支气管镜肺泡灌洗结合吸入用乙酰半胱氨酸溶液对重症肺炎患者临床效果观察

中华养生保健 ›› 2023, Vol. 41 ›› Issue (19): 8-11.

支气管镜肺泡灌洗结合吸入用乙酰半胱氨酸溶液对重症肺炎患者临床效果观察

孙凤娇¹, 马卫武^2,*

1.平原县第一人民医院重症医学科,山东德州,253100;
2.青岛市第三人民医院心内科,山东青岛,266000

出版日期:2023-10-01 发布日期:2023-09-20
通讯作者: ^*马卫武,E-mail：maweiwu8721@163.com。
作者简介:孙凤娇（1988—）,女,汉族,籍贯：山东省德州市,硕士研究生,主治医师,研究方向：重症疾病诊治。
基金资助:
山东省医药卫生科技发展计划项目（2018WS389）

Clinical Observation of Bronchoscopic Alveolar Lavage Combined with Inhalation of Acetylcysteine Solution in Patients with Severe Pneumonia

SUN Feng-jiao¹, MA Wei-wu^2,*

1. Department of Critical Medicine, First People's Hospital of Pingyuan County, Dezhou Shandong 253100, China;
2. Department of Cardiology, Qingdao Third People's Hospital, Qingdao Shandong 266000, China

Online:2023-10-01 Published:2023-09-20

摘要/Abstract

摘要： 目的探讨对重症肺炎患者采用支气管镜肺泡灌洗结合吸入用乙酰半胱氨酸溶液治疗对血气指标与肺通气功能的影响。方法选择2021年1月—2021年12月平原县第一人民医院收治的重症肺炎患者80例,以随机数表法分为对照组和观察组,每组40例。对照组采用支气管镜进行肺泡灌洗,观察组采用支气管镜联合吸入用乙酰半胱氨酸溶液干预,比较两组总有效率以及临床指标。结果观察组治疗总有效率高于对照组,差异有统计学意义（P<0.05）。治疗后,观察组氧分压、第1秒用力呼气量（FEV₁）、一秒率（FEV₁/FVC）、呼气峰值流量（PEF）水平高于对照组,二氧化碳分压低于对照组,差异有统计学意义（P<0.05）。治疗后,观察组降钙素原（PCT）、白介素（IL）-6水平均低于对照组,IL-10水平高于对照组,差异有统计学意义（P<0.05）。两组支气管镜治疗期间均未发生副损伤。结论重症肺炎患者予支气管镜肺泡灌洗结合吸入用乙酰半胱氨酸溶液治疗效果确切,可减轻机体炎症反应。

关键词: 重症肺炎, 支气管镜, 肺泡灌洗, 肺通气功能

Abstract: Objective To investigate the effects of bronchoscopic alveolar lavage combined with inhalation of acetylcysteine solution on blood gas indexes and pulmonary ventilation function in patients with severe pneumonia. Methods 80 patients with severe pneumonia admitted to First People's Hospital of Pingyuan County from January to December 2021 were selected and randomly divided into groups. The control group (n=40) received bronchoscopic alveolar lavage, while the other (n=40) received inhalation of acetylcysteine solution for intervention. The total effective rate and clinical indicators of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the others, with a statistically significant difference (P<0.05). After treatment, the partial pressure of oxygen in the observation group was higher than those, and the partial pressure of carbon dioxide was lower than the others. The levels of FEV₁, FEV₁/FVC, and PEF in the first second were significantly higher than those in the others (P<0.05). After treatment, the PCT and interleukin IL-6 in the observation group were lower on average than those in the control group, and the levels of IL-10 were higher than those in the control group, with a statistically significant difference (P<0.05). Conclusion The treatment of severe pneumonia patients with bronchoscopic alveolar lavage combined with inhalation of acetylcysteine solution has a definite effect, and can alleviate the body's inflammatory reaction.

Key words: severe pneumonia, bronchoscope, alveolar lavage, pulmonary ventilation function

中图分类号:

R563.1

孙凤娇, 马卫武. 支气管镜肺泡灌洗结合吸入用乙酰半胱氨酸溶液对重症肺炎患者临床效果观察[J]. 中华养生保健, 2023, 41(19): 8-11.

SUN Feng-jiao, MA Wei-wu. Clinical Observation of Bronchoscopic Alveolar Lavage Combined with Inhalation of Acetylcysteine Solution in Patients with Severe Pneumonia[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(19): 8-11.

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