加味清中汤联合脱敏治疗过敏性结膜炎疗效

摘要/Abstract

摘要： 目的观察加味清中汤联合脱敏治疗过敏性结膜炎疗效的影响。方法选取2020年3月—2022年3月北京中医药大学第三附属医院密云院区收治的100例过敏性结膜炎患者为研究对象,根据治疗方法分为观察组与对照组,每组50例。对照组采用脱敏治疗,观察组在脱敏治疗的基础上联合加味清中汤治疗,比较两组治疗效果、炎症因子水平、泪膜功能、临床症状。结果观察组治疗有效率高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者白细胞介素（IL）-5、IL-4、IL-8、肿瘤坏死因子（TNF-α）水平比较,差异无统计学意义（P>0.05）;治疗后,两组患者IL-5、IL-4、IL-8、TNF-α水平均降低,且观察组患者IL-5、IL-4、IL-8、TNF-α水平降低幅度大于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者的角膜荧光素染色（FL）评分、泪膜破裂时间（BUT）、泪液分泌试验（SIT）结果比较,差异无统计学意义（P>0.05）,治疗后,两组患者FL评分降低,SIt、BUT水平升高,且治疗后观察组患者以上指标变化幅度大于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者结膜充血、分泌物增多、眼氧、流泪等症状评分比较,差异无统计学意义（P>0.05）;治疗后,两组患者结膜充血、分泌物增多、眼氧、流泪等症状评分均降低,且治疗后观察组患者以上指标评分均低于对照组,差异有统计学意义（P<0.05）。结论给予过敏性结膜炎患者加味清中汤联合脱敏治疗,能提高治疗效果,减轻炎症反应,促进泪膜功能、临床症状的改善,值得临床应用。

关键词: 加味清中汤, 脱敏, 过敏性结膜炎, 疗效, 炎症因子

Abstract: Objective To observe the effect of Jiawei Qingzhong Decoction combined with desensitization on allergic conjunctivitis. Methods A total of 100 patients with allergic conjunctivitis (from March 2020 to March 2022) admitted to Miyun Hospital, the Third Affiliated Hospital of Beijing University of Chinese Medicine were selected and divided into control group (50 cases) and observation group (50 cases). The control group was treated with desensitization, and the observation group was treated with Jiaweiqingzhong Decoction on the basis of desensitization treatment. The therapeutic effect, inflammatory factors, tear film function and clinical symptoms were observed. Results The effective rate of observation group was higher than that of control group (P<0.05). The levels of IL-5, IL-4, IL-8 and TNF-α were not significantly different between the two groups before treatment (P>0.05). The levels of IL-5, IL-4, IL-8 and TNF-α were all decreased between the two groups after treatment, and the above indexes in the observation group were reduced more than that in the control group after treatment. The differences were statistically significant (P<0.05). Before treatment, there was no significant difference in the levels of FL, SIt and BUT between the two groups (P>0.05). After treatment, the levels of FL decreased and SIt and BUT increased between the two groups, and the change range of the above indexes in the observation group was greater than that in the control group. The differences were statistically significant (P<0.05). Before treatment, there was no statistical significance in symptom scores of conjunctival congestion, increased secretions, ocular oxygen and tears between the two groups (P>0.05). After treatment, symptom scores of conjunctival congestion, increased secretions, ocular oxygen and tears between the two groups were decreased, and after treatment, the above index scores of the observation group were lower than that of the control group. The differences were statistically significant (P<0.05). Conclusion Jiawei Qingzhong Decoction combined with desensitization treatment for patients with allergic conjunctivitis can improve the therapeutic effect, reduce inflammation, promote the improvement of tear film function and clinical symptoms, which is worth reference.

Key words: Jiawei Qingzhong Soup, desensitization, allergic conjunctivitis, efficacy, inflammatory factor

中图分类号:

R777.31

王晓娟. 加味清中汤联合脱敏治疗过敏性结膜炎疗效[J]. 中华养生保健, 2023, 41(11): 32-34.

WANG Xiao-juan. Effect of Jiawei Qingzhong Decoction Combined with Desensitization on Allergic Conjunctivitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(11): 32-34.

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