SLC6A11基因多态性与耐药性癫痫之间的关联性的Meta分析

中华养生保健 ›› 2023, Vol. 41 ›› Issue (17): 55-60.

SLC6A11基因多态性与耐药性癫痫之间的关联性的Meta分析

赵明洋^1,2, 胡雪梅^1,2, 王东森^1,2, 吴庆建^2,*

1.济宁医学院临床医学院,山东济宁,272100;
2.济宁市第一人民医院急诊内科,山东济宁,272011

出版日期:2023-09-01 发布日期:2023-08-30
通讯作者: ^*吴庆建,E-mail：wqw110@163.com。
作者简介:赵明洋（1998—）,女,汉族,籍贯：山东省临沂市,硕士研究生,住院医师,研究方向：老年心脑血管疾病。
基金资助:
济宁市重点研发项目（编号：2020YXNS035）; 山东省自然科学基金面上项目（编号：ZR2021MH133）

Meta-Analysis of Associations between Polymorphisms of SLC6A11 Genes and Drug-Resistant Epilepsy

ZHAO Ming-yang^1,2, HU Xue-mei^1,2, WANG Dong-sen^1,2, WU Qing-jian^2,*

1. School of Clinical Medicine, Jining Medical College, Jining Shandong 272100, China;
2. Department of Emergency Internal Medicine, Jining First People's Hospital, Jining Shandong 272100, China

Online:2023-09-01 Published:2023-08-30

摘要/Abstract

摘要： 目的运用Meta分析探寻SLC6A11基因rs2272394、rs2272395和rs2272400多态性是否与成人耐药性癫痫患者的耐药性密切相关。方法制订文献检索方案,通过检索Pubmed、Embase、Cochrane图书馆、Web of Science数据库、中国知网、万方数据知识服务平台和维普资讯中文期刊服务平台检索数据库搜索有关SLC6A11基因多态性与耐药性癫痫治疗相关的中外文献,由两人共同筛选文献,提取数据并进行交叉核对,对纳入的文献进行质量评价后,将符合标准的文献纳入,使用R4.2.1软件对文献进行Meta分析,同时采用基因模型进行分析。结果 4篇文献中的9项研究被纳入,其中耐药组病例共有1 172例,药物敏感组病例共有1 340例。其中等位基因C与T采用固定效应模型得出OR=0.89,95%CI=0.79~1.01;剔除一篇边缘性研究后,结果示OR=0.93,95%CI=0.82~1.06;隐性基因模型CC/TC+TT的OR=0.79,95%CI=0.67~0.92;显性基因模型TT/TC+CC的OR=0.99,95%CI=0.80~1.23;加性基因模型CC/TT的OR=0.86,95%CI=0.63~1.16;超显性基因模型TT+CC/TC的OR=0.83,95%CI=0.72~0.97。结论目前暂无明确证据证明SLC6A11基因的rs2272394、rs2272395和rs2272400多态性与耐药性癫痫有关。

关键词: 耐药性癫痫, SLC6A11, 癫痫, 基因多态性

Abstract: Objective To investigate the association between rs2272394, rs2272395 and rs2272400 polymorphisms of SLC6A11 gene and drug-resistant epilepsy. Methods Formulate a literature search plan, and search the Chinese and foreign literature related toSLC6A11 gene polymorphisms. PubMed, Embase, Cochrane Library, Web of Science, China []National Knowledge Infrastructure, Wan-fang Data Knowledge Service Platform, and China Science and Technology Journal Database were searched for relevant studies. The two people jointly screened the literature, extracted the data and cross-checked, and after evaluating the quality of the included literature, the literature that met the criteria was included. Meta-analysis of the literature using R4.2.1 software was performed and a genetic model was used for analysis. ResultNine studies from four studies were included, with a total of 1 172 cases in the drug-resistant group and 1 340 cases in the drug-responsive group. For alleles C and T, OR=0.89, 95%CI= 0.79~1.01 were obtained by fixed effect model. After excluding one marginal study, the results showed that OR=0.93, 95%CI= 0.82~1.06; the OR=0.79, 95%CI=0.67~0.92 of the recessive gene model CC/TC+TT; the OR of dominant gene model TT/TC+CC was 0.99, and 95%CI=0.80~1.23; the OR=0.86, 95%CI=0.63~1.16 of the additive gene model CC/TT; the OR=0.83 of the over-dominant gene model TT+CC/TC, and 95%CI=0.72~0.97. Conclusion There is currently no clear evidence that rs2272394, rs2272395 and rs2272400 polymorphisms of SLC6A11 gene are associated with drug-resistant epilepsy.

Key words: drug-resistant epilepsy, SLC6A11, epilepsy, genetic polymorphism.

中图分类号:

R742.1

赵明洋, 胡雪梅, 王东森, 吴庆建. SLC6A11基因多态性与耐药性癫痫之间的关联性的Meta分析[J]. 中华养生保健, 2023, 41(17): 55-60.

ZHAO Ming-yang, HU Xue-mei, WANG Dong-sen, WU Qing-jian. Meta-Analysis of Associations between Polymorphisms of SLC6A11 Genes and Drug-Resistant Epilepsy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(17): 55-60.

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