盐酸川芎嗪注射液联合尤瑞克林对急性脑梗死的疗效及对Ang-Ⅱ、D-二聚体、hs-CRP水平的影响

摘要/Abstract

摘要： 目的研究盐酸川芎嗪注射液联合尤瑞克林对急性脑梗死的疗效及对血管紧张素Ⅱ（ Ang-Ⅱ）、D-二聚体、超敏C-反应蛋白（hs-CRP）水平的影响。方法回顾性分析2019年1月~2021年12月石河子市人民医院收治的76例急性脑梗死患者的临床资料,根据治疗方法分为对照组和观察组,各38例。对照组给予尤瑞克林治疗;观察组在尤瑞克林的基础上,联用盐酸川芎嗪注射液治疗。两组患者均治疗14天,观察两组患者的治疗有效率、治疗前后血浆D-二聚体、血管紧张素Ⅱ（Ang-Ⅱ）、血清超敏C-反应蛋白（hs-CRP）水平及脑血流动力学指标（大脑后动脉血流速度、血细胞比容水平、大脑中动脉血流速度、全血低切黏度、大脑前动脉血流速度以及全血高切黏度）。结果观察组急性脑梗死患者的治疗有效率高于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者的Ang-Ⅱ、D-二聚体和hs-CRP水平比较,差异无统计学意义（P>0.05）;治疗后,两组患者的Ang-Ⅱ、D-二聚体和hs-CRP水平均明显降低,差异有统计学意义（P<0.05）,且观察组水平明显低于对照组,差异有统计学意义（P<0.05）。治疗前,两组患者的大脑后动脉血流速度、血细胞比容水平、大脑中动脉血流速度、全血低切黏度、大脑前动脉血流速度以及全血高切黏度比较,差异无统计学意义（P>0.05）;治疗后,两组患者的各项指标均明显改善,差异有统计学意义（P<0.05）,且观察组指标均明显优于对照组,差异具有统计学意义（P<0.05）。结论盐酸川芎嗪注射液联合尤瑞克林在急性脑梗死治疗中有显著疗效,其机制可能与降低Ang-Ⅱ、D-二聚体、hs-CRP水平有关。

关键词: 盐酸川芎嗪注射液, 尤瑞克林, 急性脑梗死, 血管紧张素Ⅱ, D-二聚体, 超敏C-反应蛋白

Abstract: Objective To study the effect of ligustrazine hydrochloride injection combined with urecolin on acute cerebral infarction and the levels of angiotensin Ⅱ(Ang -Ⅱ), D-dimer and high-sensitivity C-reactive protein (hs-CRP). Methods A retrospective study of 76 patients with acute cerebral infarction admitted to Shihezi People's Hospitalfrom January 2019 to December 2021 were retrospectively selected and divided into two groups according to the treatment methods, with 38 cases in each group. The control group was given Eurekrine treatment; the observation group was treated with Ligustrazine Hydrochloride Injection on the basis of Eurekrine. The two groups were treated for 14 days, and the effective rates of treatment in the two groups were observed, plasma D-dimer, angiotensin II (Ang-II), serum high-sensitivity C-reactive protein (hs-CRP) levels and cerebral blood Fluid dynamics indicators (posterior cerebral artery blood flow velocity, hematocrit level, middle cerebral artery blood flow velocity, whole blood low shear viscosity, anterior cerebral artery blood flow velocity, and whole blood high shear viscosity). Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the levels of Ang-Ⅱ, D-dimer and hs-CRP between the two groups (P>0.05). After treatment, the levels of Ang-Ⅱ, D-dimer and hs-CRP in the two groups decreased significantly (P<0.05), and the levels of Ang-Ⅱ, D-dimer and hs CRP in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in hematocrit, anterior cerebral artery blood flow velocity, whole blood high shear viscosity, middle cerebral artery blood flow velocity, whole blood low shear viscosity and posterior cerebral artery blood flow velocity between the two groups (P>0.05). After treatment, all indicators in the two groups were significantly improved (P<0.05),andthe indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion Ligustrazine hydrochloride injection combined with urecolin has a significant effect on acute cerebral infarction, and its mechanism may be related to reducing the levels of Ang -Ⅱ, D-dimer and hs-CRP.

Key words: ligustrazine hydrochloride injection, eureklin, acute cerebral infarction, angiotensin II, D-dimer, high sensitivity C-reactive protein

中图分类号:

R473.3

亚·娜仁, 甄作睿. 盐酸川芎嗪注射液联合尤瑞克林对急性脑梗死的疗效及对Ang-Ⅱ、D-二聚体、hs-CRP水平的影响[J]. 中华养生保健, 2022, 40(15): 11-15.

Ya Na-ren,Zhen Zuo-rui. Effect of Ligustrazine Hydrochloride Injection Combined with Urecolin on Acute Cerebral Infarction and the Ievels of Ang - Ⅱ, D-dimer and hs-CRP[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(15): 11-15.

参考文献

[1] 宗寿健,王兴臣,孙贵芝,等.老年急性脑梗死患者血清降钙素原水平与病灶体积和神经功能缺损的相关分析[J].中华老年心脑血管病杂志,2021,23(9):958-960.
[2] 辛奕,周胜利,顾艳,等.CTP及ASL技术在脑梗死患者缺血半暗带评估中的应用价值[J].医学影像学杂志,2021,31(8):1274-1277.
[3] 陈进英,周友田,徐习.老年脑梗死患者肢体功能障碍康复训练及物理技术的研究进展[J].老年医学与保健,2021,27(3):670-673.
[4] 楼赵彦,宋水江.阿替普酶注射剂联合瑞舒伐他汀钙片治疗急性脑梗死患者的临床研究[J].中国临床药理学杂志,2020,36(11):1413-1415.
[5] 尤晓涵,杨淼,明霞光,等.盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J].陕西中医,2020,41(6): 743-745,757.
[6] 中华医学会神经病学分会,中华医学会神经病学会分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,43(5):246-257.
[7] 孙逸夫,肖成华,陆军,等.急性脑梗死患者不同MS组分对其血小板聚集功能的影响及相关性研究[J].徐州医学院学报,2020,40(3):185-189.
[8] 文丽娜,张晶晶,高嫚,等.针对性健康指导干预对2型糖尿病合并急性脑梗死患者血糖水平及脑梗死预后的影响[J].中国医药,2020, 15(7):1041-1044.
[9] Lee S H, Jung J M, Kim K Y, et al.Intramural Hematoma Shape and Acute Cerebral Infarction in Intracranial Artery Dissection:A High-Resolution Magnetic Resonance Imaging Study[J].Cerebrovascular Diseases,2020,49(3):1-8.
[10] 周晓磊,黄淑芳,易芹,等.丹参川芎嗪联合依达拉奉治疗急性脑梗死临床研究的系统评价[J].世界中西医结合杂志,2020,15(2):60-66,110.
[11] 胡瑞学,于丹丹,李慧敏,等.基于2种复杂网络分析方法探索活血化瘀类中药注射液治疗急性脑梗死的疗效[J].中国中药杂志,2021, 46(14):3722-3731.
[12] 李婷婷,孙千惠,王博远,等.脉血康胶囊治疗急性脑梗死的临床疗效及安全性系统评价和GRADE证据级别评价[J].中草药,2021, 52(2):483-494.
[13] 佘颜,龙须,邓常清,等.中风Ⅱ号方对急性脑梗死患者血管内皮损伤及炎症反应的影响[J].中国中西医结合急救杂志,2021,28(6):653-657.
[14] 祁景,刘小军,祁邵艳,等.盐酸川芎嗪联合奥扎格雷对急性脑梗死患者神经功能缺损和血液流变学的影响[J].世界中西医结合杂志,2020,15(4):710-713.
[15] 尤晓涵,杨淼,明霞光,等.盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J].陕西中医,2020, 41(6):743-745,757.
[16] 邵帅,滕跃华,王倩.高压氧治疗对急性脑梗死患者神经功能恢复及血清VEGF,Ang-2,NSE水平的影响[J].中国医师杂志,2022, 24(3):436-439.
[17] 钟可文,孙华,赵玉环,等.血同型半胱氨酸,纤维蛋白原,D-二聚体联合检测在急性脑梗死诊断中的临床意义[J].安徽医药,2020, 24(9):1803-1805.
[18] 李兴明,刘娟娟,陈俊斌,等.复方脑肽节苷脂注射液对急性脑梗死的临床疗效及对患者Lp-PLA2 hs-CRPNSE水平的影响[J].河北医学,2020,26(3):393-397.
[19] 李海霞,祁香兴,张祖善.不同NIHSS评分的急性脑梗死病人Lp-PLA2,hs-CRP,D-D表达水平及其意义分析[J].中西医结合心脑血管病杂志,2020,18(11):1804-1807.
[20] 王珊玉,冯毅,胡丽莉.中医化痰通络法对急性脑梗死缺血再灌注损伤患者神经,运动功能及高敏C反应蛋白,同型半胱氨酸的影响[J].现代中西医结合杂志,2020,29(26):2945-2948.