中西医结合治疗脑梗死疗效的Meta分析

摘要/Abstract

摘要： 目的采用Meta分析系统评价中西医结合方案治疗脑梗死的临床效果。方法以“脑梗死”、“缺血性脑卒中”、“中西医结合”、“随机对照试验（RCTs）”为关键词,在中文科技期刊数据库（VIP）、万方数据库（WFD）、中国知网（CNKI）、中国生物医学文献数据库（CBM）中检索。检索年限范围是2017年1月~2022年1月。获取文献中相关有效的原始数据,通过RveMan5.3软件进行文献质量评价,同时使用RveMan5.3进行数据分析,其中通过敏感性分析来评估文献结果的稳定性,同时采用漏斗图来评估文献可能存在的发表偏倚。结果本次共检索中文文献1 447篇,根据纳入和排除的标准,本次Meta分析共纳入9篇文献,行异质性检验提示研究间存在中度异质性,采用随机效应模型进行效应量的合并;通过敏感性分析去除“熊海涛2017”后研究间不存异质性,采用固定效应模型进行总效应值合并,合并相对危险度（RR）[95%置信区间]为1.22[1.14,1.30],结果显示中西医结合方案治疗脑梗死的临床效果优于单纯的西医治疗方案（Z=5.91,P<0.001）;另外漏斗图显示左右两侧基本对称,提示发表偏倚可能较小。结论在临床治疗中,采用中西医结合治疗方案的临床效果胜于单纯的西医治疗方案。

关键词: 中西医结合, 脑梗死, 脑卒中, Meta分析

Abstract: Objective To systematically evaluate the clinical effect of integrated traditional Chinese and western medicine in the treatment of cerebral infarction by meta-analysis. Methods Using “cerebral infarction”, “ischemic stroke”, “integration of traditional Chinese and Western medicine”, “randomized controlled trials (RCTs)” as key words, data were collected in the Chinese Science and Technology Periodical Database (VIP) and Wanfang Database (WFD), China National Knowledge Infrastructure (CNKI), and China Biomedical Literature Database (CBM). The retrieval period ranged from January 2017 to January 2022, and relevant and valid original data in the literature were obtained, and the quality of the literature was evaluated by RveMan5.3 software. At the same time, RveMan5.3 was used for data analysis, which was evaluated by sensitivity analysis. The stability of the literature results, and the use of funnel plots to assess the possible publication bias of the literature. Results A total of 1447 Chinese literatures were retrieved in this study. According to the inclusion and exclusion criteria, a total of 9 literatures were included in this Meta-analysis. The heterogeneity test indicated that there was moderate heterogeneity among the studies, and a random effect model was used to determine the effect size. There was no heterogeneity between studies after Xiong Haitao 2017 was removed by sensitivity analysis, and the fixed effect model was used to merge the total effect value, and the combined RR (95%CI) was 1.22 (1.14, 1.30). The clinical effect of cerebral infarction was better than that of simple western medicine treatment (Z=5.91, P<0.001). In addition, the funnel plot showed that the left and right sides were basically symmetrical, suggesting that the publication bias may be small. Conclusion In clinical treatment, the clinical effect of the integrated traditional Chinese and western medicine treatment plan is better than the simple western medicine treatment plan.

Key words: integrated traditional Chinese and Western medicine, cerebral infarction, stroke, Meta-analysis

中图分类号:

R454.9

何明龙. 中西医结合治疗脑梗死疗效的Meta分析[J]. 中华养生保健, 2022, 40(21): 68-72.

HE Ming-long. A Meta-analysis of the Efficacy of Integrated Traditional Chinese and Western Medicine in the Treatment of Cerebral Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(21): 68-72.

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