膝关节滑液补体C3水平与膝关节炎的相关性分析

摘要/Abstract

摘要： 目的探讨与分析膝关节滑液补体C3水平与膝关节炎的相关性。方法选择2018年7月—2021年5月在山东省平阴县中医医院诊治的126名膝关节炎患者作为膝关节炎组,同期选择无膝关节炎的126名体检者作为对照组,检测并比较膝关节炎组与对照组膝关节滑液补体C3、C4、血清抗核抗体、环瓜氨酸肽指标水平,评定膝关节炎患者的KL分级评分,分析患者的KL分级评分与补体C3水平的相关性。结果膝关节炎组膝关节滑液补体C3水平高于对照组（P<0.05）。膝关节炎组血清抗核抗体、C4、环瓜氨酸肽含量高于对照组（P<0.05）,两组免疫球蛋白（Ig）G含量比较,差异无统计学意义（P>0.05）。在膝关节炎组中,KL分级评分为（6.33±0.52）分,Pearson相关性分析显示KL分级评分与膝关节滑液补体C3和血清抗核抗体、C4、环瓜氨酸肽都存在正相关性（P<0.05）;在膝关节炎组中,非条件Logistic回归分析显示膝关节滑液补体C3、血清抗核抗体和血清C4、环瓜氨酸肽为影响KL分级评分的重要危险因素（P<0.05）。结论膝关节炎患者多伴随膝关节滑液补体C3水平的高表达,与患者的KL分级评分存在相关性,也是影响KL分级评分的重要因素。

关键词: 膝关节炎, 关节滑液, 补体C3, KL分级评分, 抗核抗体, 相关性, 环瓜氨酸肽

Abstract: Objective To investigate and analyze the correlation between the level of complement C3 in knee synovial fluid and knee arthritis. Methods From July 2018 to May 2021 in the hospital of traditional Chinese medicine of knee arthritis in 126 patients as 126 cases, in the same period, 126 cases of healthy physical examination of knee arthritis were selected as the control group, the level of knee synovial complement C3 and other serological indicators, the KL grade score of the patients with knee arthritis was evaluated, and the correlation between the KL grade score and complement C3 levels were analyzed. Results The level of complement C3 in the synovial fluid of the knee arthritis group were higher than that of the control group (P<0.05). The serum levels of antinuclear antibody (ANA), C4, cyclic citrullinated peptide (CCP) in the knee arthritis group were higher than those in the control group (P<0.05), and the immunoglobulin G levels compared were no statistically significant difference between the two groups (P>0.05). In the knee arthritis group, the KL grading score were (6.33±0.52) points. Pearson correlation analysis showed that the KL grading score were positively correlated with knee synovial fluid complement C3 and serum ANA, C4, CCP(P<0.05); in the knee arthritis group, unconditioned logistic regression analysis showed that knee synovial fluid complement C3, antinuclear antibodies, serum C4, and cyclocitrulline peptides served as important risk factors affecting the KL grade score (P<0.05). Conclusion Patients with knee arthritis are mostly accompanied by high expression of complement C3 in the synovial fluid of the knee joint, which are correlated with the patient's KL grading score and are also important factors affecting the KL grading score.

Key words: knee arthritis, joint synovial fluid, complement C3, KL grade score, antinuclear antibody, correlation, cyclic citrullinated peptide

中图分类号:

R684.3

王培波, 刘二红, 李燕. 膝关节滑液补体C3水平与膝关节炎的相关性分析[J]. 中华养生保健, 2023, 41(11): 25-27.

WANG Pei-bo, LIUI Er-hong, LI Yan. Correlation of Complement C3 Level of Knee Joint Synovial Fluid and Knee Arthritis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(11): 25-27.

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