酪酸梭活菌胶囊联合复方谷氨酰胺肠溶胶囊对溃疡性结肠炎患者的疗效分析

摘要/Abstract

摘要： 目的研究酪酸梭活菌胶囊联合复方谷氨酰胺肠溶胶囊对溃疡性结肠炎患者的疗效。方法选取2019年1月—2021年12月聊城市东昌府人民医院收治的120例溃疡性结肠炎患者,用抽签法分为对照组和观察组,每组60例。对照组患者服用酪酸梭活菌胶囊,观察组患者在对照组基础上加用复方谷氨酰胺肠溶胶囊。比较两组疗效、血清肿瘤坏死因子-α（TNF-α）、白细胞介素-2（IL-2）、超敏C-反应蛋白（hs-CRP）、IL-6、肠屏障功能指标（D-乳酸、二胺氧化酶和细菌内毒素）水平和脓血便、腹痛、黏膜病变腹泻症状评分。结果观察组的有效率明显高于对照组（P<0.05）。治疗前,两组患者的血清TNF-α、IL-2、hs-CRP和IL-6水平差异无统计学意义（P>0.05）;治疗后,两组患者的血清TNF-α、IL-2、hs-CRP和IL-6水平均明显降低（P<0.05）,且观察组患者的血清TNF-α、IL-2、hs-CRP和IL-6水平明显低于对照组（P<0.05）。治疗前,两组患者的D-乳酸、二胺氧化酶和细菌内毒素水平差异无统计学意义（P>0.05）;治疗后,两组患者的D-乳酸、二胺氧化酶和细菌内毒素水平均明显降低（P<0.05）,且观察组患者的D-乳酸、二胺氧化酶和细菌内毒素水平明显低于对照组（P<0.05）。治疗前,两组患者的脓血便、腹痛、黏膜病变和腹泻症状评分差异无统计学意义（P>0.05）;治疗后,两组患者的脓血便、腹痛、黏膜病变和腹泻症状评分均明显降低（P<0.05）,且观察组的脓血便、腹痛、黏膜病变和腹泻评分明显低于对照组（P<0.05）。结论酪酸梭活菌胶囊联用复方谷氨酰胺肠溶胶囊对溃疡性结肠炎患者有显著的疗效,能明显减轻炎症反应,改善肠屏障功能,减轻症状。

关键词: 酪酸梭活菌胶囊, 复方谷氨酰胺肠溶胶囊, 溃疡性结肠炎

Abstract: Objective To investigate the effect of clostridium butyricum capsule combined with compound glutamine enteric coated capsule on patients with ulcerative colitis. Methods A total of 120 patients with ulcerative colitis admitted to Dongchangfu People's Hospital of Liaocheng city from January 2019 to December 2021 was selected. The lottery method was divided into two groups. The control group was given Clostridium butyricum capsules, and the observation group was given compound glutamine enteric coated capsules. To compare the efficacy of the two groups, the serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), hypersensitive C-reactive protein (hs-CRP), IL-6, intestinal barrier function (D-lactic acid, diamine oxidase, and bacterial endotoxin), and stool, abdominal pain, mucosal diarrhea were scores. Results The effective rate of the observation group was significantly higher than control group(P<0.05). Before treatment, there was no significant difference in the levels of TNF-α, IL-2, hs-CRP and IL-6(P>0.05). After treatment, serum TNF-α, IL-2, hs-CRP and IL-6 decreased significantly(P<0.05), and serum TNF -α, IL-2, hs-CRP and IL-6 in the observation group were significantly lower(P<0.05). Before treatment, the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the two groups had no significant difference(P>0.05). After treatment, the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the two groups were significantly reduced(P<0.05), and the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the observation group were significantly lower than those in the control group(P<0.05). Before treatment, there was no significant difference in the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea symptoms between the two groups(P>0.05). After treatment, the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea symptoms in the two groups were significantly reduced(P<0.05), and the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Clostridium butyricum capsule combined with compound glutamine enteric-coated capsule has significant efficacy in patients with ulcerative colitis,

中图分类号:

R574.62

高向君, 王淑平. 酪酸梭活菌胶囊联合复方谷氨酰胺肠溶胶囊对溃疡性结肠炎患者的疗效分析[J]. 中华养生保健, 2023, 41(19): 173-176.

GAO Xiang-jun, WANG Shu-ping. Analysis of Therapeutic Effect of Clostridium Butyricum Capsule Combined with Compound Glutamine Enteric Coated Capsule on Patients with Ulcerative Colitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(19): 173-176.

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