关键词: 肺楔形切除术, 解剖性肺叶切除术, 早期肺癌, 炎性应激, 并发症, 肺功能

Abstract: Objective To investigate the effects of pulmonary wedge resection and anatomic lobectomy on postoperative rehabilitation of patients with early lung cancer. Methods A total of 84 patients with early lung cancer admitted by People's Hospital of Dali Bai Autonomous Prefecture from January 2019 to January 2022 were selected as research objects for a parallel retrospective study. Subjects were divided into two groups according to different operation methods (42 cases in each group). Patients in the control group and the study group underwent thoracoscopic anatomic lobectomy and pulmonary wedge resection, operation-related indexes, inflammatory stress, complication rate, postoperative pulmonary function indexes and recurrence rate, metastasis rate, mortality rate, and cumulative survival rate after 1-year follow-up after surgery were compared between the two groups. Results The pain duration, thoracic drainage time, first time out of bed and hospital stay in the study group were shorter than those in the control group,with significant differences between the groups (P<0.05). The level of interleukin-6 (IL-6), interleukin-1β ( IL-1β), hypersensitive C-reactive protein (hs-CRP) and tumor necrosis factor- α(TNF- α) in two groups of patients after surgery were significantly higher than before surgery, but lower in the study group compared to the control group (P<0.05). The incidence of complications in the study group was lower than that in the control group, accounting for 9.52% and 26.19%, respectively, and the difference between groups was significant (P<0.05). After surgery, the first second forced expiratory volume (FEV₁), forced vital capacity (FVC), peak expiratory flow (PEF), maximum ventilation volume (MVV), and vital capacity (VC) levels in both groups of patients were significantly reduced compared to before surgery, but compared to the control group, the study group had a higher level (P<0.05).There was no significant difference in recurrence rate, metastasis rate, mortality rate and cumulative survival rate between the study group and the control group during follow-up (P>0.05). Conclusion In the treatment of early lung cancer patients, compared with anatomical lobectomy, pulmonary wedge resection is more beneficial to reduce the pain and inflammatory stress of the body, has less impact on lung function, fewer postoperative complications, and shorter recovery time, which can promote the postoperative rehabilitation of patients.

Key words: pulmonary wedge-shaped resection, anatomic pulmonary lobectomy, early lung cancer, inflammatory stress, complications, lung function