安宫牛黄丸治疗颅脑损伤后脑血管痉挛的临床效果

中华养生保健 ›› 2022, Vol. 40 ›› Issue (15): 1-4.

• 论著 • 下一篇

安宫牛黄丸治疗颅脑损伤后脑血管痉挛的临床效果

徐龙彪¹, 黄欢明², 吴天涯², 朱家明², 陈诗琪¹, 万烨东¹, 王冠华^3,*

1. 浙江中医药大学附属第三医院神经外科,浙江杭州,310000;
2. 诸暨市人民医院神经外科,浙江绍兴,311800;
3. 温州市中西医结合医院外科,浙江温州,325001

出版日期:2022-08-01 发布日期:2022-07-26
通讯作者: *王冠华,E-mail：wgh991066@126.com。
作者简介:徐龙彪（1989.7-）,男,汉族,籍贯：浙江省绍兴市,硕士研究生,主治医师,研究方向：神经外科（重型颅脑外科和急性脑血管意外的手术抢救治疗）。
基金资助:
2020浙江省卫生健康委科技项目（2020PY081）; 2021年浙江省医学会临床科研基金项目（2021ZYC-A190）; 2022年浙江省医学会临床科研基金项目（2022ZYC-A11)

Clinical Effect of Angong Niuhuang Pill in the Treatment of Cerebral Vasospasm after Craniocerebral Injury

XU Long-biao¹, HUANG Huan-ming², WU Tian-ya², ZHU Jia-ming², CHEN Shi-qi¹, WAN Ye-dong¹, WANG Guan-hua^{3, *}

1. Department of Neurosurgery, The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou Zhejiang, 310000, China;
2. Department of Neurosurgery, Zhuji People's Hospital, Shaoxing Zhejiang, 311800, China;
3. Department of Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, WenzhouZhejiang, 325001, China

Online:2022-08-01 Published:2022-07-26

摘要/Abstract

摘要： 目的研究安宫牛黄丸治疗颅脑损伤患者后脑血管痉挛的临床效果。方法选取2019年6月~2021年6月诸暨市人民医院收治的颅脑损伤术后脑血管痉挛患者72例,按随机数表法分为对照组和治疗组,每组36例。对照组选用常见的治疗方法并合并基础治疗手段;治疗组在对照组治疗的基础上加用安宫牛黄丸治疗。比较两组患者治疗前和治疗14 d后格拉斯评分（GCS）的变化,同时比较两组患者经颅多普勒超声测定的大脑中动脉血流速度。结果治疗组大脑中动脉血流速度在治疗后3、7、14 d均明显低于对照组,差异有统计学意义（P<0.05）。治疗组治疗后格拉斯评分明显高于对照组,差异有统计学意义（P<0.05）。结论安宫牛黄丸对于脑外伤术后患者具有扩张血管、抑制钙离子内流的作用,从而减轻脑水肿,调节脑血流量,降低大脑中动脉均值流速,减少了创伤性脑血管痉挛的发生,起到促进脑功能恢复的作用。

关键词: 安宫牛黄丸, 尼莫地平, 创伤性脑血管痉挛

Abstract: Objective To study the therapeutic effect of Angong Niuhuang Pill on cerebral vasospasm in patients with craniocerebral injury. Methods A total of 72 patients with cerebral vasospasm admitted to Zhuji People's Hospital after craniocerebral injury from June 2019 to June 2021 were selected and divided into the control group and the treatment group, with 36 cases in each groups.The control group was treated with common treatment methods combined with basic treatment methods; the treatment group was additionally treated with Angong Niuhuang Pill on the basis of the treatment of the control group.The changes of Glass Score (GCS) before and after 14 days of treatment were compared between the two groups, and the blood flow velocity of the middle cerebral artery was measured by transcranial Doppler ultrasound and was compared between the two groups. Results The blood flow velocity of the middle cerebral artery in the treatment group was significantly lower than that in the control group at 3, 7, and 14 days after treatment, and the difference was statistically significant(P<0.05).The Glass score after treatment in the treatment group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion Angong Niuhuang Pill has the effect of dilating blood vessels and inhibiting the inward flow of calcium ions in post-traumatic brain injury patients, thereby reducing cerebral edema, regulating cerebral blood flow, reducing the average flow rate of the middle cerebral artery, and therefore reducing the occurrence of traumatic cerebral vasospasm.

Key words: Angong Niuhuang Pill, nimodipine, traumatic cerebral vasospasm

中图分类号:

R651

徐龙彪, 黄欢明, 吴天涯, 朱家明, 陈诗琪, 万烨东, 王冠华. 安宫牛黄丸治疗颅脑损伤后脑血管痉挛的临床效果[J]. 中华养生保健, 2022, 40(15): 1-4.

XU Long-biao, HUANG Huan-ming, WU Tian-ya, ZHU Jia-ming, CHEN Shi-qi, WAN Ye-dong, WANG Guan-hua. Clinical Effect of Angong Niuhuang Pill in the Treatment of Cerebral Vasospasm after Craniocerebral Injury[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(15): 1-4.

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安宫牛黄丸治疗颅脑损伤后脑血管痉挛的临床效果

Clinical Effect of Angong Niuhuang Pill in the Treatment of Cerebral Vasospasm after Craniocerebral Injury

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