血府逐瘀汤联合双联抗血小板治疗大动脉粥样硬化性脑梗死的疗效分析

摘要/Abstract

摘要： 目的探讨血府逐瘀汤联合双联抗血小板治疗大动脉粥样硬化性脑梗死的临床疗效。方法选取2020年2月—2022年2月在湖北荆门市钟祥长安医院就诊的176例大动脉粥样硬化性脑梗死患者,随机数表法分为观察组（血府逐瘀汤联合双联抗血小板,n=88）和对照组（双联抗血小板,n=88）。对比两组患者临床疗效、神经功能缺损情况、预后情况、血液流变学指标、血清和肽素（CPP）、N末端B型尿钠肽（NT-proBNP）水平和药物不良反应。结果观察组总有效率显著高于对照组,差异有统计学意义（P<0.05）。治疗后两组患者改良爱丁堡-斯堪的纳维亚（MESSS）评分和改良Rankin量表（mRS）评分与治疗前比较,均显著降低（P<0.05）,且观察组MESSS评分和mRS评分均显著低于对照组,差异有统计学意义（P<0.05）。治疗后21 d两组患者全血黏度、血浆黏度和红细胞压积与治疗前比较,均显著降低（P<0.05）,且观察组改善更为显著,差异有统计学意义（P<0.05）。治疗前两组NT-proBNP、CPP比较,差异无统计学意义（P>0.05）。治疗后两组NT-proBNP、CPP与治疗前比较,均显著降低（P<0.05）,且观察组NT-proBNP、CPP均显著低于对照组,差异有统计学意义（P<0.05）。两组患者治疗期间均未出现严重不良反应。结论血府逐瘀汤联合双联抗血小板治疗大动脉粥样硬化性脑梗死效果显著,可有效改善患者预后,减轻脑损伤,安全性良好,值得临床应用。

关键词: 脑梗死, 大动脉粥样硬化, 血府逐瘀汤, 双联抗血小板

Abstract: Objective To investigate the clinical effect of Xuefu Zhuyu Decoction combined with double antiplatelet on Atherosclerotic Cerebral Infarction. Methods 176 patients with atherosclerotic cerebral infarction in Zhongxiang Changan Hospital, Jingmen City, Hubei Province from February 2020 to February 2022 were divided into observation group (Xuefu Zhuyu Decoction combined with double antiplatelet, n=88) and control group (double antiplatelet, n=88). The clinical efficacy, neurological deficit, prognosis, hematological indicators, serum and peptidysin (CPP), N-terminal type B urinary sodium peptide (NT-proBNP) levels, and adverse drug reactions were compared. Results The total response rate of the observation group was significantly higher than the control group (P<0.05). After treatment, the modified Edinburgh-Scandinavian (MESSS) and modified Rankin scale (mRS) scores of the two groups were significantly lower than those before treatment (P<0.05), and the MESSS and mRS scores in the observation group were significantly lower than those in the control group (P<0.05). At 21 d after treatment, the whole blood viscosity, plasma viscosity, and hematocrit were significantly lower than before treatment (P<0.05), moreover, the improvement in the observation group was more significant (P<0.05). There was no significant difference in NT-proBNP and CPP between the two groups before treatment (P>0.05). NT-proBNP and CPP in the two groups after treatment were significantly lower than those before treatment (P<0.05), and NT-proBNP and CPP in the observation group were significantly lower than those in the control group (P<0.05). Neither group had any serious adverse effects during treatment. Conclusion Xuefu Zhuyu Decoction combined with dual antiplatelet agents has significant effect on atherosclerotic cerebral infarction, and can effectively improve the prognosis of patients, reduce brain injury, with good safety and is worthy of clinical application.

Key words: cerebral infarction, atherosclerosis, Xuefu Zhuyu Decoction, double antiplatelet

中图分类号:

R743

尹涛. 血府逐瘀汤联合双联抗血小板治疗大动脉粥样硬化性脑梗死的疗效分析[J]. 中华养生保健, 2023, 41(18): 16-19.

YIN Tao. Analysis of the Effect of Xuefu Zhuyu Decoction Combined with Double Antiplatelet on Atherosclerotic Cerebral Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(18): 16-19.

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