复方α-酮酸联合阿托伐他汀治疗慢性肾功能衰竭的影响

摘要/Abstract

摘要： 目的研究复方α-酮酸联合阿托伐他汀治疗慢性肾功能衰竭的临床效果。方法回顾性选择2019年1月~2021年12月盘锦辽油宝石花医院收治的860例慢性肾功能衰竭患者,根据治疗方法的不同分为观察组与对照组,每组430例。两组均采取低蛋白饮食,控制血压、血脂和血糖;对照组采取复方α-酮酸治疗,观察组采用联合阿托伐他汀治疗。两组均治疗2个月,比较两组的临床效果,且检测两组治疗前后的血清尿素氮（BUN）、血肌酐（Scr）、胆固醇（TC）、白蛋白（ALB）、甘油三酰（TG）、血钙、甲状旁腺素（PTH）和血磷水平。结果观察组慢性肾功能衰竭患者的有效率高于对照组（P<0.05）。治疗前,两组的Scr、BUN、TG和 TC比较,差异无统计学意义（P>0.05）;治疗后,两组慢性肾功能衰竭患者的Scr、BUN、TG和 TC降低（P<0.05）,ALB升高（P<0.05）,且观察组慢性肾功能衰竭患者的Scr、BUN、TG和TC低于对照组（P<0.05）,ALB高于对照组（P<0.05）。治疗前,两组的血钙、PTH和血磷水平比较,差异无统计学意义（P>0.05）;治疗后,两组慢性肾功能衰竭患者的血钙、PTH和血磷水平比较,差异无统计学意义（P>0.05）。结论复方α-酮酸联合阿托伐他汀能有效保护肾功能,降低血脂,有效延缓肾脏衰竭的进程。

关键词: 复方α-酮酸, 阿托伐他汀, 慢性肾功能衰竭

Abstract: Objective To study the clinical effect of compound α-ketoacid combined with atorvastatin in the treatment of chronic renal failure. Methods A total of 860 patients with chronic renal failure admitted to Panjin Liaoyou Baoshihua Hospital from January 2019 to December 2021 were retrospectively selected and divided into observation group and control group according to different treatment methods, with 430 cases in each group. Both groups adopted low protein diet to control blood pressure and blood glucose; the observation group was treated with compound alpha-ketoacid combined with atorvastatin. The two groups were treated for 2 months,and the clinical effects of the two groups were compared. Serum urea nitrogen(BUN),,serum creatinine (Scr),,cholesterol (TC),,albumin (ALB),,triglyceride (TG),,serum calcium,parathyroid hormone (PTH) and serum phosphorus in the two groups before and after treatment were detected level. Results The effective rate of the observation group was significantly higher than control group(P<0.05). Before treatment, there was no significant difference in SCR, bun, TG and TC between the two groups (P>0.05). After treatment,,SCR,,BUN, TG and TC decreased significantly(P<0.05), ALB increased significantly (P<0.05), and SCR, bun, TG and TC in the observation group were significantly lower than those in the control group(P<0.05), ALB was significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in the levels of blood calcium, PTH and blood phosphorus between the two groups(P>0.05). After treatment, there was no significant change in the levels of blood calcium, PTH and blood phosphorus in the two groups (P>0.05). Conclusion Compound alpha-ketoacid combined with atorvastatin can effectively protect renal function, reduce blood phosphorus, increase blood calcium content, inhibit PTH secretion, and effectively delay the process of renal failure.

Key words: compound α-ketoacid, atorvastatin, chronic renal failure

中图分类号:

R692

高菊. 复方α-酮酸联合阿托伐他汀治疗慢性肾功能衰竭的影响[J]. 中华养生保健, 2022, 40(22): 50-52.

GAO Ju. Effect of Compound α-Ketoacids Combined with Atorvastatin on Chronic Renal Failure[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(22): 50-52.

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