晚期非小细胞肺癌患者采用化学治疗联合靶向药物治疗的临床疗效

摘要/Abstract

摘要： 目的分析晚期非小细胞肺癌（non-small cell lung cancer,NSCLC）疾病特点,探究化学治疗联合靶向药物治疗的临床效果。方法选取国药北方医院2019年10月~2020年10月收治的80例NSCLC患者为研究对象,按照随机数表法分为对照组与观察组,每组40例。对照组患者采取化学治疗,观察组患者采取化学治疗联合靶向药物治疗。比较两组NSCLC患者的治疗情况,包括治疗效果、不良反应、生活质量、肺功能指标水平。结果观察组NSCLC患者的欧洲癌症研究与治疗组织生活质量测定量表（European organzation for research and treatment of cancer quality of life-C30,EORTC QLQ-C30）评分高于对照组,差异有统计学意义（P<0.05）。观察组NSCLC患者的用力肺活量（forced vital capacity,FVC）、第1秒用力呼气容积（forced expiratory volume in one second,FEV₁）均高于对照组,差异有统计学意义（P<0.05）。观察组NSCLC患者的临床治疗总有效率高于对照组,差异有统计学意义（P<0.05）。观察组NSCLC患者的恶心呕吐、皮疹、腹泻、骨髓抑制等不良反应发生率低于对照组,差异有统计学意义（P<0.05）。结论 NSCLC患者行化学治疗联合靶向药物治疗,可以提升疾病治疗效果、患者的肺功能,进而提升患者的生活质量,且安全性较高。

关键词: 非小细胞肺癌, 化学治疗, 靶向药物治疗, 治疗效果, 不良反应

Abstract: Objective To study the efficacy of chemotherapy combined with targeted drug therapy in patients with advanced non-small cell lung cancer （NSCLC）. Methods A total of 80 patients with NSCLC who were admitted and treated in Sinopharm North Hospital from October 2019 to October 2020 were selected. They were randomly divided into two groups, the observation group and the control group.The control group received chemotherapy, while the observation group received chemotherapy combined with targeted drug therapy. The the prognosis of NSCLC patients in the two groups were compared, including treatment effect and adverse reactions, quality of life and lung function. Results The European Organization for Research and Treatment of Cancer （EORTC QLQ-C30） score in the observation group was significantly higher than that in the control group （P<0.05）. The forced vital capacity （FVC） and forced expiratory volume in one second （FEV₁） of patients in the observation group were significantly higher than those in the control group （P<0.05）. The total effective rate in the observation group was significantly higher than that in the control group （P<0.05）; the incidences of adverse reactions such as nausea, vomiting, rash, diarrhea, and bone marrow suppression in the observation group were significantly less than those in the observation group were significantly lower than those in the control group （P<0.05）. Conclusion Chemotherapy combined with targeted drugscould improve the clinical efficacy and lung function of NSCLC patients, while improving the quality of life of patients, with high safety.

Key words: non-small cell lung cancer, chemotherapy, targeted drug therapy, clinical efficacy, adverse reactions

中图分类号:

R734.2

辛红梅, 包雍剑. 晚期非小细胞肺癌患者采用化学治疗联合靶向药物治疗的临床疗效[J]. 中华养生保健, 2022, 40(10): 18-20.

XIN Hong-mei, BAO Yong-jian. The Study of Efficacy of Chemotherapy Combined with Targeted Drug Therapy in Patients with Advanced Non-small Cell Lung Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(10): 18-20.

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