25-OH-D、ANCA在系统性红斑狼疮患者中的表达及与疾病活动程度的关系分析

摘要/Abstract

摘要： 目的分析血清25-羟基维生素D（25-OH-D）、抗中性粒细胞胞质抗体（ANCA）在系统性红斑狼疮（SLE）患者中的表达及与疾病活动程度的关系。方法选择2022年4月—2023年4月内蒙古自治区人民医院收治的62例SLE患者作为观察组,纳入同时期60名体检健康志愿者为对照组,检测组间25-OH-D、ANCA水平,比较观察组内活动期与非活动期患者组间25-OH-D、ANCA水平,同时,采用Logistic多因素分析SLE疾病活动程度的影响因素。结果观察组25-OH-D水平低于对照组,ANCA水平高于对照组,差异有统计学意义（P<0.05）;活动期SLE患者25-OH-D水平低于非活动期SLE患者,ANCA水平高于非活动期SLE患者,差异有统计学意义（P<0.05）;以25-OH-D、ANCA表达为自变量、连续变量,将SLE活动程度作为因变量（轻度=0,重度=1）,进行Logistic回归分析。结果显示,25-OH-D低表达与ANCA高表达为SLE活动程度的影响因素（P<0.05）;以SLE疾病为自变量,以25-OH-D、ANCA及两项联合水平为因变量,预测模型最佳临界值为0.089,曲线下面积（AUC）为0.702（0.646~0.758）、0.713（0.651~0.779）、0.879（0.782~0.991）。结论 25-OH-D在SLE患者中呈低表达水平,ANCA呈现高表达水平,25-OH-D、ANCA是SLE疾病活动期发生的主要影响因素,在临床SLE疾病诊断及疾病活动程度预测中具有较高的应用价值,建议临床使用。

关键词: 25-OH-D, ANCA, 系统性红斑狼疮, 疾病活动程度

Abstract: Objective To analyze the expression of serum 25-hydroxyvitamin D (25-hydroxyvitamin D, 25-OH-D) and antineutrophilic cytosolic antibody (Anti-neutrophil cytosolic antibodies, ANCA) in patients with systemic lupus erythematosus (systemic lupus erythematosus, SLE). Methods In the study, 62 patients with SLE were admitted to the hospital from April 2022 to April 2023 were the study observers, and 60 healthy volunteers in the same period were included as the control group to detect 25-OH-D and ANCA between the groups, and compare 25-OH-D and ANCA between the active patients in the observation group. Meanwhile, the factors of SLE disease activity were analyzed by Logistic. Results 25-OH-D was lower than the control group, and the difference was statistically significant (P<0.05); active SLE patients 25-OH-D lower than inactive SLE, ANCA higher than inactive SLE patients, and the difference was statistically significant (P<0.05); 25-OH-D expression and ANCA as independent variable, continuous variable; SLE activity degree as dependent variable (mild=0, severe=1), Logistic regression analysis. The results showed that 25-OH-D and ANCA influenced the degree of SLE activity (P<0.05); with SLE disease as the independent variable, 25-OH-D, ANCA and the joint levels, the optimal cut-off value was 0.089 (area under curve, AUC) was 0.702 (0.646~0.758), 0.713 (0.651~0.779), 0.879 (0.782~0.991). Conclusion 25-OH-D has low expression level in SLE patients, and ANCA shows high expression level. 25-OH-D and ANCA are the main influencing factors of SLE disease activity period, with high application value in clinical SLE disease diagnosis and disease activity degree prediction, so clinical use is recommended.

Key words: 25-OH-D, ANCA, systemic lupus erythematosus, degree of disease activity

中图分类号:

R593.241

张志静, 李晖云. 25-OH-D、ANCA在系统性红斑狼疮患者中的表达及与疾病活动程度的关系分析[J]. 中华养生保健, 2024, 42(4): 53-56.

ZHANG Zhi-jing, LI Hui-yun. Expression of 25-OH-D, ANCA in Patients with Systemic Lupus Erythematosus and Its Relationship with the Degree of Disease Activity[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(4): 53-56.

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