甘草酸二铵胶囊治疗老年肝功能不全的临床效果

摘要/Abstract

摘要： 目的探讨老年肝功能不全患者采用甘草酸二铵胶囊治疗的临床效果。方法选取2020年3月—2023年3月滨州市滨城区人民医院收治的80例老年肝功能不全患者作为研究对象,按照随机数表法分成研究组和对照组,每组40例。对照组给予葡醛内酯片治疗,研究组给予甘草酸二铵胶囊治疗,比较两组临床疗效、肝功能、氧化应激指标、不良反应。结果研究组的治疗总有效率高于对照组,差异有统计学意义（P<0.05）。治疗后,两组丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、总胆红素（TBil）、γ-谷氨酰转肽酶（γ-GT）水平均下降,且研究组较对照组更低,差异有统计学意义（P<0.05）。治疗后,两组超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）水平升高,丙二醛（MDA）水平下降,且研究组SOD、GSH水平较对照组更高,MDA水平较对照组更低,差异有统计学意义（P<0.05）。两组不良反应发生率比较,差异无统计学意义（P>0.05）。结论甘草酸二铵胶囊应用于老年肝功能不全治疗中,能够提高临床疗效,改善患者肝功能,缓解机体氧化应激反应,不会导致不良反应增加。

关键词: 甘草酸二铵胶囊, 老年肝功能不全, 临床疗效, 安全性

Abstract: Objective To explore the clinical efficacy of using diammonium glycyrrhizinate capsules for the treatment of elderly patients with liver dysfunction. Methods A total of 80 elderly patients with liver dysfunction from March 2020 to March 2023 who were admitted in Binzhou Bincheng District People's Hospital were selected, and randomly divided into the study group and the control group, each group consisted of 40 cases. The control group was treated with glucuronic acid tablets, and the study group was treated with diammonium glycyrrhizinate capsules.The clinical efficacy,liver function, oxidative stress indicators,and adverse reactions in both groups were compared. Results The total effective rate of treatment in the study group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment,the alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), and gamma glutamyl transpeptidase (γ-GT) levels in both groups were decreased(P<0.05), and in comparison of the control group, the study group was lower,and the study group was lower than the control group, with a statistically significant difference(P<0.05). After treatment,the superoxide dismutase (SOD) and glutathione (GSH) levels in both groups were increased, the malondialdehyde (MDA) levels were decreased The levels of SOD and GSH in the study group were higher than those in the control group, and the level of MDA was lower, with statistical significance (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of diammonium glycyrrhetinic acid capsules in the treatment of elderly liver dysfunction can improve clinical efficacy,improve patient liver function, alleviate oxidative stress reactions,and not lead to an increase in adverse reactions.

Key words: diammonium glycyrrhetinic acid capsules, elderly liver dysfunction, clinical efficacy, safety

中图分类号:

R975

姚再荣, 白利军. 甘草酸二铵胶囊治疗老年肝功能不全的临床效果[J]. 中华养生保健, 2025, 43(10): 60-64.

YAO Zai-rong, BAI Li-jun. Clinical Efficacy of Diammonium Glycyrrhizinate Capsules in the Treatment of Elderly Liver Dysfunction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(10): 60-64.

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