血清总IgE、过敏原特异性IgE联合嗜酸性粒细胞检测在特应性皮炎诊断中的应用研究

摘要/Abstract

摘要： 目的探讨血清总免疫球蛋白E（IgE）、过敏原特异性IgE（sIgE）联合嗜酸性粒细胞（EOS）检测在特应性皮炎诊断中的临床价值。方法回顾性分析2020年1月~2022年1月日照市皮肤病防治所收治的72例特应性皮炎患者的临床资料,并纳入观察组,同期体检的60名健康体检者设为对照组。所有入选研究对象均采血检测血清总IgE、sIgE、EOS水平。比较两组血清总IgE、sIgE、EOS水平,并以SCORAD评分对特应性皮炎患者严重程度进行分级,比较不同严重程度总IgE、sIgE、EOS水平;比较血清总IgE、sIgE、EOS及联合检测在特应性皮炎患者中阳性检出情况;绘制受试者工作曲线（ROC）,分析血清总IgE、sIgE、EOS及联合检测在特应性皮炎诊断中的临床价值;采用Pearson相关性分析血清总IgE、sIgE及EOS水平与严重程度的相关性。结果观察组血清总IgE、sIgE及EOS水平高于对照组,差异有统计学意义（P<0.05）;重度特应性皮炎患者总IgE、sIgE及EOS水平高于中度、轻度患者,差异有统计学意义（P<0.05）;联合检测阳性率高于总IgE、sIgE及EOS单一检测,差异有统计学意义（P<0.05）;绘制ROC曲线显示,总IgE、sIgE、EOS单一检测及联合检测诊断特应性皮炎的曲线下面积（AUC）分别为0.808、0.828、0.746、0.963,联合检测诊断价值最高;血清总IgE、sIgE及EOS水平与SCORAD评分呈正相关（r=0.421、0.513、0.387,P<0.05）。结论血清总IgE、sIgE联合EOS检测可提高特应性皮炎诊断准确性,且上述指标与疾病严重程度呈正相关,可为明确患者病情提供参考。

关键词: 特应性皮炎, 免疫球蛋白E, 嗜酸性粒细胞, 诊断价值

Abstract: Objective To investigate the clinical value of serum total immunoglobulin E (IgE), allergen-specific IgE (sIgE) combined with eosinophils (EOS) in the diagnosis of atopic dermatitis. Methods The clinical data of 72 patients with atopic dermatitis admitted to Rizhao City Dermatology Prevention and Treatment Center from January 2020 to January 2022 were retrospectively analyzed and included in the observation group. All selected subjects were collected blood to detect serum total IgE, sIgE and EOS levels. Serum levels of total IgE, sIgE, and EOS were compared between the two groups, and the severity of atopic dermatitis patients was graded by SCORAD score, and the levels of total IgE, sIgE, and EOS between different severity levels were compared; Positive detection in patients with atopic dermatitis; receiver operating curve (ROC) was drawn to analyze the clinical value of serum total IgE, sIgE, EOS and combined detection in the diagnosis of atopic dermatitis; Pearson correlation analysis was used Correlation between serum total IgE, sIgE and EOS levels and severity. Results The serum total IgE,sIgE and EOS levels in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05);the positive rate of combined detection was higher than that of total IgE,sIgE and EOS single detection, and the difference was statistically significant (P<0.05).The areas under the curve (AUC) for the detection and diagnosis of atopic dermatitis were:0.808,0.828,0.746,and 0.963,respectively,and the combined detection had the highest diagnostic value;serum total IgE,sIgE and EOS levels were positively correlated with the SCORAD score (r=0.421,0.513,0.387,P<0.05). Conclusion Serum total IgE,sIgE combined with EOS detection can improve the diagnostic accuracy of atopic dermatitis,and the above indicators are positively correlated with the severity of the disease,which can provide a reference for clarifying the patient’s condition.

Key words: atopic dermatitis, immunoglobulin E, eosinophils, diagnostic value

中图分类号:

R446.62

王云鹏, 杨瑞海, 李芳, 李桂双. 血清总IgE、过敏原特异性IgE联合嗜酸性粒细胞检测在特应性皮炎诊断中的应用研究[J]. 中华养生保健, 2023, 41(1): 19-22.

WANG Yun-peng, YANG Rui-hai, LI Fang, LI Gui-shuang. Application of Serum Total IgE and Allergen-Specific IgE Combined with Eosinophil Detection in the Diagnosis of Atopic Dermatitis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(1): 19-22.

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