呆评定量表(CDR),分析不同程度AD其AD7C-NTP水平的差异性。结果 1 460名体检者中尿液AD7c-NTP异常升高达210人,占比14.38%。AD7c-NTP异常升高人群与正常人群血清Cr、TBIL、GLU、TC、LDL比较,差异均有统计学意义（P<0.05）;在210例高AD7C-NTP水平人群中AD确诊为152例（72.38%）,不同认知功能障碍的AD患者其AD7C-NTP水平比较,差异有统计学意义（P<0.05）;AD7c-NTP水平与Cr、GLU、TC、LDL存在正相关性（P<0.05）,与MMSE呈负相关,与TBIL无明显相关（P>0.05）。结论 AD7c-NTP水平与认知功能存在相关性,可以作为早期筛查AD的辅助方法之一;AD7c-NTP水平与Cr、GLU、TC、LDL存在相关性,高Cr、GLU、TC、LDL是AD发病的危险因素之一。

关键词: 自贡地区, 健康体检, 阿尔茨海默病, 调查, AD7C-NTP, 相关性

Abstract: Objective To investigate the prevalence of Alzheimer's disease and the correlation between AD7C-NTP in middle-aged and elderly people undergoing physical examination in Zigong area. Methods From January 2021 to June 2022, 1 460 subjects were selected to undergo physical examinations in the Health Management Department of the First People's Hospital of Zigong City. In addition to routine physical examination, 1 460 patients were also tested for Alzheimer's disease related neurofilament protein AD7c-NTP. Based on the results of AD7c-NTP, subjects with abnormally elevated urinary AD7C-NTP were selected and divided into normal AD7C-NTP group (n=1 250) and AD7C-NTP-elevated group (n=210). Blood biochemical index data were collected and compared between the two groups. At the same time, people with high AD7c-NTP were screened for Alzheimer's disease through simple mental state examination (MMSE) and MRI, and according to the Clinical Dementia Rating Scale (CDR). Analyze the differences in AD7C-NTP levels in different degrees of AD. Results Among the 1 460 examinees, there were 210 cases with abnormal increase in urine AD7c-NTP, accounting for 14.38%. There were differences in serum Cr, TBIL, GLU, TC, and LDL between individuals with abnormal AD7c-NTP elevation and normal individuals (P<0.05); Among the 210 individuals with high AD7C-NTP levels, 152 (72.38%) were diagnosed with AD, and there were differences in AD7C-NTP levels among AD patients with different cognitive impairments (P<0.05); The level of AD7c-NTP is positively correlated with Cr, GLU, TC, and LDL (P<0.05), negatively correlated with MMSE, and not significantly correlated with TBIL (P>0.05). Conclusion There is a correlation between AD7c-NTP levels and cognitive function, which can be used as one of the auxiliary methods for early screening of AD; The level of AD7c-NTP is correlated with Cr, GLU, TC, and LDL, and high Cr, GLU, TC, and LDL are one of the risk factors for the onset of AD.

Key words: Zigong region, physical examination, Alzheimer's disease;, investigation, AD7C-NTP, relevance

中图分类号:

R749.16

郑戈, 毕兵, 朱晶, 郭久畅. 自贡地区健康体检中老年人群阿尔茨海默病患病调查及AD7C-NTP的相关性分析[J]. 中华养生保健, 2023, 41(20): 90-93.

Zheng Ge, Bi Bing, Zhu Jing, Guo Jiu-chang. Investigation on the prevalence of Alzheimer's Disease and Correlation Analysis of AD7C-NTP in Middle-Aged and Elderly People Undergoing Physical Examination in Zigong Area[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(20): 90-93.

参考文献

[1] JACK C R JR, ALBERT M S, KNOPMAN D S, et al. Introduction to the recommendations from the National Institute on Aging - Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimer's Dement,2011,7(3):257-262.
[2] KUKULL W A, BOWEN J D.Dementia epidemiology[J]. Med Clin North Am,2002,86(3):573-590.
[3] JUNG Y J, KIM Y H, BHALLA M, et al.Genomics: new light on alzheimer's disease research[J]. Int J Mol Sci,2018,19(12):3771.
[4] 王英全,梁景宏,贾瑞霞,等.2020-2050年中国阿尔茨海默病患病情况预测研究[J].阿尔茨海默病及相关病,2019,2(1):289-298.
[5] 史奇,朱丽萍,颜玮,等.江西省60岁及以上居民老年痴呆症和记忆力减退流行病学调查[J].实用临床医学,2018,19(1):83-87.
[6] 贾建平,陈生弟.神经病学[M].北京:人民卫生出版社,2013:218.
[7] HEBERT L E, WEUVE J, SCHERR P A, et al.Alzheimer disease in the United States (2010-2050) estimated using the 2010 census[J]. Neurology,2013,80:1778-1783.
[8] 周丽华,徐武华,王玉周,等.尿AD7C-NTP检测对轻度认知功能障碍诊断价值的Meta分析[J].实用老年医学,2019,33(5):497-500.
[9] 管成果,和巾杰,王婧.痴呆症综合认知功能评估工具的研究进展[J/OL].护士进修杂志,2023,38(12):1092-1096.
[10] 金贺,王蓉.阿尔茨海默病相关神经丝蛋白(AD7c-NTP)的研究现状概述[J].老年医学与保健,2019,25(3):411-414.
[11] 朱瑞,袁欣瑞,彭丹涛.阿尔茨海默病患者尿液中相关神经丝蛋白含量的诊断价值[J].中华老年医学杂志,2012,31(7):575-577.
[12] 刘彬,毕鸿艳,张凌峰,等.老年人群中AD7c-NTP检测的意义[J].中国老年保健医学,2017,15(5):30-31.
[13] 李红艳,余先锋,盛灿,等.老年糖尿病伴认知功能下降患者尿AD7c-NTP水平与认知功能的关系[J].医学研究生学报,2022,35(12):1283-1287.
[14] 方堃,张玉蓉,王芳,等.尿AD7c-NTP联合尿甲醛、血清S100B在AD早期诊断中的价值及与认知水平的相关性[J].实用医学杂志,2019,35(1):113-116,121.
[15] 李爱东,陈曦,陈建良,等.不同类型认知障碍患者的尿液AD7c-NTP与头部MRI、MRS的相关性研究[J].国际精神病学杂志,2017,44(4):643-645,657.
[16] 中国痴呆与认知障碍写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会.2018中国痴呆与认知障碍诊治指南(七):阿尔茨海默病的危险因素及其干预[J].中华医学杂志,2018,98(13):971-977.
[17] 叶子园,郭熙,郭守霞,等.阿尔茨海默病相关危险因素的研究进展[J].吉林医药学院学报,2023,44(1):52-54.
[18] 徐勇,林璐,谭琪,等.阿尔茨海默病的预防理论与干预策略(NEWSTART)[J].阿尔茨海默病及相关病杂志,2021,4(3):242-244,252.
[19] 张玉蓉,方堃,张任飞,等.绵阳市中老年人群尿液阿尔茨海默病相关神经丝蛋白水平及相关因素[J].四川精神卫生,2023,36(1):53-58.
[20] 庞敬涛,刘娟,孙丽,等.痰浊蒙窍型轻度认知功能障碍(MCI)的认知损害特点及血清Hcy、GHb、尿AD7c-NTP表达水平相关性研究[J].实用中医内科杂志,2022,36(9):123-125.