冠心病不稳定型心绞痛中医证型与纤维蛋白原、凝血酶原时间、凝血活酶时间的相关性分析

摘要/Abstract

摘要： 目的探讨冠心病不稳定性心绞痛（UA）患者的临床中医证型与凝血相关指标及冠状动脉狭窄程度的相关性。方法将2018年2月—2020年2月无锡市第二中医医院收治的120例冠心病患者纳入研究,测定纤维蛋白原（FIB）水平、凝血酶原时间（PT）、凝血活酶时间（TT）、CT-1、hs-CRP、Lp-PLA2值,计算eGRF值,分析中医证型与其相关性。结果各证型中FIB的组内比较,差异有统计学意义（P<0.05）,心血瘀阻证患者FIB水平显著高于其他三种证型,痰瘀互结证患者FIB水平显著低于其他三种证型。各证型的PT、TT指标比较,差异无统计学意义（P>0.05）。各证型的CT-1、hs-CRP、Lp-PLA2、eGRF与对照组比较,差异有统计学意义（P<0.05）,气虚血瘀证和痰瘀互结证患者CT-1及hs-CRP值均明显高于心血瘀阻证和气阴两虚证患者,痰瘀互结证和心血瘀阻证患者的Lp-PLA2及eGRF值均明显高于气虚血瘀证气阴两虚证患者。不同程度的冠状动脉狭窄患者的CT-1、hs-CRP、Lp-PLA2、eGRF与对照组组间比较,差异有统计学意义（P<0.05）。结论 120例冠心病不稳定型心绞痛患者中,气虚血瘀证>痰瘀互结证>气阴两虚证>心血瘀阻证,心血瘀阻证纤维蛋白原（FIB）值显著高于其他证型。患者CT-1、hs-CRP、Lp-PLA2、eGRF水平与不稳定型心绞痛中医证型之间存在密切关系,通过其表达水平可以了解冠状动脉病变程度,为临床治疗提供相应的依据,能在早期防冠心病方面发挥作用。

关键词: 冠心病, 中医证型, 凝血功能, 相关性分析

Abstract: Objective The study was to investigate the correlation between the clinical syndromes of traditional Chinese medicine and coagulation indexes and the degree of coronary artery stenosis in patients with unstable angina pectoris (UA). Methods 120 patients admited to Wuxi Second Traditional Chinese Medicine Hospital from February 2018 to February 2020 were included in the study. Fibrinogen (FIB) level, prothrombin time (PT), thrombin time (TT), CT-1, hs-CRP and Lp-PLA2 values were determined, and eGRF values were calculated to analyze the correlation between TCM syndrome types and their correlation. Results The difference of FIB in each syndrome type was statistically significant (P<0.05). FIB level of patients with Blood stasis syndrome was significantly higher than that of the other three syndromes, and FIB level of patients with phlegm-stasis syndrome was significantly lower than that of the other three syndromes. There was no statistically significant difference in PT and TT among all syndromes（P>0.05）. There were significant statistical differences between CT-1, hs-CRP, Lp-PLA2 and eGRF of each syndrome type and the control group（P<0.05）.The CT-1 and hs CRP values of patients with Qi deficiency and blood stasis syndrome and phlegm stasis syndrome are significantly higher than those of patients with heart blood stasis obstruction syndrome and Qi yin deficiency syndrome. The Lp-PLA2 and eGRF values of patients with phlegm stasis syndrome and heart blood stasis syndrome are significantly higher than those of patients with qi deficiency and blood stasis syndrome. There were statistically significant differences in CT-1, hs CRP, Lp PLA2, and eGRF between patients with different degrees of coronary artery stenosis and the control group (P<0.05). Conclusion In 120 patients, the syndrome of qi deficiency and blood stasis > Mutual accumulation of phlegm and blood stasis > Deficiency of qi and Yin. The fibrinogen (FIB) value of the syndrome was significantly higher than that of other syndrome types. The levels of CT-1, hs-CRP, Lp-PLA2 and eGRF are closely related to the TCM syndrome type of unstable angina pectoris in patients. The expression level can help to understand the degree of coronary artery disease, provide the corresponding basis for clinical treatment, and play a role in the early prevention and treatment of coronary heart disease.

Key words: coronary heart disease, TCM syndrome type, coagulation function, correlation analysis

中图分类号:

R543.3

戚猛, 周莹, 缪娜, 缪佳铭. 冠心病不稳定型心绞痛中医证型与纤维蛋白原、凝血酶原时间、凝血活酶时间的相关性分析[J]. 中华养生保健, 2023, 41(20): 17-21.

QI Meng, ZHOU Ying, MIAO Na, MIAO Jia-ming. Relationship between Traditional Chinese Medicine Syndrome Types of Unstable Angina Pectoris of Coronary Heart Disease and Fibrinogen, Prothrombin Time Correlation Analysis of Thrombin Time[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(20): 17-21.

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