紫仙助孕汤联合枸橼酸氯米芬对多囊卵巢综合征不孕症患者的疗效研究

摘要/Abstract

摘要： 目的研究枸橼酸氯米芬联合紫仙助孕汤对多囊卵巢综合征不孕症患者的疗效。方法选择2020年9月—2021年9月山东省聊城市人民医院收治的84例多囊卵巢综合征不孕症患者,按照随机数表法分为对照组和观察组,每组42例。对照组单用枸橼酸氯米芬,观察组联用紫仙助孕汤。记录两组的1年妊娠率和优卵排出率,检测促黄体生成素（LH）、雌二醇（E₂）、睾酮（T）和促卵泡激素（FSH）水平,评估两组的中医证候（烦躁易怒、月经不调、头晕耳鸣、情志抑郁、腰膝酸软和胸肋胀满）积分。结果观察组的1年妊娠率和优卵排出率明显高于对照组（P<0.05）。治疗前,两组的LH、E₂、T和FSH水平比较,差异无统计学意义（P>0.05）;治疗后,两组的LH、T水平均降低,E₂、FSH水平均升高（P<0.05）,且观察组变化更加明显（P<0.05）。治疗前,两组的烦躁易怒、月经不调、头晕耳鸣、情志抑郁、腰膝酸软和胸肋胀满积分比较,差异无统计学意义（P>0.05）;治疗后,两组的烦躁易怒、月经不调、头晕耳鸣、情志抑郁、腰膝酸软和胸肋胀满积分均明显降低（P<0.05）,且观察组更加明显（P<0.05）。治疗前,两组的卵巢体积和子宫内膜厚度比较,差异无统计学意义（P>0.05）;治疗后,两组的卵巢体积降低,子宫内膜厚度增加（P<0.05）,且观察组变化更加明显（P<0.05）。结论枸橼酸氯米芬联合紫仙助孕汤对多囊卵巢综合征不孕症有显著疗效,能明显提高妊娠率,减轻症状,降低卵巢体积,增加子宫内膜厚度。

关键词: 紫仙助孕汤, 枸橼酸氯米芬, 不孕症, 多囊卵巢综合征

Abstract: Objective To investigate the effect of Zixian Zhuyun decoction combined with clomiphene citrate on infertility with polycystic ovary syndrome. Methods 84 cases of polycystic ovary syndrome infertility patients admitted to the Department of Reproductive Medicine of Shandong Liaocheng People's Hospital from September 2020 to September 2021 were selected, and the random number table method was divided into two groups. The control group was treated with clomiphene citrate alone, and the observation group was treated with Zixian Zhuyun Decoction. The 1-year pregnancy rate and excellent ovulation rate of the two groups were recorded, the levels of luteinizing hormone (LH), estradiol (E₂), testosterone (T) and follicle stimulating hormone (FSH) were detected, the TCM syndromes of the two groups were evaluated, and the ovarian volume and endometrial thickness of the two groups were compared. Results The 1-year pregnancy rate and excellent egg discharge rate in the observation group were significantly higher than that in the control group (P<0.05). Before treatment, there was no significant difference in the levels of LH, E₂, T and FSH between the two groups (P>0.05). After treatment, the LH and T levels in two groups decreased, and the levels of E₂ and FSH both increased (P<0.05), and the changes in the observation group were more obvious (P<0.05). Before treatment, the scores of irritability, irregular menstruation, dizziness and tinnitus, emotional depression, waist and knee weakness and chest and rib fullness in the two groups had no significant difference (P>0.05). After treatment, the scores of irritability, irregular menstruation, dizziness and tinnitus, emotional depression, waist and knee weakness and chest and rib fullness in the two groups were significantly reduced (P<0.05), and the observation group was more significant (P<0.05). Before treatment, there was no significant difference in ovarian volume and endometrial thickness between the two groups (P>0.05). After treatment, ovarian volume decreased and endometrial thickness increased in two groups (P<0.05), and changes were more pronounced in the observation group (P<0.05). Conclusion Clomiphene citrate combined with purple fairy help pregnancy soup has a significant effect on polycystic ovary syndrome infertility, can significantly improve the pregnancy rate, reduce symptoms, reduce ovarian volume, increase endometrial thickness.

Key words: Zixian Zhuyun decoction, clomiphene citrate, sterility, polycystic ovary syndrome

中图分类号:

R711.75

付州, 张晓阳, 张凤丽. 紫仙助孕汤联合枸橼酸氯米芬对多囊卵巢综合征不孕症患者的疗效研究[J]. 中华养生保健, 2023, 41(15): 8-12.

FU Zhou, ZHANG Xiao-yang, ZHANG Feng-li. Study on Therapeutic Effect of Zixian Zhuyun Decoction Combined with Clomiphene Citrate on Infertility with Polycystic Ovary Syndrome[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(15): 8-12.

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