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中华养生保健 ›› 2025, Vol. 43 ›› Issue (7): 1-5.

• 论著 •    下一篇

18F-FDG PET-CT影像学特点对NSCLC进展的预测作用

王明月1, 姚岚2, 张娜1, 朱坤3, 高守宝4, 杨晓峰5, 白天1, 季佳6, 黄启成1,*   

  1. 1.齐齐哈尔医学院附属第三医院放射影像中心,黑龙江 齐齐哈尔,161000;
    2.齐齐哈尔医学院附属第三医院核医学科,黑龙江 齐齐哈尔,161000;
    3.齐齐哈尔医学院附属第三医院胸外一科,黑龙江 齐齐哈尔,161000;
    4.齐齐哈尔医学院附属第三医院肿瘤二科,黑龙江 齐齐哈尔,161000;
    5.齐齐哈尔医学院病理中心,黑龙江 齐齐哈尔,161000;
    6.齐齐哈尔医学院附属第三医院口腔科,黑龙江 齐齐哈尔,161000
  • 出版日期:2025-04-01 发布日期:2025-04-02
  • 通讯作者: * 黄启成,E-mail：Huangqicheng1981@163.com。
  • 作者简介:王明月（1999—）,女,汉族,籍贯：河北省沧州市,硕士研究生,医师,研究方向：放射影像学。
  • 基金资助:
    黑龙江省卫生健康委科研课题（20220909010629）

Prognostic Effect of 18F-FDG PET-CT Imaging Features on NSCLC Progression

WANG Ming-yue1, YAO Lan2, ZHANG Na1, ZHU Kun3, GAO Shou-bao4, YANG Xiao-feng5, BAI tian1, JI jia6, HUANG Qi-cheng1,*   

  1. 1. Radiological Imaging Center, the Third Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China;
    2. Department of Nuclear Medicine, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China;
    3. Department of Thoracic Surgery, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China;
    4. The Second Department of Oncology, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China;
    5. Pathology Center, Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China;
    6. Department of Stomatology, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar Heilongjiang, 161000, China
  • Online:2025-04-01 Published:2025-04-02

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摘要： 目的探究18F-脱氧葡萄糖正电子发射断层显像（18F-FDG PET-CT）影像学特点对非小细胞肺癌（NSCLC）进展（以淋巴结转移为评估标准）的预测作用。方法 回顾性分析2021年5月—2023年5月齐齐哈尔医学院附属第三医院收治的100例NSCLC患者,其中未发生淋巴结转移的患者40例,发生淋巴结转移的患者60例,所有患者均接受18F-FDG PET-CT检查。分析18F-FDG PET-CT检查分期的准确性及两组患者一般资料、影像学参数之间的差异。结果 18F-FDG PET-CT检查分期准确率为87.00%。淋巴结转移组的最大标准摄取值（SUVmax）、原发灶代谢肿瘤体积（MTV-P）、原发灶和转移灶代谢肿瘤体积（MTV-C）、原发灶糖酵解总量（TLG-P）、原发灶和转移灶糖酵解总量（TLG-C）高于淋巴结未转移组,差异有统计学意义（P<0.05）。肿瘤大小、SUVmax、MTV-P、MTV-C、TLG-P、TLG-C与NSCLC进展呈正相关,且均为NSCLC进展的危险因素,各参数联合预测NSCLC进展的曲线下面积（AUC）为0.988。结论 18F-FDG PET-CT在NSCLC进展的预测中发挥着重要作用,尤其是SUV、MTV和TLG参数对NSCLC进展的联合预测效能较好。

关键词: 18F-脱氧葡萄糖正电子发射断层显像, 影像学参数, 非小细胞肺癌, 预测效能

Abstract: Objective To investigate the predictive effect of 18F-deoxyglucose positron emission tomography (18F-FDG PET-CT) imaging features on progression of non-small cell lung cancer (NSCLC) with lymph node metastasis as the evaluation criterion. Methods A total of 100 patients with NSCLC admitted to the Third Affiliated Hospital of Qiqihar Medical College from May 2021 to May 2023 were retrospectively analyzed, including 40 patients without lymph node metastasis and 60 patients with lymph node metastasis. All patients received 18F-FDG PET-CT examination. The accuracy of 18F-FDG PET-CT staging and the differences of general data and imaging parameters between the two groups were analyzed. Results The staging accuracy of 18F-FDG PET-CT was 87.00%. The maximum standard uptake value (SUVmax), primary metabolic tumor volume (MTV-P), primary and metastatic metabolic tumor volume (MTV-C), total primary and metastatic glycolysis (TLG-P), and total primary and metastatic glycolysis (TLG-C) in lymph node metastasis group were higher than those in non-metastatic lymph node group. The difference was statistically significant (P<0.05). Tumor size, SUVmax, MTV-P, MTV-C, TLG-P and TLG-C were positively correlated with the progression of NSCLC and were all risk factors for the progression of NSCLC. The area under the curve (AUC) of the combined prediction of NSCLC progression was 0.988. Conclusion 18F-FDG PET-CT plays an important role in the prediction of NSCLC progression, especially the combined prediction of SUV, MTV and TLG parameters is good.

Key words: 18F-deoxyglucose positron emission tomography, imaging parameters, non-small cell lung cancer, predictive effectiveness

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