通痹祛湿活血汤对血虚风燥型银屑病患者症状积分及血清因子的影响

摘要/Abstract

摘要： 目的探讨通痹祛湿活血汤对血虚风燥型银屑病患者的症状积分及血清因子的影响。方法选取2021年1月—2023年6月同济大学附属东方医院胶州医院收治的94例血虚风燥型银屑病患者,随机数表法分为两组,每组47例。对照组采取常规西药治疗,观察组在对照组基础上加上通痹祛湿活血汤治疗,两组均治疗12周。比较两组症状积分、病症改善情况、血清因子、临床疗效。结果治疗12周后,观察组主症、次症总积分低于对照组（P<0.05）。治疗12周后,观察组的皮损角质层含水量高于对照组,PASI评分低于对照组,关节疼痛/肿胀个数少于对照组（P<0.05）。治疗12周后,观察组白细胞介素-6（IL-6）、C反应蛋白（CRP）、骨桥蛋白（OPN）水平低于对照组（P<0.05）。治疗12周后,观察组总有效率高于对照组（P<0.05）。结论在常规西药基础上采用通痹祛湿活血汤治疗血虚风燥型银屑病,可以促进皮损、关节疼痛等症状的恢复,减少炎性物质,提升临床效果。

关键词: 银屑病, 血虚风燥型, 通痹祛湿活血汤, 皮损情况, 治疗效果

Abstract: Objective To investigate the effects of Tongbi Qushi Huoxue Decoction and Zidan-Yinzhuo capsule on symptom scores and serum factors of patients with blood-deficiency wind-dryness psoriasis. Methods Ninety-four patients with blood deficiency and wind psoriasis admitted to our hospital from January 2021 to June 2023 were divided into two groups with 47 patients in each group. Both groups received conventional western medicine treatment, the control group was treated with purple Dan psoriasis capsule, the observation group was treated on the basis of the control group, both groups were treated for 12 weeks. Compare symptom integration, disease improvement, serum factors, and clinical efficacy between the groups. Results After 12 weeks of treatment, the total score of the main and secondary symptoms in the observation group was lower than that in the control group (P<0.05). After 12 weeks of treatment, the water content of the stratum corneum in the observation group was higher than that in the control group, while the PASI score and the number of joint pain/swelling were lower than those in the control group (P<0.05). After 12 weeks of treatment, the levels of IL-6, CRP, and OPN in the observation group were lower than those in the control group (P<0.05). After 12 weeks of treatment, the total effective rate of the observation group was higher than that of the control group (P<0.05). Conclusion On the basis of conventional western medicine, Tongbi Qushi Huoxui Decoction is used to treat blood deficiency wind-dryness psoriasis, which can promote the recovery of skin lesions, joint pain and other symptoms, reduce inflammatory substances, and improve clinical effect.

Key words: psoriasis, blood vacuity wind dryness type, Tongbi Qushi Huoxue Decoction, purple dan silver dust capsule, therapeutic effect

中图分类号:

R275.9

刘伟. 通痹祛湿活血汤对血虚风燥型银屑病患者症状积分及血清因子的影响[J]. 中华养生保健, 2024, 42(21): 23-27.

LIU Wei. Effects of Tongbi Qushi Huoxue Decoction on Symptom Scores and Serum Factors of Patients with Blood-Vacuity Wind-Dryness Psoriasis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(21): 23-27.

参考文献

[1] 李丹,孟静,韩传恩.复方氨肽素片联合卤米松乳膏治疗寻常型银屑病的临床研究[J].现代药物与临床,2022,37(6):1329-1333.
[2] 桂雨晴,唐彩红,陈镜宇,等.克立硼罗软膏调节角质形成细胞异常活化缓解小鼠银屑病作用[J].安徽医科大学学报,2023,58(5):735-741.
[3] 王英杰,姜珠倩,彭勇,等.养血宣透方联合中药药浴治疗寻常型银屑病(血燥证)临床疗效观察[J].海南医学,2021,32(19):2529-2532.
[4] 蒋宁兰,羊羡,陈邦第,等.润肤止痒洗剂联合卡泊三醇软膏治疗血虚风燥型寻常型银屑病静止期的临床研究[J].湖南中医药大学学报,2021,41(1):134-138.
[5] 文昌晖,张硕,贾敏,等.消疕汤对血热风燥型银屑病患者血清IL-8、IL-10水平的影响[J].贵州医药,2019,43(2):196-198.
[6] 周志航,王建国,丁厚鹏.活血通痹汤联合富血小板血浆治疗膝骨性关节炎54例[J].中国中医骨伤科杂志,2022,30(1):61-64.
[7] 中华医学会皮肤性病学分会,中国医师协会皮肤科医师分会,中国中西医结合学会皮肤性病专业委员会.中国银屑病生物治疗专家共识(2019)[J].中华皮肤科杂志,2019,52(12):863-871.
[8] 中华中医药学会皮肤科分会.皮肤科分会银屑病中医治疗专家共识(2017年版)[J].中国中西医结合皮肤性病学杂志,2018,17(3):273-277.
[9] 郑筱萸. 中药新药临床研究指导原则:试行[J].北京:中国医药科技出版社, 2002:299-302.
[10] 中国医师协会皮肤科医师分会,中华医学会皮肤性病学分会,空军军医大学西京医院,等.中国银屑病患者饮食管理指南(2023)[J].中华皮肤科杂志,2023,56(5):389-401.
[11] 银屑病防治研究教育专项基金委员会.生物反馈疗法调治银屑病专家共识(2019)[J].中国临床医生杂志,2019,47(9):1033-1035.
[12] 王乐,姜俊杰,战杨,等.通痹祛湿活血汤联合微针灸治疗血虚风燥型银屑病对中医证候、症状、炎症因子的影响[J].中华中医药学刊,2023,41(1):42-45.
[13] 李楚,段德鉴,李滨燕,等.养血解毒祛湿汤治疗寻常型银屑病血燥夹湿证患者的临床疗效观察[J].广州中医药大学学报,2022,39(10):2289-2295.
[14] 郭兰天,于军.水牛角蜂房汤治疗寻常型银屑病血热证验案[J].亚太传统医药,2021,17(4):94-96.
[15] 黄小珊,蓝凰齐,唐汉庆,等.木姜子和忍冬藤配伍醇提物对哮喘细胞外信号调节激酶1/2-白细胞介素-17通路及细胞增殖凋亡的影响[J].中国临床药理学杂志,2020,36(7):775-778.
[16] 佟一鑫,柏强.基于网络药理学和分子对接技术探究夜交藤治疗失眠的作用机制[J].中医临床研究,2021,13(26):1-5.