SOD、GSH-Px、MDA、MPO与脑血管病后癫痫发生的预测价值

摘要/Abstract

摘要： 目的探讨超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）、髓过氧化物酶（MPO）与脑血管病后癫痫发生的预测价值。方法选取2018年6月—2023年6月贺兰县人民医院收治的180例脑血管疾病患者为研究对象,依照脑血管疾病发生之后是否出现癫痫进行分组,分为癫痫组（n=28）和非癫痫组（n=152）,另选取同期来贺兰县人民医院体检的30名健康志愿者作为对照组。对比三组受检者SOD、GSH-Px、MDA、MPO表达水平,应用Logistic回归分析法分析SOD、GSH-Px、MDA、MPO对脑血管病后癫痫发生的预测价值。随后将28例脑血管病后癫痫患者依照发作类型分为两个亚组,即部分性发作组（n=15）和全身强直痉挛发作组（n=13）,对比两组患者SOD、GSH-Px、MDA、MPO表达水平,并采用Spearman相关分析方法分析SOD、GSH-Px、MDA、MPO与脑血管病后癫痫严重程度的相关性。结果癫痫组SOD、GSH-Px水平明显低于非癫痫组和对照组,MDA、MPO水平明显高于非癫痫组和对照组,差异有统计学意义（P<0.05）;Logistic回归分析结果显示：SOD、GSH-Px降低和MDA、MPO升高为脑血管病后癫痫发作的独立影响因素（P<0.05）;全身强直痉挛发作组患者SOD、GSH-Px水平低于部分性发作组,MDA、MPO水平高于部分性发作组,差异有统计学意义（P<0.05）;Spearman相关分析结果显示：SOD、GSH-Px与脑血管病后癫痫严重程度呈负相关,MDA、MPO与脑血管病后癫痫严重程度呈正相关（P<0.05）。结论通过观察血清SOD、GSH-Px、MDA、MPO水平可预测脑血管病后癫痫的发生,且SOD、GSH-Px水平越低,MDA、MPO水平越高,患者癫痫发作情况越严重,因此临床上针对此类脑血管病患者需及时采取相关措施进行干预,预防癫痫发生,并减轻脑血管病后癫痫发作的严重程度。

关键词: 脑血管病, 癫痫, 超氧化物歧化酶, 谷胱甘肽过氧化物酶, 丙二醛, 髓过氧化物酶

Abstract: Objective To explore the predictive value of Superoxide dismutase (SOD), Glutathione peroxidase (GSH Px), Malondialdehyde (MDA), Myeloperoxidase (MPO) and epilepsy after cerebrovascular disease. Methods 180 patients with Cerebrovascular disease admitted to Helan County People's Hospital from June 2018 to June 2023 were selected as the study subjects. They were divided into epilepsy group (n=28) and non epilepsy group (n=152) according to whether epilepsy occurred after the occurrence of cerebrovascular disease. In addition, 30 healthy volunteers who came to Helan County People's Hospital for physical examination at the same time were selected as the control group. Compare the expression levels of SOD, GSH-Px, MDA, and MPO among three groups of subjects, and use logistic regression analysis to analyze the predictive value of SOD, GSH-Px, MDA, and MPO for the occurrence of epilepsy after cerebrovascular disease. Subsequently, 28 patients with epilepsy after cerebrovascular disease were divided into two subgroups based on the type of seizure, namely the partial seizure group (n=15) and the systemic tetanic spasm group (n=13). And Spearman correlation analysis was used to analyze the correlation between SOD, GSH-Px, MDA and MPO and seizure severity after cerebrovascular disease. Result The levels of SOD and GSH-Px in the epilepsy group were significantly lower than those in the non epilepsy group and control group, while the levels of MDA and MPO were significantly higher than those in the non epilepsy group and control group (P<0.05); Logistic regression analysis showed that the decrease of SOD, GSH Px and the increase of MDA and MPO were independent factors influencing Seizure after cerebrovascular disease (P<0.05); The levels of SOD and GSH-Px in patients with generalized tonic spasm were lower than those in the partial seizure group, while the levels of MDA and MPO were higher than those in the partial seizure group (P<0.05); The Spearman correlation analysis results showed that SOD, GSH-Px were negatively correlated with the severity of epilepsy after cerebrovascular disease, while MDA, MPO were positively correlated with the severity of epilepsy after cerebrovascular disease (P<0.05). Conclusion The observation of serum SOD, GSH Px, MDA, MPO levels can predict the occurrence of epilepsy after cerebrovascular disease, and the lower the level of SOD, GSH Px and the higher the level of MDA, MPO, the more serious the seizure in patients with such cerebrovascular disease. Therefore, in clinical practice, relevant measures should be taken in time to prevent epilepsy and reduce the severity of seizure after cerebrovascular disease.

Key words: cerebrovascular disease, epilepsy, superoxide dismutase, glutathione peroxidase, malondialdehyde, myeloperoxidase

中图分类号:

R743

闫丽, 潘兰兰, 顾淑娥. SOD、GSH-Px、MDA、MPO与脑血管病后癫痫发生的预测价值[J]. 中华养生保健, 2024, 42(14): 89-92.

YAN Li, PAN Lan-lan, GU Shue. The predictive value of SOD, GSH-Px, MDA, MPO in the occurrence of epilepsy after cerebrovascular disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(14): 89-92.

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