输尿管镜钬激光碎石取石术对输尿管结石患者肾功能、血清炎性因子水平的影响

摘要/Abstract

摘要： 目的分析输尿管镜钬激光碎石取石术对输尿管结石患者肾功能与血清炎性因子水平的影响。方法选择2020年10月—2022年8月平原县第一人民医院收治的92例输尿管结石患者作为研究对象,根据治疗方法的不同分为两组,分别为观察组和对照组,每组46例。观察组治疗方案为输尿管镜钬激光碎石取石术,对照组治疗方案为传统开放手术。观察两组患者的肾功能与血清炎性因子水平变化情况。结果观察组患者的手术时间、术中出血量与住院时间均优于对照组,患者治疗后的各项血清炎性因子指标水平与并发症总发生率均低于对照组,差异有统计学意义（P<0.05）;两组患者在肾功能指标与治疗有效率上差异无统计学意义（P>0.05）。结论输尿管镜钬激光碎石取石术有利于改善输尿管结石手术进程,具有良好的改善肾功能与疗效表现,且对患者机体血清炎性因子水平的影响较小,为患者的康复效果提供可靠保障。

关键词: 输尿管镜, 钬激光碎石取石术, 输尿管结石, 肾功能, 血清炎性因子

Abstract: Objective To analyze the effects of holmium laser lithotripsy on renal function and serum inflammatory factor levels in patients with ureteral stones. Methods From October 2020 to August 2022, 92 patients with ureteral calculi were enrolled from the First People's Hospital of Pingyuan County. According to different treatment methods, the patients were divided into two groups, 46 cases in each group. The observation group was treated with ureteroscopic holmium laser lithotripsy, while the control group was treated with traditional open operation. The changes of renal function and serum inflammatory factors in two groups were observed. Results Patients in the observation group showed better operative time, intraoperative bleeding and hospitalization time than those in the control group, and the levels of serum inflammatory factors and the overall incidence of complications after treatment were lower than those in the control group (P<0.05). Conclusion Holmium laser lithotripsy with ureteroscopy is beneficial to improve the process of ureteral stone surgery, with good renal function improvement and efficacy performance, and has less impact on the level of serum inflammatory factors in patients' organism, providing a reliable guarantee for patients' rehabilitation results.

Key words: ureteroscopy, holmium laser lithotripsy, ureteral stones, renal function, serum inflammatory factor

中图分类号:

纪洪博. 输尿管镜钬激光碎石取石术对输尿管结石患者肾功能、血清炎性因子水平的影响[J]. 中华养生保健, 2023, 41(18): 12-15.

JI Hong-bo. Effect of Ureteroscopic Holmium Laser Lithotripsy on Renal Function and Serum Inflammatory Factor Levels in Patients with Ureteral Calculi[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(18): 12-15.

参考文献

[1] 刘庆辉,张志超,姚丽,等.软性输尿管镜钬激光碎石术治疗单侧上尿路结石的疗效及对外周血T淋巴细胞亚群、肾功能和氧化应激因子的影响[J].国际泌尿系统杂志,2021,41(1):1-5.
[2] 葛长龙,刘毅,刘闯.标准通道经皮肾镜取石术联合输尿管软镜钬激光碎石术对上尿路结石患者的结石清除率、肾功能指标及血流动力学的影响[J].国际泌尿系统杂志,2020,40(5):769-772.
[3] 王裕中,张志超,李宏军,等.输尿管镜钬激光碎石术治疗输尿管上段嵌顿性结石的效果及对肾功能、术后疼痛的影响[J].临床误诊误治,2020,33(4):77-81.
[4] 唐炯,吴明震.输尿管镜下钬激光碎石术和气压弹道碎石术治疗老年输尿管结石的疗效及对患者肾功能的影响研究[J].贵州医药,2021,45(8):1251-1252.
[5] 周善昌,兰建江,韦银霞,等.经皮肾通道输尿管镜钬激光碎石术与气压弹道碎石术治疗复杂性肾结石的疗效比较[J].国际泌尿系统杂志,2022,42(4):636-639.
[6] 兰海河,夏勇,邵林海,等.输尿管软镜钬激光碎石术联合微通道经皮肾镜取石术对上尿路结石患者的治疗效果分析[J].中国药物与临床,2021,21(16):2809-2811.
[7] 宁勇. 输尿管镜下钬激光碎石手术治疗输尿管结石的效果及对患者不良反应的影响[J].检验医学与临床,2020,17(2):251-253.
[8] 胡世成,管玉彬,虞昌文.经输尿管镜气压弹道碎石和钬激光碎石对输尿管结石患者疗效、围术期指标和并发症的影响[J].湖南师范大学学报:医学版,2021,18(6):192-195.
[9] 秦刚,谢英金.输尿管软镜下钬激光碎石术对复杂性上尿路结石患者疗效及术后复发的影响[J].实用医院临床杂志,2021,18(5):166-169.
[10] 庞国福,袁小旭,叶啸.输尿管硬镜联合瑞邦阻石网篮钬激光碎石术治疗输尿管上段结石疗效及对患者肾功能,氧化应激的影响[J].湖南师范大学学报:医学版,2021,18(5):30-33.
[11] 梁柯,柯尊金,金刚,等.简单输尿管结石钬激光碎石术后留置输尿管导管与双J管的对比研究[J].中国内镜杂志,2020,26(9):55-59.
[12] 孟凯,李东.钬激光碎石术治疗输尿管结石后发生输尿管狭窄的危险因素分析[J].贵州医药,2020,44(9):1440-1441.
[13] 郭营利,俞健,沈俊文.输尿管软镜钬激光碎石术治疗输尿管结石伴肾积水的有效性及安全性分析[J].中华全科医学,2023,21(3):420-422,462.
[14] 刘彦军,景治安,毛长青,等.软性与硬性输尿管镜钬激光碎石术治疗输尿管结石伴输尿管狭窄疗效比较[J].新乡医学院学报,2020,37(10):976-979.
[15] 裴志圣,杨云波,刘桂迁,等.输尿管软镜钬激光碎石术和经皮肾镜碎石术对上尿路结石患者肾功能及炎症因子的影响[J].中华保健医学杂志,2022,24(3):189-191.
[16] 张中兴,张延兵,张晓路.输尿管硬镜联合钬激光碎石术治疗不同直径输尿管结石临床效果对比[J].中国临床医生杂志,2022,50(9):1088-1090.