2型糖尿病患者血清S100A12、sRAGE与微血管并发症的关系研究

摘要/Abstract

摘要： 目的探讨与研究2型糖尿病患者血清钙结合蛋白（S100A12）、晚期糖基化终末产物受体（RAGE）与微血管并发症的关系。方法回顾性选择2021年2月~2021年12月在哈尔滨市第四医院诊治的96例2型糖尿病患者作为研究对象,判定微血管并发症发生情况。检测所有患者血小板四项参数,血清S100A12、sRAGE含量,分析2型糖尿病患者血清S100A12、sRAGE与微血管并发症的相关性及影响因素。结果在96例患者中,发生糖尿病微血管并发症36例（合并组）,占37.50%,其中糖尿病周围神经病变20例,糖尿病肾病10例,糖尿病视网膜病变6例。合并组的血小板分布宽度（PDW）、平均血小板体积（MPV）明显高于对照组,差异有统计学意义（P<0.05）,合并组血小板计数（PLT）、血小板压积（PCT）明显低于对照组,差异有统计学意义（P<0.05）。合并组的血清S100A12、sRAGE含量明显高于对照组,差异有统计学意义（P<0.05）。在96例患者中,Pearson分析显示血清S100A12、sRAGE含量与微血管并发症的发生存在正相关性（P<0.05）。多元逐步Logistic回归分析显示,血清S100A12、sRAGE含量为导致微血管并发症发生的重要危险因素（P<0.05）。结论 2型糖尿病患者多伴随有微血管并发症,以糖尿病周围神经病变多见,糖尿病微血管并发症患者的血清S100A12、sRAGE含量降低,2型糖尿病患者血清S100A12、sRAGE与微血管并发症的发生存在相关性。

关键词: 2型糖尿病, 微血管并发症, 糖尿病周围神经病变, 晚期糖基化终末产物受体, S100A12, 相关性

Abstract: Objective To explore and study the relationship between serum S100A12, receptor for advanced glycation end-products (RAGE) and microvascular complications in patients with type 2 diabetes mellitus. Methods A total of 96 patients with type 2 diabetes who were diagnosed and treated in Harbin Fourth Hospital from February 2021 to December 2021 were retrospectively selected as the research subjects to determine the occurrence of microvascular complications.The four parameters of platelet, serum S100A12 and sRAGE contents in all patients were detected, and the correlation and influencing factors of serum S100A12 and sRAGE in type 2 diabetes patients with microvascular complications were analyzed. Results There were 36 cases of diabetic microvascular complications (combined group) occurred in the 96 cases that accounted for 37.50%, included 20 cases of diabetic peripheral neuropathy, 10 cases of diabetic nephropathy, and 6 cases of diabetic retinopathy. The platelet distribution width and mean platelet volume in the combined group were significantly higher than those in the control group, the difference is statistically significant (P<0.05), and the platelet count and platelet volume were significantly lower than those in the control group, the difference is statistically significant (P<0.05). The serum levels of S100A12 and sRAGE in the combined group were significantly higher than those in the control group, the difference is statistically significant (P<0.05). In the 96 patients, Pearson analysis showed that serum S100A12 and sRAGE levels were positively correlated with the occurrence of microvascular complications (P<0.05). Multivariate stepwise Logistic regression analysis showed that serum S100A12 and sRAGE levels were important risk factors for microvascular complications (P<0.05). Conclusion Type 2 diabetes patients are often accompanied by microvascular complications, and diabetic peripheral neuropathy is more common. The serum levels of S100A12 and sRAGE in patients with diabetes microvascular complications are decreased. There is a correlation between serum S100A12 and sRAGE in type 2 diabetes patients and the occurrence of microvascular complications.

Key words: type 2 diabetes, microvascular complications, diabetic peripheral neuropathy, receptor for advanced glycation end products, S100A12, correlation

中图分类号:

R446.6

马琳娜, 李媛红. 2型糖尿病患者血清S100A12、sRAGE与微血管并发症的关系研究[J]. 中华养生保健, 2023, 41(2): 1-4.

MA Lin-na, LI Yuan-hong. The Relationship between Serum S100A12, sRAGE and Microvascular Complications in Patients with Type 2 Diabetes Mellitus[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(2): 1-4.

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