依降钙素联合特立帕肽治疗老年女性骨质疏松疗效的分析

摘要/Abstract

摘要： 目的探讨依降钙素联合特立帕肽治疗老年女性骨质疏松的疗效。方法选取内蒙古乌海市海勃湾区中医医院2019年1月—2022年6月收治的100例骨质疏松老年女性患者作为研究对象,应用随机数表法将其分为观察组与对照组,每组50例。对照组患者应用特立帕肽治疗,观察组患者应用依降钙素联合特立帕肽治疗,对比两组患者临床治疗效果,治疗前后骨代谢标志物1型胶原羧基端交联端肽（CTx）与骨密度（BMD）,血钙（Ca）与25羟维生素D（25-OH-D）水平以及性激素[促卵泡生成素（FSH）、孕激素（P）、雌二醇（E₂）]水平。结果观察组治疗总有效率明显高于对照组（P<0.05）;两组患者治疗前CTx、BMD对比,差异无统计学意义（P>0.05）,治疗后两组CTx、BMD均升高,且观察组高于对照组,差异有统计学意义（P<0.05）;两组患者治疗前25-OH-D、Ca水平对比,差异无统计学意义（P>0.05）,治疗后两组患者25-OH-D、Ca水平均升高,且观察组高于对照组,差异有统计学意义（P<0.05）;治疗后两组患者FSH、P、E₂水平均降低,且观察组明显低于对照组,差异有统计学意义（P<0.05）。结论采取依降钙素联合特立帕肽治疗可提升老年女性骨质疏松临床疗效,改善患者骨代谢及骨密度水平,增加血液中的钙和维生素D水平,改善性激素水平,值得临床应用。

关键词: 依降钙素, 特立帕肽, 老年女性, 骨质疏松, 骨密度, 25羟维生素D, 性激素

Abstract: Objective To explore the efficacy of leccitonin combined with teriparatide on osteoporosis in elderly women. Methods 100 patients elderly female with osteoporosis who were hospitalized in China Hospital of Heibo Bay District, Wuhai City, Inner Mongolia from January 2019 to June 2022 were selected for the study. The patients were divided into observation group and control group, with 50 cases in each group. The patients in the control group were treated with triiodol, while the patients in the observation group were treated with calcitonin combined with triiodol. The clinical effects of the two groups were compared, before and after treatment, bone metabolism marker type 1 collagen carboxyterminal cross-linked end peptide (CTx) and bone mineral density (BMD), blood calcium (Ca) and 25 hydroxyvitamin D (25-OH-D) and sex hormone [follicle hormone (FSH), progesterone (P), estradiol (E₂)] levels. Results The total response rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference between the first carboxyl crosslinked peptide (CTx) and BMD of type 1 collagen (P>0.05), CTx, and BMD were increased after treatment, And the observation group was higher than the control group (P<0.05). There was no significant difference in 25-OH-D and Ca levels between the two groups (P>0.05), 25-OH-D and Ca levels were increased in two groups, And the observation group was higher than the control group (P<0.05). After treatment, FSH, P, E₂ were decreased, And the observation group was significantly lower than the control group (P<0.05). Conclusion Which improved the bone metabolism and bone density of the elderly female patients. The increase of calcium and vitamin D levels in blood and the increase of sex hormone levels are worthy of clinical application.

Key words: ecalcitonin, teripatide, osteoporosis, elderly female, bone mineral density, 25 hydroxyvitamin D, sex hormone

中图分类号:

R589

韩梅. 依降钙素联合特立帕肽治疗老年女性骨质疏松疗效的分析[J]. 中华养生保健, 2023, 41(15): 12-15.

HAN Mei. Analysis of the Efficacy of Ieccitonin and Teriparatide in Osteoporosis in Elderly Women[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(15): 12-15.

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