阿帕替尼联合替吉奥对晚期胃癌患者临床疗效及血清VEGF、ESM-1的影响

摘要/Abstract

摘要： 目的探究阿帕替尼联合替吉奥对晚期胃癌患者临床疗效及血清血管内皮生长因子（VEGF）、内皮细胞特异性分子-1（ESM-1）的影响。方法回顾性分析2017年1月—2022年6月日照市人民医院收治的50例晚期胃癌患者临床资料,依据化疗方案不同分成对照组（25例）和研究组（25例）。对照组予以替吉奥治疗,研究组则予以阿帕替尼与替吉奥联合治疗,均治疗2个疗程。观察两组临床疗效,对比两组治疗前后血清肿瘤标志物[再生基因蛋白Ⅳ（REGⅣ）、反应因子（SRF）和基质金属蛋白酶-2（MMP-2）]、VEGF、ESM-1水平,并开展安全性评估。结果研究组的客观缓解率高于对照组,差异有统计学意义（P<0.05）;治疗后,两组血清REGⅣ、SRF及MMP-2水平均较治疗前下降,且研究组低于对照组,差异有统计学意义（P<0.05）;治疗后,两组血清VEGF、ESM-1水平较均治疗前下降,且研究组低于对照组,差异有统计学意义（P<0.05）;两组骨髓移植、恶心呕吐、脱发、腹泻及肝肾功能异常等发生率对比,差异无统计学意义（P>0.05）。结论晚期胃癌患者运用阿帕替尼与替吉奥联合治疗具有确切效果,可更好地下调血清肿瘤标志物表达,调节血清VEGF、ESM-1水平,且不会增加不良反应的发生,安全性较高,值得临床应用。

关键词: 晚期胃癌, 阿帕替尼, 替吉奥, 临床疗效, 血管内皮生长因子, 内皮细胞特异性分子-1

Abstract: Objective To explore the clinical efficacy of Apatinib combined with Tizio in patients with advanced gastric cancer and the effects of serum vascular endothelial growth factor (VEGF) and endothelial cell specific molecule-1 (ESM-1). Methods The clinical data of 50 patients with advanced gastric cancer admitted to our hospital from January 2017 to June 2022 were retrospectively analyzed, and they were divided into control group (25 cases) and study group (25 cases) according to different chemotherapy regimen. The control group was treated with Tiggio, and the study group was treated with Apatinib combined with Tiggio for two courses. The clinical efficacy of the two groups was observed, and the levels of serum tumor markers [regenerative gene protein Ⅳ (REGⅣ), response factor (SRF) and matrix metalloproteinase-2 (MMP-2)], VEGF and ESM-1 in the two groups were compared before and after treatment, and safety assessment was carried out. Results The Objective remission rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the serum REG, SRF and MMP-2 levels in two groups were decreased compared with before treatment, and the research group was lower than the control group, the difference was statistically significant (P<0.05). After treatment, the serum VEGF and ESM-1 levels in two groups were decreased compared with before treatment, and the levels in the study group were lower than those in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of bone marrow transplantation, nausea and vomiting, alopecia, diarrhea and abnormal liver and kidney function between two groups (P>0.05). Conclusion Combined treatment with Apatinib and Tizio has a definite effect in patients with advanced gastric cancer, which can better down-regulate the expression of serum tumor markers, regulate the levels of serum VEGF and ESM-1, and does not increase the incidence of adverse reactions. It is safe and worthy of promotion.

Key words: advanced gastric cancer, Apatinib, Tizio, clinical effect, vascular endothelial growth factor, endothelial cell specific molecule-1

中图分类号:

R735.2

丁明翠, 牟玲. 阿帕替尼联合替吉奥对晚期胃癌患者临床疗效及血清VEGF、ESM-1的影响[J]. 中华养生保健, 2023, 41(17): 15-18.

DING Mingcui, MU Ling. Effect of Apatinib Combined with Tizio on Clinical Efficacy and Serum VEGF and ESM-1 in Patients with Advanced Gastric Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(17): 15-18.

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