空气灌肠术治疗急性肠套叠疗效及HMGB1不同监测意义

摘要/Abstract

摘要： 目的探讨空气灌肠术治疗急性肠套叠患者的临床效果,监测急性肠套叠患者不同时期体内高迁移率族蛋白1（HMGB1）表达水平及其临床意义。方法选取新疆生产建设兵团第十三师红星医院2017年1月—2022年12月收治的68例急性肠套叠患儿作为本研究的观察组,入组患儿均给予简易空气灌肠术进行治疗,选择同期在新疆生产建设兵团第十三师红星医院进行健康检查的68名健康儿童作为对照组,观察空气灌肠术治疗急性肠套叠的临床效果以及HMGB1监测的临床意义。结果观察组68例患儿中,66例复位成功,成功率达97.06%;复位成功后留院观察24 h以上,其中有53例（80.30%）患儿出现轻度腹泻,经治疗后全部好转,未见其他不良反应,2例复位失败后转手术治疗;治疗前后,观察组患儿的HMGB1、白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均明显高于对照组,差异有统计学意义（P<0.05）;治疗后有7例患儿复发,复发组患儿的HMGB1水平明显高于未复发组,差异有统计学意义（P<0.05）。结论空气灌肠术治疗急性肠套叠临床效果显著,患儿复发率较低,HMGB1的水平和TNF-α与IL-6水平明显降低,在临床上对于急性肠套叠的诊断具有一定的诊断意义,值得关注。

关键词: 急性肠套叠, 空气灌肠术, 高迁移率族蛋白1, 监测

Abstract: Objective To explore the clinical effect of air enema in patients with acute intussusception, and to monitor the expression level of high mobility group protein 1 (HMGB 1) in different periods. Methods The Xinjiang production and construction corps 13 division red star hospital since January 2017 to December 2022 admitted 68 cases of acute intussusception children as the observation of the study, enrolled children are given simple air enema treatment, choose the same period in the Xinjiang production and construction corps 13 division red star hospital health examination 68 cases of healthy children as a control group, observe the clinical effect of air enema treatment of acute intussusception and the clinical significance of HMGB 1 monitoring. Results In 68 children of the observation group, 66 cases were successfully reset, with a success rate of 97.06%. After successful reduction, 53 children (80.30%) had mild diarrhea, all of them improved after treatment, and no other adverse reactions were found. 2 patients were transferred to surgery after failed reduction. HMGB1, IL-6, TNF-α in the observation group before and after treatment. The levels were significantly higher than those of the healthy control group, but decreased significantly after treatment (P<0.05). After treatment, 7 children recurred, and the level of HMGB1 in the recurred children was significantly higher than that in the non-recurred group, with a statistically significant difference between the groups (P<0.05). Conclusion The clinical effect of acute intussusception is significant, the recurrence rate of children is low, and the level of HMGB 1 and TNF- αand IL-6 are significantly reduced, which has certain diagnostic significance for the diagnosis of acute intussusception and deserves attention.

Key words: acute intussusception, air enema, HMGB1, monitor

中图分类号:

R459.7

苏振磊. 空气灌肠术治疗急性肠套叠疗效及HMGB1不同监测意义[J]. 中华养生保健, 2023, 41(15): 19-22.

SU Zhen-lei. Effect of Air Enema on Acute Intussusception and Different Monitoring Significance of HMGB1[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(15): 19-22.

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