小儿肺热咳喘颗粒联合布地奈德对支气管肺炎患儿的疗效观察

摘要/Abstract

摘要： 目的研究小儿肺热咳喘颗粒联合布地奈德对支气管肺炎患儿的疗效。方法选择2021年1月—2022年6月新疆昌吉州中医院收治的86例支气管肺炎患儿为研究对象,按照随机数表法将其分为对照组和观察组,每组43例。对照组单用布地奈德,观察组为小儿肺热咳喘颗粒联合布地奈德。检测并比较两组临床有效率、临床症状改善相关指标、血气指标[血氧饱和度（SpO₂）、血氧分压（PaO₂）、吸入氧浓度百分比（FiO₂）、二氧化碳分压（PaCO₂）]、肺功能指标[峰容积比（VPTEF/VE）、呼吸频率（RR）、达峰时间比（TPTEF/TE）和潮气量（VT）]和血清指标[肺表面活性蛋白 D（SP-D）、可溶性白细胞介素-2受体（sIL-2R）、干扰素-γ（INF-γ）和胰岛素样生长因子（IGF）-Ⅱ]。结果观察组治疗有效率明显高于对照组,差异有统计学意义（P<0.05）;观察组患儿的咳嗽消失时间、退热时间、喘息消失时间和肺部啰音消失时间短于对照组,差异有统计学意义（P<0.05）;治疗后,两组患儿的SpO₂、PaO₂、OI和PaCO₂均明显改善,且观察组明显优于对照组,差异有统计学意义（P<0.05）;治疗后,两组患儿的VPTEF/VE、RR、TPTEF/TE和VT均明显改善,且观察组明显优于对照组,差异有统计学意义（P<0.05）;治疗后,两组患儿血清SP-D、sIL-2R、INF-γ和IGF-Ⅱ水平均明显改善,且观察组明显优于对照组,差异有统计学意义（P<0.05）。结论小儿肺热咳喘颗粒联合布地奈德对支气管肺炎患儿有显著的疗效,值得临床应用。

关键词: 小儿肺热咳喘颗粒, 布地奈德, 支气管肺炎

Abstract: Objective To investigate the effect of Xiao'er Feire Kechuan Granules Combined with Budesonide on Children with Bronchial Pneumonia. Methods 86 cases of patients with bronchial pneumonia admitted to Xinjiang Changji Prefecture Hospital of TCM from January 2021 to December 2022 were selected, and were divided into two groups randomly. The control group was treated with budesonide alone, and the observation group was pediatric pulmonary hot cough and asthma particles combined with budesonide. Indices related to clinial manifestation, blood gas indices [SpO₂, PaO₂, FiO₂, PaCO₂], lung function indices [VPTEF/VE, RR, TPTEF/TE and VT] and serum indexes [pulmonary surfactant protein D (SP-D), soluble interleukin-2 receptor (sIL-2R), interferon- γ (INF- γ), insulin like growth factor (IGF-Ⅱ)] were detected and compared. Results The effective rate of the observation group was significantly higher than that of the control group (P<0.05). The disappearance time of cough, fever, wheezing and lung rale in the observation group were shorter (P<0.05). After treatment, the SpO₂, PaO₂, OI and PaCO₂ in the two groups were significantly improved (P<0.05), and the observation group were significantly better than those in the control group (P<0.05). After treatment, VPTEF/VE, RR, TPTEF/TE and VT in the two groups were significantly improved (P<0.05), and the observation group were significantly better than those in the control group (P<0.05). After treatment, serum SP-D, sIL-2R, INF-γAnd IGF-Ⅱ levels were significantly improved (P<0.05), and the control group were significantly higher than those in the control group (P<0.05). Conclusion Xiao'er Feire Kechuan Granules combined with budesonide has a significant effect on children with bronchopneumonia, which is worth promoting.

Key words: Xiao'er feire kechuan Granules, budesonide, bronchopneumonia

中图分类号:

R725.6

杨先华, 鲁彩霞. 小儿肺热咳喘颗粒联合布地奈德对支气管肺炎患儿的疗效观察[J]. 中华养生保健, 2023, 41(14): 28-31.

YANG Xian-hua, LU Cai-xia. Effect of Xiao'er Feire Kechuan Granules Combined with Budesonide on Children with Bronchial Pneumonia[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(14): 28-31.

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